Recent Publications
Inshirah Sgayer, Shirin Dabbah, Rola Khamisy Farah, Maya Wolf, Nadine Ashkar, Lior Lowenstein, Marwan Odeh: Spontaneous Rupture of the Unscarred Uterus: A Review of the Literature (Obstet Gynecol Surv .)
Uterine rupture is defined as a nonsurgical disruption of all layers of the uterus. Most ruptures occur in the presence of a scar, usually secondary to a previous cesarean delivery. Rupture of an unscarred uterus is rare and is associated with severe maternal and neonatal outcomes. Objective: To outline the literature on potential predisposing factors, clinical findings, and maternal and fetal outcomes of a rupture of an unscarred uterus.
Shemy Carasso: Transcatheter Edge to Edge Mitral Valve Repair for Mitral Regurgitation in Hypertrophic Cardiomyopathy - A Case Series (Can J Cardiol . )
Mitral valve transcatheter edge to edge repair (TEER) is safe and beneficial in patients with severe mitral regurgitation (MR). Recently, TEER has been suggested as an alternative to surgery in patients with symptomatic hypertrophic obstructive cardiomyopathy (HOCM) and severe MR who are at high risk for septal reduction surgery (1, 2, 3, 4). We present five HOCM patients who underwent TEER. MR severity decreased to mild in all patients and left ventricular outflow (LVOT) maximal gradient decreased from 140±46 to 8±5mmHg immediately after TEER, and to 41±32mmHg at 4±2-month follow-up. All patients reported clinical improvement of their symptoms to NYHA Functional Class I-II.
Nasser Sakran: Early outcomes of one-anastomosis gastric bypass in the elderly population at high-volume bariatric centers (Updates Surg . )
The increasing rate of obesity and life expectancy will lead to increasing numbers of bariatric procedures in the elderly. We aim to report the early (≤ 30 days) adverse events of One-Anastomosis Gastric Bypass (OAGB) in this patient population
Maayan Gruber: Management of Pediatric Foreign Body Injuries during the COVID-19 Pandemic: Results of an International Survey (Children (Basel) . )
The COVID-19 pandemic has had direct and indirect effects on daily life. In hospitals, the impact of the pandemic was observed in the diagnostic and therapeutic workflow. In this work, we explored potential changes in activities related to the treatment of foreign body injuries (FBIs) in children and the behavioral habits of physicians during the first wave of the pandemic.
Nasser Sakran: Nonhepatic hyperammonemic encephalopathy following bariatric surgery: A systematic review (Obes Res Clin Pract .)
Nonhepatic Hyperammonemic encephalopathy (NHAE) following Bariatric Surgery (BS), mainly Roux-en-Y Gastric Bypass (RYGB) and Biliopancreatic Diversion (BPD) is a potentially devastating condition if not diagnosed and managed promptly.
Hyperbaric Oxygen Therapy Alleviates Memory and Motor Impairments Following Traumatic Brain Injury via the Modulation of Mitochondrial-Dysfunction-Induced Neuronal Apoptosis in Rats (Antioxidants (Basel) . )
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young adults, characterized by primary and secondary injury. Primary injury is the immediate mechanical damage, while secondary injury results from delayed neuronal death, often linked to mitochondrial damage accumulation. Hyperbaric oxygen therapy (HBOT) has been proposed as a potential treatment for modulating secondary post-traumatic neuronal death. However, the specific molecular mechanism by which HBOT modulates secondary brain damage through mitochondrial protection remains unclear.
(Reem Sakas, Katya Dan, Saher Abu-Ata, Aviv Ben-Menashe, Yaseen Awad-Igbaria, Jean Francois-Soustiel, Eilam Palzur)
Inshirah Sgayer, Marwan Odeh, Maya Frank Wolf, Ala Aiob , Lior Lowenstein: The impact on pregnancy outcomes of late-onset gestational diabetes mellitus diagnosed during the third trimester: A systematic review and meta-analysis (Int J Gynaecol Obstet .)
Evidence is inconsistent regarding the impact of late gestational diabetes mellitus (GDM) on perinatal outcomes. Objectives: To evaluate associations of GDM diagnosed in the third trimester (late GDM) with adverse obstetric and neonatal outcomes.
