Recent Publications
Uriel Trahtemberg: Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia (Crit Care .)
Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improve our understanding of ARDS, including its molecular mechanisms, individualized treatment options, and potential interventions to reduce inflammation and promote lung repair. Objective: To map and compare metabolic phenotypes of different infectious causes of ARDS to better understand the metabolic pathways involved in the underlying pathogenesis.
Rotem Kahalon: Exploring women's strong preference for women surgeons in breast healthcare (World J Surg . )
This study challenges the prevalent belief that surgical roles demand masculine traits, potentially limiting women's suitability for such positions. Contrary to this stereotype, we explored the hypothesis that in sensitive surgical procedures, where communal traits are valued, women patients might favor women surgeons. Two experimental studies investigated women's preferences for a man versus a woman surgeon in a breast exam and breast surgery.
Adi Eshel, Lelyan Moadi, Sondra Turjeman, Omry Koren: Children with idiopathic short stature have significantly different gut microbiota than their normal height siblings: a case-control study (Front Endocrinol (Lausanne) .)
Objectives: To investigate the role of gut microbiota (GM) in pathogenesis of idiopathic short stature (ISS) by comparing GM of ISS children to their normal-height siblings.
Liron Leibovitch: Short Versus Regular Periods of Cast Immobilization for Distal Radial Fractures: A Systematic Review and Meta-Analysis (Cureus . )
The current research on the recommended durations for cast immobilization in adults with distal radial fractures (DRFs) lacks a clear consensus or definitive conclusion. The standard practice involves casting immobilization for five to six weeks. The debate revolves around the potential benefits of shorter periods (three to four weeks) without compromising patient outcomes. While previous research has delved into this subject through systematic reviews, our study stands out by conducting a meta-analysis, aiming for a more precise understanding of whether short or regular cast immobilization duration proves more effective for treating DRFs. A systematic search was conducted across PubMed, Embase, and the Cochrane Library databases to identify relevant studies.
Alaa Safia, Rabie Shehadeh, Shlomo Merchavy: Anterolateral Lingual Abscess in a Young Adult: A Comprehensive Case Study (Ear Nose Throat J . )
Lingual abscesses, characterized by infectious collections of pus within the tongue parenchyma, are rare and poorly understood clinical entities. Despite their potential for severe complications, literature on lingual abscesses remains limited, consisting mainly of sporadic case reports. This comprehensive case study examines the challenges and successful management of a severe anterolateral tongue abscess in a young adult, contributing to the emerging body of knowledge on this condition.
Karl Skorecki: Moral clarity at WHO needs to be clearer (Lancet . )
In the Offline entitled The moral clarity of WHO's Director-General, Richard Horton highlights Tedros Adhanom Ghebreyesus' “ethical leadership” and supports his anguished calls for a complete cessation to hostilities in Gaza....However, unlike Richard Horton, we believe that Tedros' statements fall woefully short.
Shiran Sudri, Dalit Porat Ben Amy, Wadie Abu Dahoud, Imad Abu El-Naaj: Pediatric Trauma During COVID-19: What Have We Learned? (J Oral Maxillofac Surg .)
In December 2019, an outbreak of a novel pneumonia-like illness, COVID-19 (C-19), emerged in Wuhan, China. In March 2020, as the incidence of C-19 rose, the Israeli government, like that of other nations, declared a national state of emergency, and a full, general lockdown was announced. The purpose of this study is to determine the incidence and characteristics of pediatric maxillofacial trauma presentation during the 2020 C-19 lockdown restrictions and compare them to periods outside lockdown between 2019 and 2020 (pre-C-19).
Nasser Sakran: 30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE): A Prospective, International Collaborative Cohort Study (Ann Surg . )
This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications.
Nadine Ashkar Majadla, Raneen Abu Shqara, Maya Frank Wolf, Ruba Tuma, Lior Lowenstein, Marwan Odeh: The role of the cerebroplacental ratio in predicting pregnancy outcomes at 40-42 gestational weeks: a prospective observational trial (Arch Gynecol Obstet
The cerebroplacental ratio is a sonographic tool used to predict poor pregnancy outcomes. Data are insufficient regarding its use in postdate pregnancy. We evaluated the cerebroplacental ratio's prediction of unfavorable pregnancy outcomes in women at 40-42 weeks gestation with normal amniotic fluid index.
Omry Koren: Gut microbiome-metabolome interactions predict host condition (Microbiome. )
The effect of microbes on their human host is often mediated through changes in metabolite concentrations. As such, multiple tools have been proposed to predict metabolite concentrations from microbial taxa frequencies. Such tools typically fail to capture the dependence of the microbiome-metabolite relation on the environment.
Shemy Carasso: Sex difference and outcome trends following surgical aortic valve replacement from the National Inpatient Sample (NIS) Database (J Cardiovasc Surg (Torino) . )
Based on worldwide registries, approximately 50% of patients who underwent aortic valve replacement (AVR) via surgical aortic valve replacement are females. Although AVR procedures have improved greatly in recent years, differences in outcome including mortality between sexes remain. We aimed to investigate the trends in SAVR outcomes in females versus males.
Tatiana Smolkinת Vered Fleisher Sheffer, Tzipora C Falik-Zaccai, Hussam Omari, Igor Portnov, Nadra Nasser Samra: National Rapid Genome Sequencing in Neonatal Intensive Care (JAMA Netw Open .)
Evaluates the feasibility, diagnostic efficacy, and clinical utility of rtGS in neonatal intensive care units (NICUs) throughout Israel.
Tal Sneh, Hava Gil-Henn: Antibody-drug conjugate αEGFR-E-P125A reduces triple-negative breast cancer vasculogenic mimicry, motility, and metastasis through inhibition of EGFR, integrin, and FAK/STAT3 signaling (Cancer Res Commun . )
Primary tumor growth and metastasis in triple-negative breast cancer (TNBC) require supporting vasculature, which develop through a combination of endothelial angiogenesis and vasculogenic mimicry (VM), a process associated with aggressive metastatic behavior in which vascular-like structures are lined by tumor cells. We developed αEGFR-E-P125A, an antibody-endostatin fusion protein that delivers a dimeric, mutant endostatin (E-P125A) payload that inhibits TNBC angiogenesis and VM in vitro and in vivo.
Ofri Tsafrir, Hanan Rohana, Lior Bousani, Khatib Orsan, Said Abozaid, Maya Azrad, Avi Peretz: Clinical isolate characteristics and demographics of patients with C.jejuni and C.coli infections in Northern Israel, 2015-2021 (Epidemiol Infect . )
C.coli is a significant cause of foodborne gastroenteritis worldwide, with the majority of cases attributed to C.jejuni. Although most clinical laboratories do not typically conduct antimicrobial susceptibility testing for C.coli, the rise in resistant strains has underscored the necessity for such testing and epidemiological surveillance. The current study presents clinical isolate characteristics and demographics of 221 patients with C.coli (coli and jejuni) infections in Northern Israel, between 2015 and 2021.