חדשות המחקר
Dana Cohen, Ronen Sloma, Ayalla Fedida, Limor Kalfon, Relli Ovadia, Zvi Segal, Yanir Kassif, Tzippi Falik Zaccai : Long term ophthalmic complications of distal arthrogryposis type 5D (Ophthalmic Genet .)
Distal Arthrogryposis type 5D (DA5D) is a rare genetic disease, expressed phenotypically by skeletal and ocular abnormalities.
Amani Daoud, Netanel Eisenbach, Ohad Ronen, Amiel Dror, Tali Jane Ohayon, Majd Hajouj, Eyal Sela, Tal Marshak: Cross-cultural adaptation of the Hebrew Nasal Obstruction Symptom Evaluation (NOSE) scale (Laryngoscope Investig Otolaryngol . )
Nasal obstruction is a common complaint. The Nasal Obstruction Symptom Evaluation scale (NOSE) is a reliable validated tool used to assess the quality of life of patients with nasal obstruction. The purpose of this study is to validate the Hebrew version of the NOSE scale (He-NOSE).
Tomer Meirson: Systemic review of the robustness of randomized controlled trials for the treatment of cholangiocarcinoma in three domains: survival-inferred fragility index, restricted mean survival time, and the spin effect (Hepatobiliary Surg Nutr .)
The vast majority of patients with cholangiocarcinoma (CC) have advanced disease at diagnosis and are candidates for palliative treatment only. The robustness of the randomized controlled trials regarding the treatment of CC are assessed.
Avi Benov: Combat Injury Profile in Urban Warfare (Mil Med . )
Combat ground maneuvers consist of various platforms and have several environmental characteristics, influenced by the terrain, the operational mission, and the force's capabilities. This study assesses data on injuries sustained during urban warfare, aiming to evaluate the relationship between injury characteristics, maneuver platform, and personal protective gear on the battlefield.
Michael V Robinshaw, Mary Abdo, Kutaiba Alkeesh, Said Abozaid, Imad Abu El-Naaj: Factors associated with prolonged hospitalizations from odontogenic infections in children (J Clin Pediatr Dent)
Oro-facial infections are common pathologies comprising a substantial health concern in the pediatric population. Incorrect or late treatment may lead to serious and possibly life-threatening complications. The aim of this study is to analyze variables associated with prolonged length of hospital stays (LOS) due to odontogenic infections in children.
Liron Rozenkrantz: Association of pessimism with cardiovascular events and all-cause mortality (Prog Cardiovasc Dis .)
Poor psychological health is associated with Takotsubo cardiomyopathy, cardiac syndrome X, coronary microcirculatory dysfunction, peripheral artery disease, or spontaneous coronary artery dissection. Data regarding pessimism, cardiovascular disease (CVD) events and mortality and all-cause mortality remained inconclusive. This systematic review and meta-analysis aim to provide an overview of the association between pessimism, CVD outcomes and mortality.
Yaseen Awad-Igbaria, Eilam Palzur: Blocking the ErbB pathway during adolescence affects the induction of anxiety-like behavior in young adult maternal immune activation offspring (Pharmacol Biochem Behav .)
Epidemiological and experimental evidence demonstrates that maternal exposure to infection during gestation increases the offspring's risk of developing schizophrenia and other neurodevelopmental disorders. In addition, the NRG-ErbB4 signaling pathway is involved in brain development and neuropsychiatric disorders. Specifically, this pathway modulates the dopaminergic and GABAergic systems and is expressed in the early stages of prenatal development. We recently demonstrated that maternal immune activation (MIA) at late gestation altered the expression of NRG1, its receptor ErbB4, and the dopamine D2 receptor four hours post-injection of viral or LPS in the fetal brain. We also reported that blocking the ErbB pathway during adolescence resulted in increased striatal DA content and reduced preference for sweetness and alcohol that persists into adulthood. However...
