חדשות המחקר

Protein Kinase A (PKA) neuronal function is controlled by the interaction of a regulatory (R) subunit dimer to two catalytic (C) subunits. Recently, the L50R variant in the gene encoding the RIβ subunit was identified in individuals with a novel neurodegenerative disease. However, the mechanisms driving the disease phenotype remained unknown. In this study, we generated a mouse model carrying the RIβ-L50R mutation to replicate the human disease phenotype and study its progression with age. 

(Tal Benjamin-Zukerman, Gilat Shimon, Anwar Dakwar, Netta Peled, Mohammad Aboraya, Ashar Masri-Ismail, Rania Safadi-Safa, Meir Solomon, Ronit Ilouz)

Dilatation of common bile duct (CBD) is mostly pathological and mainly occurs secondary to mechanical causes. We aimed to explore the prevalence of CBD dilatation in Intraductal Papillary Mucinous Neoplasms of the pancreas (IPMN) among patients referred to EUS.

research letter

Heterotopic pregnancy of an intrauterine pregnancy and an interstitial or stump pregnancy after bilateral salpingectomy is a rare complication of in vitro fertilization (IVF) that can lead to severe hemorrhage; prompt identification and management are important. The aim of this paper was to present a case report and an updated literature review of women who had had combined interstitial/stump and intrauterine pregnancies during an in an IVF cycle after total bilateral salpingectomy.

No robust data are available on the safety of primary bariatric and metabolic surgery (BMS) alone compared to primary BMS combined with other procedures. The objective of this study is to collect a 30-day mortality and morbidity of primary BMS combined with cholecystectomy, ventral hernia repair, or hiatal hernia repair.

The carcinogenicity of air pollution and its impact on the risk of lung cancer is well known; however, there are still knowledge gaps and mixed results for other sites of cancer.

Iodinated Contrast Media (ICM) is used daily in many imaging departments worldwide. The main risk associated with ICM is hypersensitivity. When a severe hypersensitivity reaction is not properly managed and treated swiftly, it may be fatal. Currently, there is no data to demonstrate how ICM sensitivity affects the prognosis of cardiac patients, especially those diagnosed with ST elevation myocardial infarction (STEMI), in whom urgent coronary angiography is indicated. This study aimed to identify and characterize this relationship. 

Intrapartum fever (>38°C) is associated with adverse maternal and neonatal outcomes. However, the correlation between low-grade fever (37.5-37.9°C) and adverse perinatal outcomes is controversial. Objective: To compare maternal and neonatal outcomes of women with prolonged rupture of membranes (ROM) (>12h) at term, between those with low-grade fever and those with normal body temperature.

It would be a challenge to place this paper into one specific category; it encompasses a lot for one article, by providing a glimpse into a variety of topics, all interconnected but diverse. Even having a quite large supplemental material still requires from a reader—who might be a bioengineer or biochemistry major—to dig into the carbon dots (CDs) and RNA methylomics, and from a clinical scientist—to refresh their molecular knowledge (and insight into the herbal medicine!). We consider this to be a plus for any scientific publication to both enlighten the reader in the new findings as well as to make them wish to learn/read more. What is certain, this report is a must-read for a bone-centered biologist. Here we review this demanding article having mostly this type of audience in mind.

A knowledge gap exists regarding the association between vitiligo and rheumatoid arthritis (RA) due to the absence of large-scale cohort studies designed to investigate this association. To investigate the bidirectional epidemiological association between vitiligo and RA. A population-based study was conducted using Clalit Health Services (CHS) database (2002-2019) using both a cohort study and a case-control study design. 

Laparoscopic gastric plication (LPG) is a restrictive procedure to reduce the size of the stomach by folding and suturing the stomach to decrease its capacity. LGP has a high revision rate, mostly to sleeve gastrectomy. To the best of our knowledge, this is the first such report on the bariatric population that has been never described before.The purpose of this video was to show the feasibility and safety, as well as the main technical aspects, of a laparoscopic conversion of gastric plication to One Anastomosis Gastric Bypass.

Therapies targeting the PD-1/PD-L1 pathway have transformed head and neck squamous cell carcinoma (HNSCC) treatment. However, predicting the response to anti-PD-1 therapy remains a clinical challenge. This study evaluated the functional binding of PD-1 ligands in 29 HNSCC patients and compared it to the standard PD-L1 Combined Positive Score (CPS). The assessment of PD-1 ligands' functionality advances the current ability to predict the response of HNSCC patients to anti-PD-1 therapy.

Osteoporotic vertebral compression fractures (VCFs) are prevalent among the elderly population, and Balloon kyphoplasty (BKP) is a minimally invasive solution for these. However, Polymethylmethacrylate (PMMA) leakage is a significant complication with potentially severe consequences. This study compares the safety and efficacy of manual balloon tamp system (MTS) and hydraulic Polymethylmethacrylate pressure delivery system (HPDS) in BKP.

Editorial

With the advancement in modern medicine and improved patient care, clinicians are required nowadays to assess more patients in their 80’s and 90’s. when these patients are being considered for surgery—current research emphasizes that physiological age is more important than chronologic age during patient assessment for surgery.

Dear Editor,

Pemphigoid gestationis (PG) is a rare autoimmune blistering disease. It affects pregnant or postpartum women and presents with pruritus and blistering skin lesions. Adverse pregnancy outcomes (APOs)  in PG patients pose a potential threat to mother and foetus. So far, data from small cohort studies suggested an increased risk for preterm labor and fetal growth restriction in PG patients1-5. Yet, the risk of APOs has, so far not been contrasted among PG- and non-PG pregnancies and data from large cohort studies exploring these and other APOs are missing (Table S1).  To address this clinically important knowledge gap we here aimed to determine the risk of APOs in PG patients and controls.