חדשות המחקר

Proper nasal tip projection and rotation have a strong impact on nasal aesthetics. Septal extension graft is one of the tools used to improve tip projection and rotation when performing rhinoplasty. This graft typically overlaps the existing caudal septum in the midline position, lengthening it and facilitating the repositioning of the tip. Describes the technical evolution of the septal extension graft in endonasal rhinoplasty and evaluate the reliability and long-term efficacy of the current technique.

In clinical trials with hepatitis C virus-infected treatment-naïve (TN) patients with compensated cirrhosis (CC), glecaprevir/pibrentasvir (G/P), a fixed-dose, once-daily, pangenotypic regimen, has demonstrated sustained virologic response at posttreatment Week 12 (SVR12) > 95%. We evaluated the real-world safety and effectiveness of 8-week G/P therapy in TN patients with CC, including certain subgroups of interest.

The training of near-peer (NP) teachers and junior faculty instructors received major attention as a possible solution for the shortage of experienced anatomy instructors in faculties of medicine and health professions. Several studies described the training of NP teachers and junior instructors (≤ 2 years of teaching experience) using various methods. However, few publications include On the Job Training (OJT), which enables reflection and performance evaluation and encourages professionals to cope with their blind spots. Previous publications describing OJT did not include formal observation of the NP teacher or junior instructor. Therefore, this study aimed to present a novel approach to OJT inclusion during prosection laboratories based on the Lewinian experiential model.

During advanced HIV infection, Human Cytomegalovirus (HCMV) has been proven to produce devitalizing end-organ diseases (EOD). The interactive co-existence of HIV and HCMV has been reported by many researchers and has been suggested to be linked with a more aggressive disease state. This study has been designed to bring forward an assessment of the clinical risk factors capable of defining the conditions of HCMV induced retinitis and gastro-enteric diseases among HIV1 seropositive patients.

Epidemiological evidence regarding the course and activity patterns of hidradenitis suppurativa (HS) is yet to be delineated. Identifies activity patterns of HS throughout the time axis and to outline predictors of recalcitrant disease course.

Assesses the biofilm-producing capacities of S. aureus strains isolated from hospitalized patients in Israel.

Letter

(No abstract available)

Membrane computing or P-systems is a subfield of natural computing, which models living systems with mathematical tools. In classical membrane-computing, cells or organs are surrounded by a simple membrane and computational events take place in either side of the membrane. We have developed a new conceptual tool to better fit P-systems to higher-order organisms, which rely on the actual membrane structure of the cell and on the biochemical reactions (rules), which take place on the membrane of different organs in our body. To demonstrate the power of this new concept, we modeled the process of maintaining normoglycemia in healthy individuals as well as in type-I and type-II diabetes patients. The main challenge was to prioritize the insulin-producing β-cells over other organs, i.e., once glucose has entered the body, it must first enter specifically into pancreatic β-cells in order to release the hormone Insulin. However, using classical membrane computing, we could not implement this hierarchy. Therefore, we chose to utilize the membrane actual physiology and add its properties to the current definitions of membrane computing. In particular, we use enzymes and protein-transporters (as well as channels) to apply algebraic rules. In addition, we show that the defined systems are universal, by simulating register machines. Thus, allowing deterministic manner operations in a non-deterministic system by giving membrane-specific rules. To our gratification, we succeeded to adequately describe the process of glucose homeostasis in health and disease while bringing the science of membrane-computing closer to the natural world.

Deep sternal wound infection (DSWI) is one of the most complex and devastating complications post cardiac surgery. We present here the modified sternoplasty, a novel surgical technique for treating DSWI post cardiac surgery. 

Preeclampsia is a multisystem disorder and the leading cause of severe morbidity and death in pregnancy. Liver involvement in preeclampsia ranges from elevated liver enzyme levels to hepatic infarction or rupture. Endothelial dysfunction leads to changes in blood flow and congestion and may be involved in the pathophysiology of preeclampsia. Changes in splanchnic blood flow and portal congestion can result in altered liver stiffness. Transient elastography is a non-invasive ultrasound-based technique that measures organ stiffness as well as steatosis, therefore widely used in clinical hepatology. Previous studies reported elevated liver stiffness and liver steatosis, as measured by transient elastography, in women with preeclampsia. This study followed changes in liver stiffness and steatosis, as measured by transient elastography, from the antepartum period to one-week postpartum among women with preeclampsia versus healthy controls; and evaluated the association of preeclampsia severity with transient elastography results.

Pathophysiology of type 1 diabetes (T1D) involves immune responses that may be associated with early exposure to environmental factors among preterm newborns. The aim of this work was to evaluate for association between T1D and maternal, nutritional, and medical exposures during the neonatal period among premature newborns.

Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours.

The association between Body Mass Index (BMI) and clinical outcomes following acute heart failure (AHF) hospitalization is debated in the literature. Our objective was to study the real-world relationship between BMI and in-hospital mortality in patients who were admitted with AHF.

Risk stratification in acute myocarditis is based on the clinical signs of heart failure, the degree of cardiac dysfunction, and the findings in cardiac magnetic resonance (CMR). The aim of the current study is to examine the prognostic yield of the natriuretic peptide N-terminal-pro hormone Brain Natriuretic Peptide (NT-proBNP) and C-reactive protein (CRP) in acute myocarditis among patients with preserved/mildly reduced left ventricular ejection fraction (LVEF).