Recent Publications
Avi Benov, Elon Glassberg: Prehospital Definitive Airway Is Not Associated With Improved Survival in Trauma Patients (J Trauma Acute Care Surg .)
The American College of Surgeons and the National Association of Emergency Medical Technicians advise securing a definitive airway if there is any doubt about the trauma patient's ability to maintain airway integrity. The objective of this study was to investigate the association between a success in securing a definitive airway in the prehospital setting and survival among trauma patients, in which the provider deemed a definitive airway was necessary.
Andrei Braester, Luiza Akria, Orly Yakir, Liron Shelev, Masad Barhoum: Blood Myths and Ethnic-Cultural Background as Impediments in Patient Blood Management Education (J Relig Health .)
A significant percentage of red blood cell transfusions (RBCTs) are the result of overuse. The implementation of patient blood management (PBM) is challenging. We examined whether blood-linked myths and ethnic-cultural background factors are impediments to PBM education and implementation.
Eli Kakiashvili: Robotic Inguinal Hernia Repair: Is It a New Era in the Management of Inguinal Hernias? (Asian J Surg .)
Compares outcomes of elective inguinal hernia repair performed at one institution by three approaches: robotic-assistance, laparoscopic, and open.
Rola Khamisy-Farah: Vaccines Are Underused in Pregnancy: What About Knowledge, Attitudes and Practices of Providers? (Acta Biomed .)
Investigates actual knowledge of official recommendations towards seasonal influenza (SID), and Tetanus-diphtheria acellular-pertussis (Tdap) vaccines in obstetrics/gynecologists (OBGYN).
Orna Dally-Gottfried:Birth During the Moderate Weather Seasons Is Associated With Early Onset of Type 1 Diabetes in the Mediterranean Area (Diabetes Metab Res Rev .)
Assesses the association of seasonal and perinatal parameters with early age of type 1 diabetes (T1D) onset.
Maayan Gruber: Developing Biodegradable Nanoparticles Loaded With Mometasone Furoate for Potential Nasal Drug Delivery (ACS Omega .)
Intranasal drug administration is considered a routine in the treatment of many nasal conditions including chronic rhinosinusitis (CRS), which is a common disease involving long-term inflammation of the nasal mucosa. Topical nasal steroid treatment is safe and easy to use and plays a basic role in both nonsurgical and surgical treatments for CRS. Intranasal steroid therapy for various time intervals is commonly used before and after endoscopic CRS nasal surgeries to reduce inflammation and edema and to improve mucosal healing. The medication is currently administered via conventional nasal sprays; therefore, there is an incentive to develop more efficient drug delivery systems for the controlled release of topical steroids into the sinonasal cavities over a prolonged period of time. In this study, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with mometasone furoate (MF) were generated using the nanoprecipitation method and characterized physicochemically and morphologically. MF NPs exhibited adequate physicochemical properties and high drug encapsulation efficiency and loading content. MF exhibited sustained release from NPs over 7 days in vitro with an initial burst release; various mathematical models were applied to determine the kinetics of drug release. Having demonstrated the ability to load MF in PLGA-NPs using the nanoprecipitation method for the first time, these NPs urge the need for additional investigations to demonstrate their therapeutic potential in nasal delivery applications.
Cardiac-peripheral transvenous gradients of microRNA expression in systolic heart failure patients. (ESC Heart Fail.)
The aims of the study are to assess the levels of coronary sinus (CS) miRNAs of systolic heart failure (HF) patients in samples obtained during cardiac resynchronization therapy (CRT) device implantation and compare them to the peripheral systemic venous miRNA expression. (Inbar Ben‐Zvi, Natalia Volinsky, Liza Grosman‐Rimon, Izhak Haviv, Guy Rozen, Nizar Andria, Nofar Asulin, Nufar Margalit, Ibrahim Marai, Offer Amir)
Abdulla Watad: Patients with psoriatic arthritis have higher levels of FeNO than those with only psoriasis, which may reflect a higher prevalence of a subclinical respiratory involvement. (Clin Rheumatol.)
Psoriatic arthritis (PsA) patients are often affected by numerous comorbidities. However, contrasting results have been reported with regard to the respiratory involvement in PsA patients. The aim of this study was to evaluate the presence of subclinical airway inflammation in non-smoking PsA patients compared to patients with only psoriasis using the fraction of exhaled nitric oxide (FeNO) as an indirect marker of airway inflammation.
Ron Eremenko, Nadia Lumelsky, Yoav Alkan: Urinary Tract Infection in Outpatient Children and Adolescents: Risk Analysis of Antimicrobial Resistance (Isr Med Assoc J . )
Describes resistance rates of urine bacteria isolated from children with UTI in the community settings. Identifies risk factors for resistance.
Rajashekar Donaka, David Karasik: Zebrafish Models of Sarcopenia (Dis Model Mech .)
Sarcopenia - the accelerated age-related loss of muscle mass and function - is an under-diagnosed condition, and is central to deteriorating mobility, disability and frailty in older age. There is a lack of treatment options for older adults at risk of sarcopenia. Although sarcopenia's pathogenesis is multifactorial, its major phenotypes - muscle mass and muscle strength - are highly heritable. Several genome-wide association studies of muscle-related traits were published recently, providing dozens of candidate genes, many with unknown function. Therefore, animal models are required not only to identify causal mechanisms, but also to clarify the underlying biology and translate this knowledge into new interventions. Over the past several decades, small teleost fishes had emerged as powerful systems for modeling the genetics of human diseases. Owing to their amenability to rapid genetic intervention and the large number of conserved genetic and physiological features, small teleosts - such as zebrafish, medaka and killifish - have become indispensable for skeletal muscle genomic studies. The goal of this Review is to summarize evidence supporting the utility of small fish models for accelerating our understanding of human skeletal muscle in health and disease.
Shachar Tal: Is family history of coronary artery disease important in the emergency department triage? (Int Emerg Nurs)
Explores the role of family history (FH) as a risk factor for ST elevation myocardial infarction (STEMI) in the emergency department (ED) setting during nurse triage and analyzes the clinical outcomes and time lags of patients with and without FH of coronary artery disease (CAD).
Y. Ghantous, MV Joachim, I. Abu-El-Na’aj: The Face of War: Maxillofacial Patients in the Syrian Civil War. (J Craniofac Surg)
The type of the armed conflict on the Syrian battle field acquired several types of injuries; including injuries that were caused by explosive, shrapnel and blast injuries.In the current study, the authors conducted an overview of maxillofacial patients, who mainly suffered from ballistic injuries in term of injuries, reconstruction, and management....To conclude, the Syrian civil war has several characteristics that defer from other combats. Thus, the management of Syrian patients has to be tailored accordingly.