חדשות המחקר
Effects of hemodialysis with cooled dialysate on high-sensitive cardiac troponin I and brain natriuretic peptide (Hemodial Int .)
Hemodialysis (HD) triggers recurrent and cumulative ischemic insults to the brain and the heart. Cooled dialysate may have a protective effect on major organs and improve hemodynamic tolerability of dialysis. The aim of the study was to compare HD with cooled dialysate with routine dialysis in terms of hemodynamic stability and levels of high-sensitivity Troponin I (hs-TnI) and N-terminal pro b-type natriuretic peptide (NTproBNP) pre and postdialysis.
(Younes Bathish, Karine Beiruti, Hussein Safadi, Adi Sharabi Nov, Elena Bukovetzky, Michael Edelstein, Majdi Halabi, Zeev Israeli)
Challenges in abdominal re-exploration for war casualties following on-site abdominal trauma surgery and subsequent delayed arrival to definitive medical care abroad - an unusual scenario (BMC Emerg Med . )
During the Syrian civil war, patients were initially treated on-site in Syria and later transferred to medical centers in Israel. Relevant details concerning the exact nature of injury and medical/surgical care received in Syria were unavailable to clinicians in Israel. Many of these patients required abdominal re-exploration for obvious or suspected problems related to their injury. Our aim is to present our approach to abdominal trauma patients who survived initial on-site surgery and needed subsequent abdominal re-exploration abroad, in our medical center.
(Amitai Bickel, Konstantin Akinichev, Michael Weiss, Samer Ganam, Seema Biswas, Igor Waksman, Eli Kakiashvilli)
Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated MyositisVaccines (Basel) .)
Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure.
(Sumit Mukherjee, Mahua Bhattacharya, Rajesh Detroja, Gideon Baum, Milana Frenkel-Morgenstern)
Should pregnant women be screened for SARS-CoV-2 infection? A prospective multicenter cohort study (Int J Gynaecol Obstet . )
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranges from asymptomatic to severe infection. We aimed to compare the prevalence of COVID-19 in asymptomatic pregnant vs. non-pregnant women in order to establish recommendations for a COVID-19 screening strategy.
(Enav Yefet, Manal Massalha, Adi Alter, Amit Gal Harnik, Sally Hosari Mahamed, Lia Novick, Malak Wattad, Jawad Sakas, Shira Baram, Amir Weiss, Rula Iskander, Avi Peretz, Johnny S Younis, Yuri Perlitz, Zohar Nachum)
Radi Shahien, Karine Beiruti Wiegler, Lior Dekel, Adi Sharabi-Nov, Saad Abu Saleh: Retrospective study assessing the efficacy of i.v. dexamethasone, SNRB, and nonsteroidal treatment for radiculopathy (Medicine (Baltimore) .)
The purpose of this study was to investigate the clinical symptomatology of discopathies before and 7 days after treatment with one of the following: intravenous dexamethasone, selective nerve root block (SNRB), and systemic treatment with different nonsteroidal antiinflammatory drugs (NSAIDs).
Hadas Shasha-Lavsky: Lumasiran for Advanced Primary Hyperoxaluria Type 1: Phase 3 ILLUMINATE-C Trial (Am J Kidney Dis . )
Lumasiran reduces urinary and plasma oxalate (POx) in patients with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function. ILLUMINATE-C evaluates the efficacy, safety, pharmacokinetics, and pharmacodynamics of lumasiran in patients with PH1 and advanced kidney disease.
Yaseen Awad-Igbaria, Shilo Dadon, Jacob Bornstein, Eilam Palzur: Characterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats (J Inflamm Res .)
Provoked vulvodynia (PV) is the main cause of vulvar pain and dyspareunia. The etiology of PV has not yet been elucidated. However, PV is associated with a history of recurrent inflammation, and its often accompanied by increases in the numbers of mast cells (MCs) and sensory hyperinnervation in the vulva. Therefore, this study aimed to examine the role of MCs and the early inflammatory events in the development of chronic vulvar pain in a rat model of PV.
Fadi Haddad: Changes in chorioretinal flow index after cataract surgery: an optical coherence tomography angiography study (Int Ophthalmol .)
