Recent Publications
Taer Abu Jabal, Magid Ganayem, Avi Peretz, Orna Nitzan: The Undesired Outcomes of Bodybuilding: An Intra-Deltoid Abscess Caused by Eikenella corrodens After Licking the Needle (Isr Med Assoc J .)
We describe, to the best of our knowledge, the first case of a body builder with an intradeltoid abscess due to , probably because he licked the needle to clean it prior to injection of steroids. This report highlights the potential harms of illegally used muscle-building products and of incorrect and non-sterile injection techniques with potential infectious complications and muscle damage.
Naama Garmi, Suheil Nasrallah, Yacov Baram, Adina Katz, Avishai Koren, Maya First, Arnon Blum: Platelets and Breast Cancer (Isr Med Assoc J .)
To investigate whether pre-treatment platelet counts correlated with clinical outcomes of patients with breast cancer
Shira Ben-Simon, Lital Ozeri, Omry Koren: In utero human intestine harbors unique metabolomic features including bacterial metabolites (JCI Insight .)
Symbiotic microbial colonization through the establishment of the intestinal microbiome is critical to many intestinal functions including nutrient metabolism, intestinal barrier integrity and immune regulation. Recent studies suggest that education of the intestinal immunity maybe ongoing in utero. However, the drivers of this process are unknown. The microbiome and its byproducts are one potential source. Whether a fetal intestinal microbiome exists is controversial and if microbially derived metabolites are present in utero is unknown. Here, we aimed to determine whether bacterial DNA and microbially-derived metabolites can be detected in second trimester human intestinal samples.
Marwan Odeh, Rawan Karwani, Oleg Schnaider, Maya Wolf, Jacob Bornstein: Dehiscence of cesarean section scar during pregnancy and delivery - risk factors (Ginekol Pol . )
Identifies risk factors for dehiscence of cesarean section (CS) scars in patients undergoing repeated cesarean section.
Shahar Perlmutter: Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in Cancer (Cancers (Basel) . )
Glycosylation patterns commonly change in cancer, resulting in expression of tumor-associated carbohydrate antigens (TACA). While promising, currently available anti-glycan antibodies are not useful for clinical cancer therapy. Here, we show that potent anti-glycan antibodies can be engineered to acquire cancer therapeutic efficacy.
David Karasik: Genetic basis of falling risk susceptibility in the UK Biobank Study (Commun Biol .)
oth extrinsic and intrinsic factors predispose older people to fall. We performed a genome-wide association analysis to investigate how much of an individual's fall susceptibility can be attributed to genetics in 89,076 cases and 362,103 controls from the UK Biobank Study.
Menachem Alcalay: The association between vacuum-assisted vaginal delivery and anal sphincter injury (Int Urogynecol J .)
Vacuum-assisted vaginal delivery (VAVD) is considered a major risk factor for obstetric anal sphincter injuries (OASIS). However, it is difficult to estimate its true contribution to the occurrence of OASIS, as its performance may be confounded by other determinants. Therefore, we aimed to evaluate the association of VAVD with OASIS among primiparous women compared to SVD.
Sumit Mukherjee: Insight into the distinctive paradigm of Human Cytomegalovirus associated intrahepatic and extrahepatic cholestasis in neonates (Sci Rep)
Human Cytomegalovirus has been implicated as a probable cause for the development of hepatic cholestasis among neonates. Our study tried to ascertain the exact demographic, biochemical and immunological markers to differentially diagnose patients with HCMV associated intrahepatic and extrahepatic cholestasis and also decipher the phylogenetic variability among the viral strains infecting the two groups.
Gon Carmi, Somnath Tagore, Alessandro Gorohovski, Aviad Sivan, Dorith Raviv-Shay, Milana Frenkel-Morgenstern: Design principles of gene evolution for niche adaptation through changes in protein-protein interaction networks (Sci Rep .)
In contrast to fossorial and above-ground organisms, subterranean species have adapted to the extreme stresses of living underground. We analyzed the predicted protein-protein interactions (PPIs) of all gene products, including those of stress-response genes, among nine subterranean, ten fossorial, and 13 aboveground species.
Eric S Shinwell: Newborn care during the COVID-19 pandemic must adapt as evidence accumulates (Acta Paediatr . )
Editorial: The COVID‐19 pandemic is an ongoing learning experience for the healthcare professions and the world at large. A sense of profound humility emerges from mankind's limited success in developing and implementing consensus‐based guidelines for the control and treatment of this frightening disease. Specifically, the care of infants born to women with suspected or proven COVID‐19 infection raises challenges that call into question established and evidence‐based policies and treatments. As new evidence becomes available, individual caregivers and professional organisations are required to re‐assess potentially best practices that are appropriate in each setting.
Menachem Alcalay, Moshe Ben Ami, Anatoly Greenshpun: Fractional-Pixel CO 2 Laser Treatment in Patients With Urodynamic Stress Urinary Incontinence: 1-Year Follow-Up (Lasers Surg Med .)
Vaginal pixelated low power and long pulses (LPLP) CO2 laser has been suggested as an optional treatment for stress urinary incontinence (SUI) with many studies reporting short-term improvements. The objective of this study was to assess the 1-year subjective and objective efficacy of vaginal CO2 laser in women with urodynamic SUI.
Baruh Polis, Abraham O Samson: Neurogenesis versus neurodegeneration: the broken balance in Alzheimer's disease (Neural Regen Res . )
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, eventually manifesting in severe cognitive dysfunction. Despite the recent proliferation of encouraging preclinical studies and clinical trials, scientific society is still far from a complete consensus regarding the AD etiology and pathogenesis. Accordingly, no approved AD-modifying therapies are currently available. Nevertheless, novel concepts predicated upon the latest discoveries and comprehension of the disease as a multifactorial disorder are paving the road to the successful AD treatment.
Tomer Meirson: Cardiovascular adverse events associated with hydroxychloroquine and chloroquine: A comprehensive pharmacovigilance analysis of pre-COVID-19 reports (Br J Clin Pharmacol .)
There is a clinical need for safety data regarding hydroxychloroquine (HCQ) and chloroquine (CQ) during the coronavirus (COVID-19) pandemic. We analysed real-world data using the U.S. Food and Drug Administration Adverse Events Reporting System (FAERS) database to assess HCQ/CQ-associated cardiovascular adverse events (CVAEs) in pre-COVID-19 reports.
Ibrahim Marai, Nizar Andria, Liza Grosman-Rimon, Evgeni Hazanov, Wadi Kinany, Diab Ghanim, Offer Amir, Shemy Carasso: Clinical and echocardiographic characteristics of patients with preserved versus mid-range ejection fraction (Int J Cardiovasc Imaging .)
A wide range of ejection fraction (EF) thresholds have been used to categorize patients with heart failure (HF) with "preserved" EF. Our goal was to characterize the clinical and echocardiographic differences among patients with cardiac structural/functional alterations and mid-range EF (mrEF) (EF 40-49%) compared to preserved EF (pEF) (EF ≥ 50%), irrespective of HF.