Recent Publications
Celia Suru: Daratumumab for relapsed AL amyloidosis - when cumulative real-world data precedes clinical trials: A multisite study and systematic literature review (Eur J Haematol .)
Patients with relapsed/refractory AL amyloidosis (RRAL) have poor prognosis, but emerging data shows promising results with the use daratumumab. We evaluated daratumumab treatment in RRAL in real-world setting.
Inbar Ben Shachar, Ilan Atlas: Increased ultrasonographic endometrial thickness is associated with poor survival in patients with endometrial cancer: An Israel gynecologic oncology group study (Eur J Surg Oncol . )
We aimed to assess the association of pre-operatively evaluated ultrasonographic endometrial thickness with outcomes of patients with endometrial cancer.
Enav Yefet: One elevated oral glucose tolerance test value in pregnancy increases the risk for future diabetes mellitus type 2 (Arch Gynecol Obstet . )
Women with only one elevated 100 g OGTT value are not considered as having gestational diabetes mellitus (GDM) and therefore there are no recommendations to address this population as a risk group for type 2 diabetes mellitus (T2DM). We aimed to elucidate whether one elevated OGTT value increases the risk for T2DM.
Yana Lerner, Wessal Hanout, Shulamit Fluss Ben-Uliel, Samar Gani, Michal Pellach Leshem, Nir Qvit: Natriuretic peptides as the basis of peptide drug discovery for cardiovascular diseases (Curr Top Med Chem .)
This article will review the current knowledge about peptides and their role in the circulatory system, focusing on the physiological roles of natriuretic peptides in the cardiovascular system and their implications in CVDs
Dana Binyamin, Nir Werbner, Meital Nuriel-Ohayon, Atara Uzan, Hadar Mor, Oren Ziv, Omry Koren:The aging mouse microbiome has obesogenic characteristics (Genome Med . )
During aging, there is a physiological decline, an increase of morbidity and mortality, and a natural change in the gut microbiome. In this study, we investigated the influence of the gut microbiome on different metabolic parameters in adult and aged mice.
Maya Frank Wolf, Rosa Michlin, Yaniv Farajun, Ella Ophir, Jacob Bornstein: Intrauterine bacterial growth in elective and non-elective caesarean sections (J Obstet Gynaecol . )
We assessed intrauterine bacterial growth for elective and non-elective caesarean sections (CSs).
Sarina Harshuk-Shabso, Hila Dressle, Emil Aamar, David Enshell-Seijffers: Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock (Nat Commun .)
Tissue growth in the adult is an orchestrated process that often requires biological clocks to time stem cell and progenitor activity. Here, we employed the hair follicle, which cycles between growth and regression in a timely-restricted mode, to show that some components of the hair cycle clock reside within the mesenchymal niche of the hair follicle, the dermal papilla (DP), and both Fgf and Wnt signaling pathways interact within the DP to regulate the expression of these components that include Wnt agonists (Rspondins) and antagonists (Dkk2 and Notum).
Inbar Ben-Shachar, Ilan Atlas: Age is an independent predictor of outcome in endometrial cancer patients: an Israeli Gynecology Oncology Group cohort study (Acta Obstet Gynecol Scand .)
Advanced age is considered an adverse factor in endometrial cancers, but may be a surrogate for other conditions that impact outcomes. The study objective was to assess the association of age with endometrial cancer features, treatment and prognosis.
Zaher Armaly, Karl Skorecki: ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the Puzzle (Front Physiol .)
Engulfed by the grave consequences of the coronavirus disease 2019 (COVID-19) pandemic, a better understanding of the unique pattern of viral invasion and virulence is of utmost importance....This highlights the importance of focusing on ACE2 physiology in the evaluation and management of COVID-19 disease.
Chaim Putterman: Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity (Immun Ageing . )
The immune system undergoes a myriad of changes with age. While it is known that antibody-secreting plasma and long-lived memory B cells change with age, it remains unclear how the binding profile of the circulating antibody repertoire is impacted.
Yumna Busool Abu-Eta: Outcomes of photorefractive keratectomy in patients with posterior corneal steepening (Eye (Lond) . )
Assesses post-operative outcomes following photorefractive keratectomy (PRK) in patients with posterior corneal steepening compared to an age, gender and refraction matched control group.
Yoav Bahat, Joel Alter, Moshe Dessau: Crystal structure of tomato spotted wilt virus G N reveals a dimer complex formation and evolutionary link to animal-infecting viruses (Proc Natl Acad Sci U S A .)
Tospoviridae is a family of enveloped RNA plant viruses that infect many field crops, inflicting a heavy global economic burden. These tripartite, single-stranded, negative-sense RNA viruses are transmitted from plant to plant by thrips as the insect vector. The medium (M) segment of the viral genome encodes two envelope glycoproteins, GN and GC, which together form the envelope spikes. GC is considered the virus fusogen, while the accompanying GN protein serves as an attachment protein that binds to a yet unknown receptor, mediating the virus acquisition by the thrips carrier. Here we present the crystal structure of glycoprotein N (GN) from the tomato spotted wilt virus (TSWV), a representative member of the Tospoviridae family.
Adi Eshel, Omry Koren: Alterations in the Intestinal Morphology, Gut Microbiota, and Trace Mineral Status Following Intra-Amniotic Administration ( Gallus gallus) of Teff ( Eragrostis tef) Seed Extracts (Nutrients . )
The consumption of teff (Eragrostis tef), a gluten-free cereal grain, has increased due to its dense nutrient composition including complex carbohydrates, unsaturated fatty acids, trace minerals (especially Fe), and phytochemicals. This study utilized the clinically-validated Gallus gallus intra amniotic feeding model to assess the effects of intra-amniotic administration of teff extracts versus controls using seven groups: (1) non-injected; (2) 18Ω H2O injected; (3) 5% inulin; (4) teff extract 1%; (5) teff extract 2.5%; (6) teff extract 5%; and (7) teff extract 7.5%.
Tomer Meirson: Survival-Inferred Fragility Index of Phase 3 Clinical Trials Evaluating Immune Checkpoint Inhibitors (JAMA Netw Open .)
Calculates the fragility of survival data in randomized clinical trials (RCTs) evaluating immune checkpoint inhibitors (ICIs).
Rina Dolinski, Luiza Akria, Yevgeni Yampoulski, Jamal Awad: A Case of Hemophagocytic Lymphohistiocytosis Associated With Mediterranean Spotted Fever in a Healthy 29-Year-Old Female (Open Forum Infect Dis .)
A 29-year-old female presented with fever, headache, and epigastric pain. Though her initial presentation was benign and nonspecific, she soon developed a full-blown cytokine storm with disseminated intravascular coagulation. She was diagnosed with hemophagocytosis secondary to Rickettsia conorii infection. A good outcome was achieved thanks to prompt diagnosis and proper treatment.