חדשות המחקר
Eric Shinwell, Bella Lurye-Marcu: The Yield of Targeted Examination for the Detection of Symptomatic Congenital Cytomegalovirus Infection (Isr Med Assoc J .)
The incidence of congenital cytomegalovirus (CMV) infection in Israel is 0.7%. Only 10-15% are symptomatic. Valganciclovir has been shown to improve hearing and neurodevelopmental outcomes in neonates with symptomatic congenital CMV infection. Targeted examination of infants who fail routine neonatal hearing screening or have clinical or laboratory findings suggestive of symptomatic congenital CMV infection may be a cost-effective approach.
Albert Gorski, Marwa Nahas, Lior Feintuch, Nimrod Rahamimov: Treatment of Peripheral Nerve Injuries in Syria's War Victims: Experience from a Northern Israeli Hospital (Isr Med Assoc J)
The collapse of the Syrian healthcare system during the civil war led numerous citizens to cross the Syrian-Israeli border to seek medical care. Describes the epidemiology of peripheral nerve injuries (PNIs) sustained in war, their management, and short-term outcomes.
Tomer Meirson: Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy (J Immunother Cancer . )
Adoptive cell therapy with T cells genetically engineered to express a chimeric antigen receptor (CAR-T) or tumor-infiltrating T lymphocytes (TIL) demonstrates impressive clinical results in patients with cancer. Lymphodepleting preconditioning prior to cell infusion is an integral part of all adoptive T cell therapies. However, to date, there is no standardization and no data comparing different non-myeloablative (NMA) regimens.
Menachem Alcalay: A dynamic prediction score for obstetric anal sphincter injury among nulliparous women delivering vaginally (Int J Gynaecol Obstet .)
Develops a risk score for obstetric anal sphincter injury (OASI) occurrence among nulliparous women delivering vaginally, based on data available at admission for delivery and as labor progresses.
Mohammad E Naffaa: Immune-Mediated Disease Flares or New-Onset Disease in 27 Subjects Following mRNA/DNA SARS-CoV-2 Vaccination (Vaccines (Basel) . )
Infectious diseases and vaccines can occasionally cause new-onset or flare of immune-mediated diseases (IMDs). The adjuvanticity of the available SARS-CoV-2 vaccines is based on either TLR-7/8 or TLR-9 agonism, which is distinct from previous vaccines and is a common pathogenic mechanism in IMDs.
We evaluated IMD flares or new disease onset within 28-days of SARS-CoV-2 vaccination at five large tertiary centres in countries with early vaccination adoption, three in Israel, one in UK, and one in USA. We assessed the pattern of disease expression in terms of autoimmune, autoinflammatory, or mixed disease phenotype and organ system affected. We also evaluated outcomes.
Wisam Sbeit, Anas Kadah, Matta Simaan, Amir Shahin, Tawfik Khoury: Predictors of recurrent bile duct stone after clearance by endoscopic retrograde cholangiopancreatography: A case-control study (Hepatobiliary Pancreat Dis Int .)
Recurrent common bile duct (CBD) stone are a long-term sequalae among patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) with CBD stone extraction. Data regarding risk factors for recurrent CBD stone are scarce. We aimed to identify predictors of recurrent CBD stone.
Michal Tietel, Lilach Shema-Didi, Ruti Roth, Maya Frank Wolf, Jacob Bornstein: Compliance with a new quality standard regarding administration of prophylactic antibiotics before cesarean section J Matern Fetal Neonatal Med .)
Administering prophylactic antibiotics before cesarean section (CS) decreases postpartum infections significantly. They should be administered within 60 min prior to CS. In 2014 the Israeli Ministry of Health introduced the administration of pre-operative antibiotic prophylaxis for CS as a quality criterion. This was immediately adopted by the Galilee Medical Center (GMC). This study aimed to examine the compliance to this quality standard in the GMC under 3 criteria: the type of antibiotics, timing of administration, and use of one dose only.
Khalaf Kridin: Coexistence of bullous pemphigoid with neuropsychiatric comorbidities is associated with anti-BP230 seropositivity (J Eur Acad Dermatol Venereol .)
While clustering of bullous pemphigoid (BP) with neuropsychiatric diseases is well-established, the clinical and immunological profile of BP patients with this comorbidity remains to be decisively determined. Evaluates the burden of neurological and psychiatric comorbidities among patients with BP and to elucidate the clinical, immunological, and immunopathological features of patients with BP and comorbid neuropsychiatric conditions.
Fahed Hakim: Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation (Immunity .)
The sympathetic nervous system is composed of an endocrine arm, regulating blood adrenaline and noradrenaline, and a local arm, a network of fibers innervating immune organs. Here, we investigated the impact of the local arm of the SNS in an inflammatory response in the colon.
Adnan Zaina: COVID-19 Pandemic and Ramadan Fasting among Patients with Type 2 Diabetes Mellitus (Isr Med Assoc J . )
This year Ramadan occurs during the global coronavirus disease-2019 (COVID-19) pandemic. Data has shown that patients with type 2 diabetes mellitus (T2DM) are prone to severe disease with COVID-19 and with increased mortality. Acute complications such as dehydration, starvation ketosis, ketoacidosis, and the increased risk of coagulopathy and thrombosis should be considered particularly during this pandemic period. Fasting during Ramadan this year and the COVID-19 pandemic is more challenging, not only for patients with T2DM but also for healthcare providers. We present healthcare providers with important aspects to consider during the COVID-19 pandemic for patients with T2DM who intend to fast during Ramadan and other fasting days.
