חדשות המחקר
Daniel Kovarsky, Adi Shani, Alon Rod, Dan Ciubotaru, Nimrod Rahamimov: Effectiveness of intra-venous steroids for preventing surgery for lumbo-sacral radiculopathy secondary to intervertebral disc herniation: a retrospective study of 213 patients (Sci Rep
The natural history of lumbar disc herniation with radiculopathy is favorable, with 95% of patients expected to be pain-free within 6 months of onset. Despite the favorable prognosis, operative treatment is often chosen by patients unable to "ride out" the radicular episode. Prospective studies comparing surgical with non-surgical treatment have demonstrated similar long-term results. We conducted a retrospective case-series study of patients with a lumbar disc herniation and intractable radicular pain without significant neurological deficits treated with intra-venous dexamethasone.
Nasser Sakran: Epicardial adipose tissue, obesity and the occurrence of atrial fibrillation: an overview of pathophysiology and treatment methods (Expert Rev Cardiovasc Ther .)
Obesity is a chronic disease, which has significant health consequences and is a staggering burden to health care systems. Obesity can have harmful effects on the cardiovascular system, including heart failure, hypertension, coronary heart disease, and atrial fibrillation (AF). One of the possible substrates might be epicardial adipose tissue (EAT), which can be the link between AF and obesity. EAT is a fat deposit located between the myocardium and the visceral pericardium. Numerous studies have demonstrated that EAT plays a pivotal role in this relationship regarding atrial fibrillation. This review will focus on the role of obesity and the occurrence of atrial fibrillation (AF) and examine the connection between these and epicardial adipose tissue (EAT).
Reema Fadoul, Tharwat Haj Khalil, Idan Redenski, Daniel Oren, Asaf Zigron, Avishalom Sharon, Amiel A Dror, Mizied Falah, Samer Srouji:The Modulatory Effect of Adipose-Derived Stem Cells on Endometrial Polyp Fibroblasts (Stem Cells Dev .)
Endometrial polyps (EPs) are benign overgrowths of the endometrium, with the potential to cause severe complications, ranging from discomfort to inflammation and infertility. Dysfunction of endometrial fibroblasts may be a critical component leading to the development of polyps. While surgical intervention is the common remedy for severe cases, it comes with drawbacks, including infection, bleeding, and risk of damage to the cervix and adjacent tissues. Adipose-derived mesenchymal stromal cells (ASCs) are at the focus of modern medicine, as key modulators of tissue homeostasis, inflammation and tissue repair, rendering them prime candidate agents for tissue regeneration and cell-based therapies. In the current work, endometrial polyps were isolated from patients admitted to the OB/GYN department at the Galilee Medical Center and extracted fibroblasts (EPFs) were isolated and characterized...
Idan Segal, Nadra Nasser Samra:De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway (HGG Adv . )
CSNK2B encodes for casein kinase II subunit beta (CK2β), the regulatory subunit of casein kinase II (CK2), which is known to mediate diverse cellular pathways. Variants in this gene have been recently identified as a cause of Poirier-Bienvenu neurodevelopmental syndrome (POBINDS), but functional evidence is sparse. Here, we report five unrelated individuals: two of them manifesting POBINDS, while three are identified to segregate a new intellectual disability-craniodigital syndrome (IDCS), distinct from POBINDS.
Boris Fichtman, Amnon Harel: High-Resolution Imaging and Analysis of Individual Nuclear Pore Complexes (Methods Mol Biol .)
Field emission scanning electron microscopy (FESEM) is a well-established technique for acquiring three-dimensional surface images of nuclear pore complexes (NPCs). We present an optimized protocol for the exposure of mammalian cell nuclei and direct surface imaging of nuclear envelopes by FESEM, allowing for a detailed morphological comparison of individual NPCs, without the need for averaging techniques.
Vertical transmission and humoral immune response following maternal infection with SARS-CoV-2 - A prospective multicenter cohort study (Clin Microbiol Infect .)
Explores maternal humoral immune responses to SARS-CoV-2 infection and the rate of vertical transmission.
(Manal Massalha, Enav Yefet, Orit Rozenberg, Sofia Soltsman, Jamal Hasanein, Tatiana Smolkin, Adi Alter, Yuri Perlitz, Zohar Nachum)
Trishna Saha Detroja, Hava Gil-Henn, Abraham O Samson: Text-Mining Approach to Identify Hub Genes of Cancer Metastasis and Potential Drug Repurposing to Target Them (J Clin Med . )
Metastasis accounts for the majority of cancer-related deaths. Despite decades of research, the prevention and suppression of metastasis remain an elusive goal, and to date, only a few metastasis-related genes have been targeted therapeutically. Thus, there is a strong need to find potential genes involved in key driver traits of metastasis and their available drugs. In this study, we identified genes associated with metastasis and repurposable drugs that potentially target them.
