Recent Publications

Women with low-risk endometrial cancer, as defined by the Korean Gynecologic Oncology Group (KGOG) criteria, have a low risk of lymph node metastasis and an excellent prognosis without lymphadenectomy. However, it is unclear whether lymphadenectomy should be performed in premenopausal women who meet the KGOG criteria other than elevated cancer antigen 125 (CA125) levels, because the CA125 level can be elevated by benign conditions. We investigated the patterns of metastasis and recurrence to assess the value of lymphadenectomy in this population.

Assessing maternal pain and satisfaction following administration of paracetamol vs. placebo prior to catheter balloon placement.

(Maya Frank Wolf, Inshirah Sgayer, Raneen Abu Shqara, Karina Naskovica, Fatina Kassis, Nataly Kushnir, Miri Lavinsky, Nasra Idilbi, Lior Lowenstein)

This study was conducted to evaluate the time gap between earliest head CT with a significant Radscale score and ventriculo-peritoneal (VP) shunt placement.

A low risk of cardiovascular and metabolic outcomes was found in the randomized clinical trials of dupilumab in atopic dermatitis (AD). Dupilumab-associated real-life long-term cardiometabolic risk relative to other systemic agents is yet to be precisely investigated. Objective: To assess the risk of cardiometabolic outcomes in patients with AD treated with dupilumab relative to those treated with methotrexate and cyclosporine.

Performing colonoscopy in the elderly is associated with unique challenges, including higher rates of comorbidities, limited physiological reserve, and procedural complexities. This study aimed to evaluate the technical aspects, indications, and outcomes of colonoscopy in the elderly, with an emphasis on indication-based diagnostic yield. 

Hepatitis E virus (HEV) is one of the most common causes of viral hepatitis. We examined HEV seroprevalence and associations of sociodemographic and lifestyle characteristics with HEV immunoglobulin G (IgG) seropositivity in the Arab population.

Proper alignment of the teeth not only aids in functional occlusion but also promotes harmonious gingival contours, potentially reducing the risk of inflammation and gingival recession. This case series aimed to evaluate the effectiveness of optimizing axial inclination through clear aligner orthodontic treatment in addressing gingival recession defects. 

Evaluates pregnant women's intentions to deliver with labor epidural analgesia (LEA) and identify factors influencing decision-making in a diverse population in northern Israel.

(Raneen Abu Shqara, Gabriela Goldinfeld, Sari Nahir Biderman, Tatiana Sher Brodsky, Asal Darwish, Nadir Ganem,  Lior Lowenstein, Maya Frank Wolf)

Assess LLMs' proficiency, clarity, and objectivity regarding COVID-19 impacts in pregnancy.

Among the various factors implicated in the pathogenesis of gastroesophageal reflux disease (GERD), visceral hypersensitivity and mucosal resistance have been recently re-evaluated in relation to the increasing phenomenon of proton pump inhibitor failure, particularly in patients with nonerosive reflux disease (NERD). Intensive research has allowed us to understand that noxious substances contained in the refluxate are able to interact with esophageal epithelium and to induce the elicitation of symptoms.

Provoked vulvodynia (PV) is the leading cause of vulvar pain and dyspareunia. The etiology of PV is multifactorial and remains poorly understood. PV is associated with a history of repeated vulvar inflammation and is often accompanied by sensory neuromodulation as a result of activation of the metabotropic glutamate receptor 5 (mGluR5) in the sensory nerve terminals. Therefore, this study aims to examine the role of glutamate-mGluR5 signaling during the initial inflammatory phase in chronic vulvar pain development in an animal model of PV.

The study by Njie et al. provides a crucial evaluation of the gaps in the diagnosis and management of eosinophilic esophagitis (EoE) using recently established quality indicators (QIs). By leveraging a multicenter, retrospective design, the authors highlight significant disparities in care and propose a data-driven framework for improving adherence to best practices. Their findings expose weaknesses in clinical practice, particularly in the underutilization of biopsies during initial food impaction, inconsistencies in long-term monitoring, and the variable implementation of evidence-based management strategies. These gaps suggest systemic issues that, if left unaddressed, could compromise patient outcomes and increase the burden of EoE-related complications.

Septic arthritis occurring in the temporomandibular joint (TMJ) has received significantly less attention than it deserves. 

Autoimmune diseases are complex conditions characterized by immune-mediated tissue damage and chronic inflammation. Protease-activated receptor 2 (Par2) has been implicated in these diseases, exhibiting dual roles that complicate its therapeutic potential. This review examines the perplexing functions of Par2, which promotes inflammation through immune cell activation while facilitating tissue healing in damaged organs. 

Post-cesarean delivery (CD) acute pain may progress to chronic pain, which may impair maternal bonding and child development.^1,2 In 2013, we compared the efficacy of versus on-demand oral analgesia for post-caesarean pain in a randomized-controlled-trial.³ The fixed-time-interval group had received scheduled paracetamol, tramadol, and diclofenac regardless of pain level, and the on-demand group received medication as needed, with oxycodone reserved for unrelieved pain in both groups. We found that The 'fixed-time-interval' group had lower pain scores, higher satisfaction rate and more breastfeeds.⁴ We aimed to assess the long-term effects of the study protocols on maternal chronic pain and child development.