Recent Publications
Nir Avital and Meir Shamay: Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate (Proc Natl Acad Sci U S A)
Abortive viral infections are defined as cells that have been infected with a virus but did not produce any progeny virus as a result of the infection. Recent single-cell studies have shown that abortive infection is observed frequently even during infection of susceptible and permissive cell types. Here, we recovered populations of susceptible and permissive cells that survived infection with herpes simplex virus at high multiplicity of infection.
Ibrahim Marai: The efficacy of the LinoxSmart DX ICD lead from a single center experience (Indian Pacing Electrophysiol J)
The Biotronik LinoxSmart DX implanted cardioverter defibrillator (ICD) lead is a novel VDD lead with the advantage of integrated atrial sensing dipole combined with a special augmentation and filtering mechanisms. We sought to determine the efficacy of the Biotronik LinoxSmart DX ICD lead
Baruh Polis and Abraham Samson: Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated (Brain Sci.)
Recently, a study published in "Toxicology In Vitro" (Kate Samardzic and Kenneth J. Rodgers) was entitled: "Cytotoxicity and Mitochondrial Dysfunction Caused by the Dietary Supplement L-Norvaline". The title may be greatly overstated, and here we provide several arguments showing that norvaline is not as toxic as reported.
Autoimmune diseases in first- and second-degree relatives of patients with inflammatory bowel diseases: a case-control survey in Israel (Minerva Med)
The present case-control study was designed to compare the rate of ADs in first- and second-degree relatives of IBD patients, stratified according to Jew or Arabic ethnicity. (Research with affiliate hospitals - The Nazareth Hospital, EMMS; Galilee Medical Center, Nahariya and others)
Schistosomal extracellular vesicle-enclosed miRNAs modulate host T helper cell differentiation (EMBO Rep)
Our results explain, at least partially, how schistosomes tune down the Th2 response, and provide further insight into the reciprocal geographic distribution between high prevalence of parasitic infections and immune disorders such as allergy. Furthermore, this worm-host crosstalk mechanism can be harnessed to develop diagnostic and therapeutic approaches for human schistosomiasis and Th2-associated diseases. (Yiftah Barsheshet, Boris Brant, Orly Avni)
David Azoulay: Flow cytometry aneuploidy and cell cycle indexing as a possible tool for differentiating between CD10+ diffuse large B‐cell lymphoma and follicular lymphoma (Clinical Cytometry)
Differential diagnosis between diffuse large B‐cell lymphoma (DLBCL) and follicular lymphoma (FL) becomes a challenge when adequate biopsy is unavailable. The present study aimed to investigate the applicability of DNA cell cycle analysis by flow cytometry (FC) for differentiating between CD10+ DLBCL and FL.
Hagar Tadmor, Meir Shamay: Kaposi's Sarcoma Associated Herpesvirus LANA Modulates the Stability of the E3 Ubiquitin Ligase RLIM ((J Virol)
Adds another way a viral protein can regulate cellular protein stability, by enhancing the auto-ubiquitination and degradation of an E3 ubiquitin ligase.
Zaher Armaly: Impact of pretreatment with carnitine and tadalafil on contrast-induced nephropathy in CKD patients (Ren Fail.)
Research with affiliate hospitals (Nazareth Hospital EMMS, Ziv Medical Center).
Assisted Reproductive Technology as a Transcutaneous Route for Bacterial Contamination of Ovarian Endometrioma with Coagulase-Negative Staphylococcus: Case Report and Review of the Literature (Infect Dis Obstet Gynecol.)
Tubo-ovarian abscess may develop in women with endometrioma following assisted reproductive technology (ART). The infection, though rare, is typically late in onset and may present several months after the procedure, and in pregnancy—with the risks of abortion and premature labor.... We discuss the challenges in diagnosis and treatment of this rare condition and the implications of the discovery that an organism previously dismissed as a contaminant has emerged as a causative organism in severe, deep-seated infections of soft tissues in recent literature. (Shimon Edelstein, Inbar Ben Shachar, Hila Ben-Amram, Seema Biswas, and Naama Marcus)
Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia: A Rare Case Report from Nephrology (Am J Case Rep)
Research with affiliate hospitals (Nazareth Hospital EMMS, HaEmeq Hospital) - nephrology, internal medicine, lab, radiology.
Andrei Braester and Masad Barhoum: Triple Negative Mutations in Essential Thrombocythemia With bcr-abl Rearrangement: Is There a Such Distinct Disease? (Am J Med Sci)
We propose criteria that can retain ET/bcr-abl+ as a separate entity: clinical, laboratory and morphologic (morphology of bone marrow).
The association between non-alcoholic fatty liver disease and valvular heart disease (Minerva Cardioangiol.)
Non-alcoholic fatty liver (NAFLD) disease has become the commonest cause of end-stage liver disease. Patients with NAFLD have an increased risk of associated extrahepatic conditions, including structural and functional cardiovascular disease. Still, it is unknown if there is an association between NAFLD and valvular heart disease (VHD). (Research with affiliate hospitals - Nazareth Hospital EMMS; Galilee Medical Center, Nahariya)
Prenatal low-dose penicillin results in long-term sex-specific changes to murine behaviour, immune regulation, and gut microbiota (Brain Behav Immun)
Growing evidence suggests that environmental disruptors of maternal microbes may have significant detrimental consequences for the developing fetus. . . . These data suggest that exposure of pregnant mice to even a low dose of penicillin through only the last week before birth is nonetheless sufficient to induce long-term sex-specific developmental changes in both male and female offspring. (Champagne-Jorgensen K, Firoz Mian M, Kay S, Hanani H, Ziv O, McVey Neufeld KA, Koren O, Bienenstock J)
Shahar Koffler, Ayelet Shai: Association between palliative care and the rate of advanced care planning: A systematic review (Palliative and Supportive Care)
Reviews the evidence on the association between routine palliative care and rate of advanced care planning, and concludes that if we wish to increase patients' awareness and compliance with advanced care planning we should improve access to early palliative care. (Shahar Koffler, Yishai Mintzker, Ayelet Shai)
Mohammad Adawi: FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study (Front Immunol.)
To test the hypothesis that familial Mediterranean fever (FMF)-associated autoinflammation may exaggerate the tendency toward adaptive immunopathology or spondyloarthritis (SpA)-associated disorders including major histocompatibility complex (MHC) class I associated disorders but not classical MHC class II-associated disorders that exhibit transplacental autoimmunity including myasthenia gravis and pemphigus.