Recent Publications
Yaseen Awad-Igbaria, Aviv Ben-Menashe, Reem Sakas, Tom Fishboom, Jean Francois-Soustiel, Eilam Palzur: Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain (Brain .)
Neuropathic pain remains one of the leading causes of global disability. The mechanism of neuropathic pain development and maintenance involves mitochondrial dysfunction induced-neuronal apoptosis of peripheral and central nociceptive pathways. The TRPV1 is a non-selective cation channel, which has a high Ca2+ permeability, playing an essential role in neuronal apoptosis in the spinal cord following peripheral nerve injury. However, the mechanism of how TRPV1 activation in the spinal cord induces mitochondrial dysfunction-mediate neuronal apoptosis, resulting in allodynia is unknown.
Mary Rudolf: The impact of trauma-informed training on pediatricians' perceived-competence in treating war-affected children: a pilot study (BMC Med Educ .)
War and collective trauma significantly affect children's physical and mental well-being. Pediatricians, as frontline healthcare providers, play a critical role in mitigating these impacts. However, many lack the training necessary to effectively address the complex needs of children affected by war. This study assesses the state of pediatricians' training, knowledge, and perceived-competence during the first weeks of the Israeli-Hamas 2023-24 war, and evaluates the effect of a trauma-informed training program on pediatricians' knowledge and perceived-competence in treating children affected by war.
Nadra Nasser Samra: The long-term associations of childhood parental loss with attachment, creativity, and epigenetic regulation (Sci Rep . )
The loss of a parent during childhood is a profound event with enduring impacts on psychological and emotional development. This study investigates the long-term effects of childhood parental loss on attachment patterns and openness to experience, with a focus on the epigenetic modulation of the oxytocin and dopamine systems.
Rawi Hazzan: Ultrasound Shear Wave Elastography and Shear Wave Dispersion: Correlation with Histopathological Changes in Autoimmune Hepatitis Patients (Ultrasound Med Biol .)
Objective: To evaluate the correlation between liver viscosity, as measured by shear wave dispersion (SWD), and fibrosis and inflammation in patients with autoimmune hepatitis (AIH). Additionally, to assess its potential as a non-invasive biomarker for hepatic fibrosis compared to shear wave elastography (SWE).
Tawfik Khoury: Safety and efficacy of endoscopic ultrasound-guided pelvic abscess drainage with lumen-apposing metal stents for complicated acute diverticulitis (Gastrointest Endosc . )
Endoscopic ultrasound-guided pelvic abscess drainage (EUS-PAD) with lumen-apposing metal stents (LAMS) is an alternative approach for post-surgical and inflammatory pelvic collections. We assess the safety and efficacy of EUS-PAD with LAMS in a large population of complicated acute diverticulitis (AD).
Soha Zgairy, Elad Rubin, Carmel Even, Sondra Turjeman, Omry Koren: Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota (NPJ Biofilms Microbiomes .)
We developed a prediction model for postprandial glycemic response (PPGR) in pregnant women, including those with diet-treated gestational diabetes mellitus (GDM) and healthy women, and explored the role of gut microbiota in improving prediction accuracy.
Michael Edelstein: Health system barriers to HPV-vaccination in adolescent females with a Moroccan or Turkish migration background in the Netherlands: A qualitative study (Vaccine .)
In the Netherlands HPV-vaccination uptake is low among females with a Moroccan or Turkish migration background. The aim of this study was to identify health system barriers to HPV-vaccine uptake among these females.
Hana Gelman: A retrospective cohort study of laparoscopic enhanced view totally extra-peritoneal Rives-Stoppa (eTEP-RS) repair of incisional ventral hernias in patients with morbid obesity Surg Endosc . )
Incisional hernia (IH) repair in morbidly obese (MO) patients poses significant challenges due to higher risks of complications and recurrence. Traditional open repairs are linked to increased morbidity, driving interest in minimally invasive techniques. The enhanced view totally extra-peritoneal Rives-Stoppa (eTEP-RS) technique shows promise as a laparoscopic method for IH repair, but data on its efficacy and safety in MO patients are limited. This study aims to evaluate the efficacy, safety, and feasibility of the eTEP-RS approach specifically for IH repair in this high-risk population.
Dor Ezon, Hagay Shwartz, Sagi Gleitman, Zeev Israeli, Edo Y Birati: Prognosis of Out-of-Hospital Cardiac Arrest in Underserved Rural Area (Clin Cardiol .)
Epidemiological data are lacking on patients in the rural areas who are being admitted after out-of-hospital cardiac arrest (OHCA). We report here the first descriptive analysis study of patients who were hospitalized and treated after OHCA at an academic medical center in the Lower Galilee which located in the north part of Israel.
Paul Kuodi: Prevalence and risk factors of under-five mortality due to severe acute malnutrition in Africa: a systematic review and meta-analysis (Syst Rev . )
Despite a global drop of under-five mortality by 59% between 1990 and 2019, it remains high in Low- and Middle- income Countries (LMICs)with a preponderance in Sub-Saharan Africa (SSA), Southern and Central Asia. Besides preterm and intrapartum complications, undernutrition contributes 45% of the deaths in these developing regions. In Africa, under-five mortality due to severe acute malnutrition (SAM) has stagnated at 10-40%, higher than WHO targets and the SDGs projections.
Yara Alkeesh, Inbar Ben-Shachar, Naama Marcus: Long-term Outcomes of Laparoscopic Sacrohysteropexy with SERATEX® SlimSling® Mesh: A Retrospective Case Series (Int Urogynecol J . )
Pelvic organ prolapse (POP) surgery has evolved toward minimally invasive techniques. Laparoscopic sacrohysteropexy (LSHP) is associated with reduced morbidity and lower mesh exposure risks. This study evaluates the long-term outcomes of LSHP using the SERATEX® SlimSling® mesh for isolated uterine prolapse.
Chava Kurtz, Sivan Spitzer: Patient Performance of Care Tasks During Acute Hospitalisation: A Scoping Review (J Clin Nurs . )
Patient self-care is established as improving outcomes, yet acute care in hospitals is provided such that patients tend to be passive recipients of care. Little is known about the extent and type of patient participation in treatment care tasks in acute hospital settings. Aims: To map and synthesise available literature on self-performance of care tasks in acute hospital settings.
Yarden Machlouf, Barak Levit, Alaa Awad, Adva Rom, Ory Wiesel: The differences in injury patterns and outcomes of thoracic trauma between rural and urban level two trauma centers in a single country (Eur J Trauma Emerg Surg .)
Equal level trauma centers in the same country might have significant differences regarding their demographics and types of trauma. Understanding geographic variations in injury patterns are essential for optimal care. Here we describe the differences in injury patterns and associated outcomes of thoracic trauma patients between rural and urban level-II trauma centers in a single country.