Khalaf Kridin, Batsheva Ingram, Avi Peretz: Sexually Transmitted Diseases in Northern Israel: Insights From a Large Referral Laboratory ( Low Genit Tract Dis . )
The aims of the study are to investigate the distribution and frequency of different sexually transmitted diseases (STDs) among a large study population of individuals undergoing STD investigation both in inpatient and STD clinic settings and to evaluate influence of test anonymity on the positivity rate of pathogens.
Khalaf Kridin, Noor Mruwat: Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus (JAMA Dermatol . )
The association of different therapeutic approaches with long-term cardiovascular and metabolic outcomes in patients with pemphigus remains to be precisely evaluated. Objective: To assess the risk of long-term cardiovascular and metabolic outcomes and all-cause mortality in patients with pemphigus managed by rituximab compared with those receiving treatment with first-line corticosteroid-sparing agents (azathioprine and mycophenolate mofetil [MMF]).
Hadas Shasha-Lavsky, Aviv Avni, Ziv Paz, Limor Kalfon, Amiel A Dror, Orly Yakir, Tzipora Falik Zaccai, Irith Weissman: Long-term outcomes after pre-emptive liver transplantation in primary hyperoxaluria type 1 (Pediatr Nephrol . )
Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disease caused by the liver defect of oxalate metabolism, which leads to kidney failure and systemic manifestations. Until recently, liver transplantation was the only definitive treatment. The timing of liver transplantation can be early, while kidney function is still normal (pre-emptive liver transplantation-PLT), or when the patient reaches stage 5 chronic kidney disease (CKD) and needs combined liver-kidney transplantation. We aimed to determine the long-term kidney outcomes of PLT in PH1 patients.
Gal Reches, Netta R Blondheim Shraga, Assaf Malka, Natalia Saleev, Yehuda Gubbay, Offir Ertracht, Ron Piran: Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries (Inflamm Regen . )
Different factors may lead to hepatitis. Among which are liver inflammation and poisoning. We chose two hepatitis models, typical for these two underlying causes. Thus, we aimed to characterize the role of protease-activated receptor 2 (Par2) in liver regeneration and inflammation to reconcile Par2 conflicting role in many damage models, which sometimes aggravates the induced damage and sometimes alleviates it.
Hanna Keren: Emotion-related impulsivity and risky decision-making: A systematic review and meta-regression (Clin Psychol Rev . )
Emotion-related impulsivity, the trait-like tendency toward regrettable behavior during states of high emotion, is a robust predictor of internalizing and externalizing psychopathology. Despite substantial evidence that emotion-related impulsivity is important transdiagnostically, relatively little is known about its cognitive correlates. This systematic review and meta-regression investigates one such candidate, risky decision-making.
Nasser Sakran, Kim Soifer, Sharon Soued: Long-term Reported Outcomes Following Primary Laparoscopic Sleeve Gastrectomy (Obes Surg .)
Long-term laparoscopic sleeve gastrectomy (LSG) outcomes in patients with obesity are scarce. We aimed to examine the outcomes and subjective experience of patients who underwent primary LSG with long-term follow-up.
Alon Rubinstein, Eilam Palzur: Long-term effects of prophylactic MgSO4 in maternal immune activation rodent model at adolescence and adulthood (J Neurosci Res .)
The effects of MgSO4 as an anti-inflammatory agent in pregnant women have been investigated in the last few years. Infections can cause an inflammatory reaction involving the placenta membranes and amniotic cavity. They may have short-term effects on the mother and her fetuses, like preterm birth, cerebral palsy, and developmental delay. Despite the alleged advantages of MgSO4 as a neuroprotective agent in the preterm brain, the long-term molecular and behavioral function of MgSO4 has not been fully elucidated. Here, we investigated the long-term effect of antenatal MgSO4 , during late gestation, on offspring's behavior focusing on cognitive function, motor activity, and social cognition in adolescence and adulthood, and explored its influence on brain gene expression (e.g., ErbB signaling, pro-inflammatory, and dopaminergic markers) in adulthood.
Shemy Carasso, Offer Amir: The Battle against Cardiogenic Shock (J Clin Med . )
Cardiogenic shock (CS) is a life-threatening condition characterized by hypoperfusion and hypoxia caused by low cardiac output [...].