Recent Publications
Inshirah Sgayer, Marwan Odeh, Maya Frank Wolf, Ala Aiob , Lior Lowenstein: The impact on pregnancy outcomes of late-onset gestational diabetes mellitus diagnosed during the third trimester: A systematic review and meta-analysis (Int J Gynaecol Obstet .)
Evidence is inconsistent regarding the impact of late gestational diabetes mellitus (GDM) on perinatal outcomes. Objectives: To evaluate associations of GDM diagnosed in the third trimester (late GDM) with adverse obstetric and neonatal outcomes.
Yaseen Awad-Igbaria, Saher Abu-Atta, Yara Nakhleh-Francis, Lior Lowenstein, Jacob Bornstein, Eilam Palzur:Exploring venlafaxine effects on chronic vulvar pain: Changes in mood and pain regulation networks (Neuropharmacology .)
The etiology of idiopathic pain conditions, such as Provoked vulvodynia (PV), is multifactorial. The efficiency of venlafaxine, serotonin-noradrenaline reuptake inhibitor (SNRIs) in modulating vulvar pain led to the hypothesis that PV might involve central mechanisms. Here, we investigate whether vulvar pain is associated with gene-expression changes in mood, stress and pain systems, including amygdala (Amg), medial prefrontal cortex (mPFC), and periaqueductal gray matter (PAG).
Detection and dissection of sentinel nodes in endometrial endometrioid cancer with indocyanine green using PinPoint laparoscopy: Analysis of the learning curve (Eur J Obstet Gynecol Reprod Biol . )
Early-stage endometrial endometrioid adenocarcinoma is managed through laparoscopic total hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Detection of positive nodes is rare, and lymphadenectomy may involve complications. Pelvic sentinel lymph node dissection can prevent complete dissection. Herein, we evaluated the learning curve of sentinel lymph node dissection using indocyanine green.
(Avishalom Sharon, Ala Aiob, Mohammad Kais, Liat Apel-Sarid, Renee Tendler, Grigory Dourleshter, Jacob Bornstein)
Inbar Ben-Zvi, David Karasik: Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies (Curr Osteoporos Rep .)
GWAS, as a largely correlational analysis, requires in vitro or in vivo validation. Zebrafish (Danio rerio) have many advantages for studying the genetics of human diseases. Since gene editing in zebrafish has been highly valuable for studying embryonic skeletal developmental processes that are prenatally or perinatally lethal in mammalian models, we are reviewing pros and cons of this model.
Nadra Naser Samra, Hanna Mandel: Lisch epithelial corneal dystrophy is caused by heterozygous loss-of-function variants in MCOLN1: Molecular basis of Lisch epithelial corneal dystrophy (Am J Ophthalmol .)
Purpose: To report the genetic etiology of Lisch epithelial corneal dystrophy (LECD).
Ran Handel, Yotam Peleg: Real-Time Artificial Intelligence-Based Guidance of Echocardiographic Imaging by Novices: Image Quality and Suitability for Diagnostic Interpretation and Quantitative Analysis (Circ Cardiovasc Imaging .)
We aimed to assess in a prospective multicenter study the quality of echocardiographic exams performed by inexperienced users guided by a new artificial intelligence software and evaluate their suitability for diagnostic interpretation of basic cardiac pathology and quantitative analysis of cardiac chamber and function.
The effect of oral probiotics on glycemic control of women with gestational diabetes mellitus - multicenter, randomized, double blind, placebo controlled trial (Am J Obstet Gynecol MFM)
Gestational diabetes mellitus (GDM) should be treated adequately in order to avoid maternal hyperglycemia-related complications. Previously, probiotic supplements were suggested to improve fasting blood glucose in women with GDM. Yet, a major limitation of previous studies was that pre-prandial and especially post-prandial glucose values, which are important predictors of pregnancy outcomes, were not studied.
(Yuri Perlitz, Lilach Yacov Shavit, Galit Magril, Noa Harel, Sofia Soltsman, Enav Yefet)
Inshirah Sgayer, Maskit Shmueli, Lior Lowenstein, Maya Frank Wolf: Colposcopy-A Valuable Diagnostic Tool for Pregnant Women With Unexplained Vaginal Bleeding (J Low Genit Tract Dis .)
We aimed to examine the diagnostic value of colposcopy in a large cohort of pregnant women with unexplained vaginal bleeding during the second or third trimester.
Avi Benov: The Association Between Glasgow Coma Scale Scores and PTSD in Military Trauma Casualties: Does Mental Status Following Injury Play a Role in PTSD Development? (Mil Med . )
Posttraumatic stress disorder (PTSD) is prevalent among military personnel and may arise following a wide range of traumatic exposures. Consciousness level following traumatic injury may play a role in the development of PTSD, but its effects have been primarily investigated in the context of traumatic brain injury.
Inshirah Sgayer, Gabriel Shamalov, Silas Assi, Daniel Glikman, Lior Lowenstein, Maya Frank Wolf: Bacteriology and clinical outcomes of urine mixed bacterial growth in pregnancy (Int Urogynecol J .)
The objective was to analyse the risk of significant bacteriuria in repeat urine cultures from pregnant women, following initial mixed bacterial results.
Chaim Putterman; Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum (J Autoimmun . )
The difficulty of monitoring organ-specific pathology in systemic lupus erythematosus (SLE) often complicates disease prognostication and treatment. Improved non-invasive biomarkers of active organ pathology, particularly lupus nephritis, would improve patient care. We sought to validate and apply a novel strategy to generate the first comprehensive serum proteome of a lupus mouse model and identify mechanism-linked lupus biomarker candidates for subsequent clinical investigation.
Moshe Carmel, Basem Hijazi, Narges Azzam, Tawfik Khoury, Amir Mari: Chicago Classification Version 4.0 Improves Stratification of Ineffective Esophageal Motility Patients into Clinically Meaningful Subtypes: A Two-Center International Study (Dysphagia )
The 4th iteration of the Chicago Classification (CC v4.0) for esophageal motility disorders offers more restrictive criteria for the diagnosis of Ineffective Esophageal Motility (IEM) compared to version 3.0 (CC v3.0). In light of the updated criteria for IEM, we aimed to characterize and compare the patients who retained their IEM diagnosis to those who were reclassified as normal motility, and to evaluate the clinical impact of the newly introduced CC v4.0.
Tomer Bernstine, Michael Edelstein, Danna Krupik: Pediatric injury attendances in different population groups in Israel before, during, and after COVID-19 lockdowns: a descriptive study, 2018-2022 (Int J Emerg Med .)
Lockdowns and quarantines during the COVID-19 pandemic influenced healthcare services' usage patterns such as emergency department (ED) attendance. During the pandemic, Israel issued three lockdowns (March-May 2020, September-October 2020, and December 2020-February 2021) to mitigate the spread of COVID-19. Little is known about the impact of these lockdowns on ED attendance for injuries in the diverse population of Northern Israel.
Nasser Sakran: Malnutrition Following One-Anastomosis Gastric Bypass: a Systematic Review (Obes Surg . )
Severe malnutrition following one-anastomosis gastric bypass (OAGB) remains a concern. Fifty studies involving 49,991 patients were included in this review.