Pseudophakic cystoid macular edema (CME) occurs in up to 2% of uneventful cataract surgeries. This study evaluates changes in macular blood flow succeeding uneventful phacoemulsification cataract extraction among otherwise visually healthy subjects.
Offir Ertracht, Shaul Atar, Dimitry Chuyun, Andrea Szuchman-Sapir: Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation (Prostaglandins Other Lipid Mediat .)
Human serum paraoxonase-1 (PON1) is a lactonase that plays a significant role in anti-atherosclerotic high-density lipoprotein (HDL) activity. PON1 is also localized in endothelial cell membranes, where it is enzymatically active and regulates endothelial signals. PON1 has a high specificity for lipophilic lactones and has been shown to hydrolyze and regulate lactone lipid mediators derived from arachidonic polyunsaturated fatty acids (PUFA). Previously, we showed that an arachidonic acid lactone metabolite (AA-L) dose-dependently dilates PON1 gene deletion (PON1KO) mouse mesenteric arteries significantly more than wild-type arteries. In contrast, preincubation with HDL or rePON1 reduced AA-L-dependent vasodilation. Recently we showed that an additional δ-lactone metabolite derived from the eicosapentaenoic acid lactone, 5,6-δ-DiHETE lactone (EPA-L) reduced blood pressure by dilating microvessels of hypertensive rats. However, whether PON1 regulates the activity of the EPA-L lipid mediator is unknown.
To demonstrate that PON1 hydrolyzes EPA-L and to reveal the effect of this hydrolysis on endothelial-dependent vascular dilation.
Elon Glassberg: Toward a more complete understanding of who will benefit from prehospital transfusion (Transfusion .)
In this commentary, it will be demonstrated that the results of the recently published randomized controlled trials (RCT) that investigated the effects of prehospital transfusion are not necessarily conflicting, but rather they help to establish the nature of the patients who might benefit from prehospital transfusion.
Immunity waning after COVID vaccine booster vs. infection-better than expected (Infect Dis (Lond) . )
Rapid decline in antibody-titres after BNT162b2 mRNA COVID-19 vaccine was reported; thus, a booster dose, and recently a second booster were approved. The study aims to discuss immunogenicity throughout the pandemic, especially after booster dose.
(Johad Khoury, Ronza Najjar-Debbiny, Ameer Elemy, Adel Jabbour, Juliana Haj, Rabah Yasin, Mohammad Amin, Elias Hellou, Najib Nasrallah, Amer Saffouri, Fahed Hakim)
Amir Mari: The Natural History of Esophageal "Absent Contractility" and Its Relationship with Rheumatologic Diseases: A Multi-Center Case-Control Study (J Clin Med .)
Absent contractility (AC) is an esophageal motility disorder defined as a normal integrated relaxation pressure with 100% failed peristalsis. We sought to clarify the natural history of this disorder and its relationship with rheumatologic diseases, such as systemic sclerosis (scleroderma).
Edo Y Birati: Safety and Effectiveness of Intravenous Iron Therapy in Patients Supported by Durable Left Ventricular Assist Devices (J Clin Med .)
While it is common practice to use intravenous (IV) iron in patients with left ventricular assist devices (LVADs) and iron deficiency, there is insufficient evidence regarding outcomes in this patient population. We evaluated the safety and effectiveness of IV iron therapy in patients supported by LVADs with iron deficiency.
Clinical factors and pre-surgical depression scores predict pain intensity in cardiac surgery patients (BMC Anesthesiol .)
Severe pain is prevalent in cardiac surgery patients and can increase cardiac complications, morbidity and mortality. The objectives of the study were to assess perioperative pain intensity and to assess predictors of pain post-cardiac surgery, including clinical characteristics and depression.
(Liza Grosman-Rimon, Noa Caspi-Avissar, Dina Granot, Sagi Gleitman, Jawdat Badarny, Alla Lubovich, Doron Sudarsky, Jordan Rimon, Shemy Carasso, Edo Y Birati, Erez Kachel)
Adnan Zaina:High Prevalence of Acromegaly in Different Industrial Areas: A Population-based Study from Haifa and Western Galilee District in Northern Israel ( Isr Med Assoc J . )
National registries for acromegaly and population-based data make an important contribution to disease understanding and management. Data concerning the epidemiology of acromegaly in Israel is scanty. Evaluates the epidemiology of acromegaly in different industrial areas in northern Israel.