חדשות המחקר
Omry Koren: MetaPhlAn 4 profiling of unknown species-level genome bins improves the characterization of diet-associated microbiome changes in mice (Cell Rep .)
Mouse models are key tools for investigating host-microbiome interactions. However, shotgun metagenomics can only profile a limited fraction of the mouse gut microbiome. Here, we employ a metagenomic profiling method, MetaPhlAn 4, which exploits a large catalog of metagenome-assembled genomes (including 22,718 metagenome-assembled genomes from mice) to improve the profiling of the mouse gut microbiome.
Alon Barash: Morphologic aspects of the cervical (C3 to C7) annular epiphysis: a skeletal study (Spine J . )
The annular epiphysis (AE) is a peripheral ring of cortical bone that forms a secondary ossification center in the superior and inferior surfaces of vertebral bodies (VBs). The AE is the last ossification site in the skeleton, typically forming at about the 25th year of life. The AE functions jointly with vertebral endplates to anchor the intervertebral discs to the VBs. Purpose: To establish accurate data on the sizes of the AE of the cervical spine (C3-C7); to compare the ratios between areas and the ratios of the AE to VBs; to compare the ratios between the superior and inferior VB surface areas; and to compare AE lengths between the posterior and anterior midsagittal areas.
Orly Wiesel: Commentary on: Linear- Versus Circular-Stapled Esophagojejunostomy During Total Gastrectomy: Systematic Review and Meta-Analysis by Sozzi et al (J Laparoendosc Adv Surg Tech A . )
In their well-designed meta-analysis, Sozzi et al. are trying to end a long-lasting well-known surgical debate1 and to determine the best method for a stapled esophagojejunostomy...
Response to Eglash re: "The Risk of Breakthrough Bleeding Justifies the Use of Combined Hormonal Contraception Over Progesterone-Only Pills While Breastfeeding": Combined Hormonal Contraception Is Not Without Disadvantages, But Is Acceptable During Lactat
Full title: Lior Segev , Abraham O Samson: Response to Eglash re: "The Risk of Breakthrough Bleeding Justifies the Use of Combined Hormonal Contraception Over Progesterone-Only Pills While Breastfeeding": Combined Hormonal Contraception Is Not Without Disadvantages, But Is Acceptable During Lactation (Breastfeed Med
.)Ali Tarabeih, Doua Bakry, Elena Bukovetzky, Orna D. Gottfried: Testing the Double Cause Hypothesis for Autoimmune Diseases, Dipalmitoylphosphatidylcholine Should be Measured in Plasma or Blood Vessels of Diabetes Type 1? (Medical Research Archives)
The lung surfactant dipalmitoylphosphatidylcholine (DPPC) leaks into the blood, settling on the luminal aspect of blood vessels to create active hydrophobic spots. Nanobubbles are formed at these spots from dissolved gas. We hypothesized that when a large molecule in the blood comes into contact with a nanobubble at the active hydrophobic spots, its tertiary structure is disrupted.
Aviv Vidan: The Prevalence of Amblyopia and Eye Diseases among Pediatric Jewish Ethiopian Immigrants in Israel: An Observational Cross-sectional Study (Isr Med Assoc J .)
In developed countries, amblyopia has an estimated prevalence rate of 1-4%, depending on the socioeconomic gradient. Previous studies performed on pediatric populations in Ethiopia demonstrated amblyopia rates up to 16.7. Objectives: To assess rates of amblyopia, refractive errors, strabismus, and other eye pathologies among Ethiopian-born children and adolescents who immigrated to Israel compared to Israeli-born children.
Chen Hanna Ryder, Yair Shmidt, Naomi Dovrat, Ziv Sarusi, Noam Welder-Segalovich, Matan Segalovich, Daniel Marmor, Radi Shahien: The Relationship Between Immune and Inflammatory Markers and Short-term Clinical Outcomes after Stroke: Side Matters (Isr Med A
The two cerebral hemispheres influence the immune response differently. While the left hemisphere enhances cellular immunity, the right hemisphere inhibits it. Objectives: To determine whether immune and inflammatory markers correlated with stroke severity and hospitalization duration as a function of stroke side.
Yishai Mintzker: Mild Hyponatremia as an Early Marker for Intrathoracic Cancer: A Cohort Study (Isr Med Assoc J . )
Intrathoracic cancer can cause hyponatremia, but it is uncertain whether mild hyponatremia in the outpatient setting should be regarded as an early sign of intrathoracic cancer. Objectives: To evaluate the risk of undiagnosed intrathoracic cancer in patients with new persistent mild hyponatremia.
