Recent Publications
Tal Shachar: Is Time a Factor in Quality of Life Improvement Following Breast Reduction (Aesthet Surg J .)
Macromastia (breast hypertrophy) has significant influence on patients' quality of life (QoL), therefore surgical treatment has a clear medical benefit. Rapid improvements in musculoskeletal complaints are being reported long before when final aesthetic results are traditionally evaluated. The study aim is to use the RAND Health Status Survey, a modified validated short-form-36, to analyze patient QoL after breast reduction, and examine whether QoL changes as a function of time post operation.
Kamal Hamoud: Spinous Process Inclination in Degenerative Lumbar Spinal Stenosis Individuals (Biomed Res Int . )
The aim of this study is to determine the sagittal inclination of lumbar spinous processes (SPs) in individuals with degenerative lumbar spinal stenosis (DLSS).
Avi Benov: Inclusion of extranodal extension in the lymph node classification of cutaneous squamous cell carcinoma of the head and neck (Cancer. )
The prognostic performance of the recently updated American Joint Committee on Cancer lymph node classification of cutaneous head and neck squamous cell carcinoma (HNSCC) has not been validated. The objective of this study was to assess the prognostic role of extranodal extension (ENE) in cutaneous HNSCC.
Najib Dally: Management and Outcome of Venous Thrombosis in Patients with Myeloproliferative Neoplasms: Data from the Israeli MPN Working Group (Acta Haematol .)
The BCR-ABL-negative myeloproliferative neoplasms (MPN) are associated with high incidence of venous thrombosis and a significant rate of recurrent events, but there is no consensus regarding their management. In this retrospective study, we analyzed 96 patients with MPN-related venous thrombosis.
Naamah Bloch, Shira Ben-Simon, Oren Ziv, Omry Koren: Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients (Science .)
The gut microbiome has been shown to influence the response of tumors to anti-PD-1 immunotherapy in pre-clinical mouse models and observational patient cohorts. However, modulation of gut microbiota in cancer patients has not been investigated in clinical trials. Here we performed a phase I clinical trial to assess the safety and feasibility of fecal microbiota transplantation (FMT) and re-induction of anti-PD-1 immunotherapy in ten patients with anti-PD-1-refractory metastatic melanoma.
Vered Fleischer-Sheffer: Evaluation of audio-voice guided application for neonatal resuscitation: a prospective, randomized, pilot study (J Perinat Med . )
Examines whether audio-voice guidance application improves adherence to resuscitation sequence and recommended time frames during neonatal resuscitation.
Enav Yefet, Abeer Suleiman: Hemoglobin drop following postpartum hemorrhage (Sci Rep . )
Postpartum hemorrhage (PPH) is defined as blood loss of ≥ 500-1000 ml within 24 h after delivery. Yet, assessment of blood loss is imprecise. The present study aimed to profile the hemoglobin (Hb) drop after vaginal delivery with versus without PPH.
Chaim Putterman: BTK inhibition modulates multiple immune cell populations involved in the pathogenesis of immune mediated nephritis (Clin Immunol .)
Lupus nephritis (LN) is a serious end organ complication of systemic lupus erythematosus. Nephrotoxic serum nephritis (NTN) is an inducible model of LN, which utilizes passive transfer of pre-formed nephrotoxic antibodies to initiate disease. In previous studies, we demonstrated that the Bruton's tyrosine kinase inhibitor, BI-BTK-1, prevents the development of nephritis in NTN when treatment was started prior to nephrotoxic serum transfer, and reverses established proteinuria as well....
David Karasik: The influence of adult hip shape genetic variants on adolescent hip shape: findings from a population-based DXA study (Bone . )
Hip shape is a well-recognized risk factor for hip osteoarthritis (OA) and hip fracture. We aimed to investigate whether the genetic variants known to be associated with adult hip shape were also associated with adolescent hip shape.
Lee S Izhaki-Tavor, Moshe Dessau: ATP-dependent RNA helicase domain of the ZC3H41 protein from Trypanosoma brucei: expression, purification and crystallization (Acta Crystallogr F Struct Biol Commun .)
A fragment of the Trypanosoma brucei ZC3H41 protein encompassing the ATP-dependent RNA helicase domain was successfully subcloned for expression in a bacterial system (Escherichia coli). Following expression, the protein was purified and crystallized using the vapor-diffusion method. The protein crystals were optimized at a 1:1 protein:reservoir solution ratio using PPGBA 2000. The optimized crystals diffracted to a dmin of 3.15 Å. The collected data revealed preliminary structural information regarding this newly discovered protein.
Maayan Gruber, Danny Damry, Nur Ibrahim, Daniel Glikman, Ohad Ronen: Pediatric acute otitis externa: Characteristics and predictors for hospital admission (Int J Pediatr Otorhinolaryngol . )
Acute otitis externa (AOE), is a common infectious disease affecting children and adults. Its peak prevalence is around the summer months, it involves the external auditory canal and in most cases is due to bacterial agents....This study highlights the main clinical variables which may predict hospitalization among children with AOE as well as the dominant role of sensitive strains of PA in the pathogenesis of this condition in children.
Enav Yefet, Abeer Suleiman: Relationship between patient ethnicity and prevalence of anemia during pregnancy and the puerperium period and compliance with healthcare recommendations - implications for targeted health policy (Isr J Health Policy Res)
Anemia is common during pregnancy and the puerperium. The association of ethnicity as well as other characteristics with anemia and compliance with healthcare recommendations has not been studied sufficiently and needs to be explored in order to implement a targeted health policy. We examined the association between ethnicity and the risk for prenatal and puerperium anemia and the compliance with healthcare recommendations. This effort aims to guide reforms in policies and practices that will assist in decreasing anemia prevalence in Israel.
Amir Mari, Tawfik Khoury, Mahmud Mahamid: The Yield of Ileoscopy: Does Indication Matter? (Isr Med Assoc J .)
While the routine performance of terminal ileum (TI) intubation during colonoscopy procedures is perceived to have a low yield, its utility during colonoscopies performed for specific indications have not been well studied. This study assesses the diagnostic yield of an indication-based ileoscopy in real-life practice.