חדשות המחקר
Hadas Shasha-Lavsky, Karl Skorecki, Kamal Hassan, Etty Kruzel, Khaled Khazim, Ronit Geron, Irit Weisman, Anaam Hanut, Farid Nakhoul, Gidi Rechavi: Genetic Markers Among the Israeli Druze Minority Population With End-Stage Kidney Disease (Am J Kidney Dis .
Genetic etiologies have been identified among approximately 10% of adults with chronic kidney disease. However, data are lacking regarding the prevalence of monogenic etiologies especially among members of minority groups. The objective of this study was to characterize the genetic markers among members of an Israeli minority group with end-stage kidney disease (ESKD).
Ethnic disparities in presentation but not outcome in multiple myeloma patients: a multicenter retrospective study in Northern Israel (Leuk Lymphoma . )
Several studies showed ethnic disparities in multiple myeloma (MM) incidence and prognosis. In order to compare prognosis and overall survival between different ethnic groups, a multicenter retrospective study was conducted in Northern Israel.
(Najib Dally, Myriam Baranes, Luiza Akria, Marat Kashlikov, Khalil Tarabia, Adi Sharabi-Nov, Celia Suriu, Andrei Braester)
Tawfik Khoury, Wisam Sbeit: Safety and Efficacy of Endoscopic Ultrasound-guided Radiofrequency Ablation for Pancreatic Neuroendocrine Neoplasms: Systematic Review and Meta-analysis (Dig Endosc . )
Endoscopic ultrasound guided radiofrequency ablation (EUS-RFA) has been constantly increasing, particularly in the treatment of pancreatic neuroendocrine neoplasms (pNENs). While emerging data in this field are accumulating, we aimed to assess the pooled efficacy and safety of EUS-RFA for pNENs.
Wisam Sbeit, Nidaa Abu Hanna, Livoff Alejandro, Tawfik Khoury: The yield of cytology and histology obtained by endoscopic ultrasound-guided fine needle aspiration and biopsy needles in the diagnosis of pancreatic adenocarcinoma (Cytopathology .)
Endoscopic ultrasound-guided fine needle aspiration and biopsy (EUS-FNA, -FNB) are the mainstay for tissue diagnosis of pancreatic lesions. Traditionally, FNA was performed for obtaining cytology and also histology if available from the puncture. Since their advent, however, FNB needles have been intended mainly to obtain core biopsies for histological specimens. Aims: We aimed to assess the yield of cytology obtained via both FNA and FNB needles.
Eric S Shinwell: Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial (JAMA .)
The long-term effects of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome remain to be definitively clarified. Objective: To examine the effect of MIST on death or neurodevelopmental disability (NDD) at 2 years' corrected age.
Cohen Yuval, Chassid Otzem: Evaluating the Effect of a Myopia Control Spectacle Lens Among Children in Israel: 12-Month Results (Am J Ophthalmol .)
Investigates the effectiveness of a novel spectacle lens designed to slow the progression of myopia in children.
Firas Sabbah, Mohammad E Naffaa: Outcomes in progressive systemic sclerosis treated with autologous hematopoietic stem cell transplantation compared with combination therapy (Rheumatology (Oxford) . )
Autologous hematopoietic stem cell transplantation (AHSCT) has been shown to improve long-term survival for early diffuse progressive systemic sclerosis (SSc) compared with cyclophosphamide. Cyclophosphamide, however, does not provide a long-term benefit in SSc. The combination of mycophenolate mofetil (MMF) and rituximab is a potent alternative regimen. We aimed to retrospectively compare the outcomes of SSc patients who underwent AHSCT to patients who met the eligibility criteria for AHSCT but received upfront combination therapy with MMF and rituximab.
Naim Shehadeh: Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review (Adv Ther .)
Type 2 diabetes (T2D) in youth is a global health concern characterized by an increasing incidence and prevalence, especially among disadvantaged socioeconomic subgroups. Moreover, youth-onset T2D is more aggressive and causes earlier, more severe long-term cardio-renal complications compared with T2D in adults. The therapeutic options available are limited and often inadequate, partially due to the numerous challenges in implementing clinical trials for this vulnerable patient population. Over the last few years, a significant effort has been made to develop new effective drugs for children and adolescents with T2D. Specifically, a number of studies are currently generating new data to address the urgent unmet medical need for optimal management of this disease. This review describes the central features of youth-onset T2D and summarizes the available treatments and ongoing studies in pediatric patients.
Boris Fichtman, Amnon Harel: A single filament biomechanical study of the enteropathogenic Escherichia coli Type III secretion system reveals a high elastic aspect ratio (Nanoscale . )
Type III secretion systems (T3SSs) are syringe-like protein complexes used by some of the most harmful bacterial pathogens to infect host cells. While the T3SS filament, a long hollow conduit that bridges between bacteria and host cells, has been characterized structurally, very little is known about its physical properties. These filaments should endure shear and normal stresses imposed by the viscous mucosal flow during infection within the intestinal tract. We used atomic force microscopy (AFM) to probe the longitudinal and radial mechanical response of individual T3SS filaments by pulling on filaments extending directly from bacterial surfaces and later pressing into filaments that were detached from the bacteria. The measured longitudinal elastic moduli were higher by about two orders of magnitude than the radial elastic moduli. These proportions are commensurate with the role of the T3SS filament, which requires horizontal flexibility while maintaining its structural integrity to withstand intense stresses during infection.
Elon Glassberg: Low-titer group O whole blood in military ground ambulances: Lessons from the Israel Defense Forces initial experience (Transfus Med . )
Cold-stored low-titer group O whole blood (LTOWB) has become increasingly utilised in both prehospital and in-hospital settings for resuscitation of traumatic haemorrhage. However, implementing the use of LTOWB to ground medical teams has been limited due to logistic challenges.
Methods: In 2022, the Israel Defense Forces (IDF) started using LTOWB in ambulances for the first time in Israel. This report details the initial experience of this rollout and presents a case-series of the first patients treated with LTOWB.
Shelley Cohn: Perioperative Morbidity and Long-term Outcomes of Bariatric Surgery in Patients with Severe Obesity (Isr Med Assoc J . )
Long-term outcome data for bariatric surgery in patients with severe obesity (SO) (body mass index [BMI] 50 kg/m2) are scarce. Objectives: To compare perioperative morbidity and long-term outcomes between patients with SO and non-SO (NSO).
Maya Frank Wolf, Ronen Sloma, Luiza Akria, Michal Carmiel Haggai, Lior Lowenstein: Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature (Taiwan J Obstet Gynecol . )
Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy. Acute cholestatic liver injury has been reported to occur with azathioprine. We aimed to examine azathioprine related cholestasis effect on pregnancy complications and outcome.