Ala Aiob, Haddad Yousef, Raneen Abu Shqara, Susana Mustafa Mikhail, Marwan Odeh, Lior Lowenstein: Risk factors and prediction of ectopic pregnancy rupture following methotrexate treatment: A retrospective cohort study (Eur J Obstet Gynecol Reprod Biol .)
Ectopic pregnancy (EP) rupture after methotrexate (MTX) treatment can have severe consequences. We examined clinical characteristics and beta-hCG trends that may predict EP rupture after MTX treatment.
Tawfik Khoury: Treatment of esophagogastric junction outflow obstruction with concomitant hypercontractile esophagus: A case series (Indian J Gastroenterol . )
Hypercontractile esophagus with concomitant esophagogastric junction outflow obstruction (EGJOO) is a rare entity that is characterized by both esophageal hypercontractility and lack of relaxation of the EGJ. The clinical characteristics of these patients are not well-described and there is no strict recommendation regarding the treatment of this condition. We report four cases of patients with hypercontractile esophagus and concomitant to EGJOO.
Avishalom Sharon, Muhammad Zidane, Ala Aiob, Liat Apel-Sarid, Jacob Bornstein: Nonelectric shaving of endometrial polyp by hysteroscopy - A new technique to eliminate thermal damage (Eur J Obstet Gynecol Reprod Biol .)
To present a new technique for complete endometrial polypectomy, using the bipolar loop hysteroscope, but without the activation of electrical energy, and follow its efficiency and safety for the patient.
Avinoam A Nachshon, Raed Salim: Impact of COVID-19 mandatory lockdown on maternal gestational weight gain and neonatal macrosomia rate at an academic medical center in Israel (J Matern Fetal Neonatal Med .)
In an effort to prevent the spread of coronavirus disease 2019 (COVID-19), governments restricted outdoor activities and imposed lockdown quarantine. This change in lifestyle probably affected individuals' eating habits and physical activity. Objective: To examine the effect of lockdown due to the COVID-19 pandemic on maternal antenatal weight gain, neonatal macrosomia, and other maternal and neonatal outcomes of women delivering at an academic medical center in Israel.
Ory Wiesel: The Whiteboard Time Out: A Novel Tool to Improve Resident Learning in the Operating Room (J Surg Educ . )
"Flipping the classroom" is a strategy that has been implemented in various educational environments to create a student-centered learning environment. Within this model of teaching, "first exposure" occurs prior to the classroom in a lower form of cognitive demand, allowing students to employ higher forms of cognition within the classroom. Surgical education has evolved over recent years to incorporate different modalities of learning; however, optimal educational approaches within the operating room (OR) have not been clearly defined. The Whiteboard Time Out (WBTO) utilizes the idea of "flipping the classroom" to make learning within the OR more resident centered. Residents complete most of the preoperative work prior to the case with a focus on the indications, steps of the procedure, and potential complications associated with the procedure. Residents then utilize a whiteboard located in the OR to outline, diagram, and discuss this information with the attending. Aims of the study are to enhance higher level intraoperative resident learning and attending teaching and improve resident knowledge and the ability to communicate surgical steps.
Sivan Spitzer: The COVID-19 Israeli tapestry: the intersectionality health equity challenge (Isr J Health Policy Res .)
COVID-19 is disproportionately affecting disadvantaged populations, with greater representation and worse outcomes in low socioeconomic and minority populations, and in persons from marginalized groups. General health care system approaches to inequity reduction (i.e., the minimization of differences in health and health care which are considered unfair or unjust), address the major social determinants of health, such as low income, ethnic affiliation or remote place of residents. Yet, to effectively reduce inequity there is a need for a multifactorial consideration of the aspects that intersect and generate significant barriers to effective care that can address the unique situations that people face due to their gender, ethnicity and socioeconomic situation.
Amir Mari: Non-alcoholic fatty pancreas disease and pancreatic exocrine insufficiency: pilot study and systematic review (Scand J Gastroenterol .)
The prevalence of non-alcoholic fatty pancreas disease (NAFPD) is estimated as 2-46% among patients without known pancreatic diseases. An association between NAFPD and non-alcoholic fatty liver disease (NAFLD) has been proposed, as well as an association between NAFPD and pancreatic exocrine insufficiency (PEI).