Yaseen Awad-Igbaria, Saher Abu-Atta, Yara Nakhleh-Francis, Lior Lowenstein, Jacob Bornstein, Eilam Palzur:Exploring venlafaxine effects on chronic vulvar pain: Changes in mood and pain regulation networks (Neuropharmacology .)
The etiology of idiopathic pain conditions, such as Provoked vulvodynia (PV), is multifactorial. The efficiency of venlafaxine, serotonin-noradrenaline reuptake inhibitor (SNRIs) in modulating vulvar pain led to the hypothesis that PV might involve central mechanisms. Here, we investigate whether vulvar pain is associated with gene-expression changes in mood, stress and pain systems, including amygdala (Amg), medial prefrontal cortex (mPFC), and periaqueductal gray matter (PAG).
Detection and dissection of sentinel nodes in endometrial endometrioid cancer with indocyanine green using PinPoint laparoscopy: Analysis of the learning curve (Eur J Obstet Gynecol Reprod Biol . )
Early-stage endometrial endometrioid adenocarcinoma is managed through laparoscopic total hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Detection of positive nodes is rare, and lymphadenectomy may involve complications. Pelvic sentinel lymph node dissection can prevent complete dissection. Herein, we evaluated the learning curve of sentinel lymph node dissection using indocyanine green.
(Avishalom Sharon, Ala Aiob, Mohammad Kais, Liat Apel-Sarid, Renee Tendler, Grigory Dourleshter, Jacob Bornstein)
Inbar Ben-Zvi, David Karasik: Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies (Curr Osteoporos Rep .)
GWAS, as a largely correlational analysis, requires in vitro or in vivo validation. Zebrafish (Danio rerio) have many advantages for studying the genetics of human diseases. Since gene editing in zebrafish has been highly valuable for studying embryonic skeletal developmental processes that are prenatally or perinatally lethal in mammalian models, we are reviewing pros and cons of this model.
Lior Segev, Abraham O Samson:Combined Hormonal Contraception during Breastfeeding-A Survey of Physician's Recommendations (J Clin Med .)
Until breastfeeding is established, progesterone-only pill (POP) use is preferable over combined hormonal contraception (CHC), as the latter potentially reduces milk production. Yet, POPs are often associated with breakthrough bleeding (BTB), and irregular spotting is often a reason for their cessation. Conversely, CHC is less associated with BTB but is not usually prescribed, even if breastfeeding has been established, despite its verified safety profile. Here, we surveyed physicians' perception of CHC safety during breastfeeding through an online questionnaire (N = 112).
Naaem Simaan: Automated CT perfusion analysis reveals medial temporal perfusion abnormalities during transient global amnesia (J Neurol Sci .)
The underlying pathophysiology of Transient global amnesia (TGA) remains elusive. Reports of perfusion abnormalities in TGA were inconsistent, but semi-automated analysis of perfusion CT (CTP) may improve reliability and precision of perfusion deficit detection.
Nadra Naser Samra, Hanna Mandel: Lisch epithelial corneal dystrophy is caused by heterozygous loss-of-function variants in MCOLN1: Molecular basis of Lisch epithelial corneal dystrophy (Am J Ophthalmol .)
Purpose: To report the genetic etiology of Lisch epithelial corneal dystrophy (LECD).
Ran Handel, Yotam Peleg: Real-Time Artificial Intelligence-Based Guidance of Echocardiographic Imaging by Novices: Image Quality and Suitability for Diagnostic Interpretation and Quantitative Analysis (Circ Cardiovasc Imaging .)
We aimed to assess in a prospective multicenter study the quality of echocardiographic exams performed by inexperienced users guided by a new artificial intelligence software and evaluate their suitability for diagnostic interpretation of basic cardiac pathology and quantitative analysis of cardiac chamber and function.
The effect of oral probiotics on glycemic control of women with gestational diabetes mellitus - multicenter, randomized, double blind, placebo controlled trial (Am J Obstet Gynecol MFM)
Gestational diabetes mellitus (GDM) should be treated adequately in order to avoid maternal hyperglycemia-related complications. Previously, probiotic supplements were suggested to improve fasting blood glucose in women with GDM. Yet, a major limitation of previous studies was that pre-prandial and especially post-prandial glucose values, which are important predictors of pregnancy outcomes, were not studied.
(Yuri Perlitz, Lilach Yacov Shavit, Galit Magril, Noa Harel, Sofia Soltsman, Enav Yefet)