Naaem Simaan: Effects in Israel of Arab and Jewish Ethnicity on Intracerebral Hemorrhage (J Clin Med . )
Intracerebral hemorrhages (ICH) characteristics reportedly differ between different ethnic groups. We aimed to compare the characteristics of Jewish and Arab ICH patients in Israel.
Rola Khamisy-Farah: How to Integrate Sex and Gender Medicine into Medical and Allied Health Profession Undergraduate, Graduate, and Post-Graduate Education: Insights from a Rapid Systematic Literature Review and a Thematic Meta-Synthesis (J Pers Med . )
Sex and gender are concepts that are often misunderstood and misused, being utilized in a biased, preconceived, interchangeable way. Sex and gender medicine is generally overlooked, despite the profound impact of sex and gender on health outcomes. The aims of the present rapid systematic literature review were (i) to assess the extent to which sex- and gender-sensitive topics are covered in medical courses; (ii) to assess the need for and willingness toward integrating/incorporating sex and gender medicine into health-related education; (iii) to identify barriers and facilitators of the process of implementation of sex and gender medicine in medical teaching, mentoring, and training; and (iv) to evaluate the effectiveness of interventional projects targeting curriculum building and improvement for future gender-sensitive physicians.
Ligat Shalev, Anthony Luder, Sivan Spitzer, Danna Krupik, Jumanah Essa-Hadad, Mary C J Rudolf: Keeping our children safe: piloting a hospital-based home-visitation program in Israel (Isr J Health Policy Res)
Unintentional childhood injuries are a leading cause of morbidity and mortality worldwide. Attempts to prevent child home injuries have rarely been implemented in hospital settings which present an important opportunity for intervention. The SHABI ('Keeping our Children Safe; SHomrim Al BetIchut Yeladenu') program recruits at-risk families presenting with child injury to the Emergency Department. Medical/nursing students conduct two home visits and provide safety equipment and guidance. The objective of this study was to investigate the impact of SHABI on participating families' home-safety.
Kamal Abu Jabal, Michael Edelstein: Using SARS-CoV-2 anti-S IgG levels as a marker of previous infection: Example from an Israeli Healthcare worker cohort (Int J Infect Dis .)
Determining COVID19 status is important for global epidemiology and individual-level vaccination decision-making. SARS CoV-2 Infection can generally only be detected during a 7-10 days period using PCR or rapid antigen testing, and infection specific anti nucleocapsid IgG assays are not universally available. We determined whether SARS-CoV-2 anti spike (anti-S) IgG levels could discriminate between vaccination and past infection when interpreted alongside vaccination timing.
Inbar Ben Shachar, Ilan Atlas: Does sentinel lymph node biopsy in endometrial cancer surgery have an impact on the rate of adjuvant post operative pelvic radiation? An Israeli Gynecologic Oncology Group Study (Gynecol Oncol Rep. )
Compares the rates of post-operative radiotherapy between two methods of lymph nodes assessment during surgical staging for endometrial cancer (EC).
Hagar Mizrachi: Cuffing Prisoners and Detainees in Israeli Hospitals - a Multi-center Study (Harefuah .)
Describes the extent of prisoner/detainee cuffing and characterize cuffing methods.
Yana Lerner, Surya Sukumaran, Nir Qvit: Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology (J Vis Exp .)
Biomolecular interactions play versatile roles in numerous cellular processes by regulating and coordinating functionally relevant biological events. Biomolecules such as proteins, carbohydrates, vitamins, fatty acids, nucleic acids, and enzymes are fundamental building blocks of living beings; they assemble into complex networks in biosystems to synchronize a myriad of life events. Proteins typically utilize complex interactome networks to carry out their functions; hence it is mandatory to evaluate such interactions to unravel their importance in cells at both cellular and organism levels. Toward this goal, we introduce a rapidly emerging technology, field-effect biosensing (FEB), to determine specific biomolecular interactions. FEB is a benchtop, label-free, and reliable biomolecular detection technique to determine specific interactions and uses high-quality electronic-based biosensors.
Rajesh Detroja, Sumit Mukherjee, Milana Frenkel-Morgenstern: The Landscape of Novel Expressed Chimeric RNAs in Rheumatoid Arthritis (Cells. )
In cancers and other complex diseases, the fusion of two genes can lead to the production of chimeric RNAs, which are associated with disease development. Several recurrent chimeric RNAs are expressed in different cancers and are thus used for clinical cancer diagnosis. Rheumatoid arthritis (RA) is an immune-mediated joint disorder resulting in synovial inflammation and joint destruction. Despite advances in therapy, many patients do not respond to treatment and present persistent inflammation. Understanding the landscape of chimeric RNA expression in RA patients could provide a better insight into RA pathogenesis, which might provide better treatment strategies and tailored therapies. Accordingly, we analyzed the publicly available RNA-seq data of synovium tissue from 151 RA patients and 28 healthy controls and were able to identify 37 recurrent chimeric RNAs found to be expressed in at least 3 RA samples