חדשות המחקר
Naaem Simaan: Effects in Israel of Arab and Jewish Ethnicity on Intracerebral Hemorrhage (J Clin Med . )
Intracerebral hemorrhages (ICH) characteristics reportedly differ between different ethnic groups. We aimed to compare the characteristics of Jewish and Arab ICH patients in Israel.
Rola Khamisy-Farah: How to Integrate Sex and Gender Medicine into Medical and Allied Health Profession Undergraduate, Graduate, and Post-Graduate Education: Insights from a Rapid Systematic Literature Review and a Thematic Meta-Synthesis (J Pers Med . )
Sex and gender are concepts that are often misunderstood and misused, being utilized in a biased, preconceived, interchangeable way. Sex and gender medicine is generally overlooked, despite the profound impact of sex and gender on health outcomes. The aims of the present rapid systematic literature review were (i) to assess the extent to which sex- and gender-sensitive topics are covered in medical courses; (ii) to assess the need for and willingness toward integrating/incorporating sex and gender medicine into health-related education; (iii) to identify barriers and facilitators of the process of implementation of sex and gender medicine in medical teaching, mentoring, and training; and (iv) to evaluate the effectiveness of interventional projects targeting curriculum building and improvement for future gender-sensitive physicians.
Ligat Shalev, Anthony Luder, Sivan Spitzer, Danna Krupik, Jumanah Essa-Hadad, Mary C J Rudolf: Keeping our children safe: piloting a hospital-based home-visitation program in Israel (Isr J Health Policy Res)
Unintentional childhood injuries are a leading cause of morbidity and mortality worldwide. Attempts to prevent child home injuries have rarely been implemented in hospital settings which present an important opportunity for intervention. The SHABI ('Keeping our Children Safe; SHomrim Al BetIchut Yeladenu') program recruits at-risk families presenting with child injury to the Emergency Department. Medical/nursing students conduct two home visits and provide safety equipment and guidance. The objective of this study was to investigate the impact of SHABI on participating families' home-safety.
Kamal Abu Jabal, Michael Edelstein: Using SARS-CoV-2 anti-S IgG levels as a marker of previous infection: Example from an Israeli Healthcare worker cohort (Int J Infect Dis .)
Determining COVID19 status is important for global epidemiology and individual-level vaccination decision-making. SARS CoV-2 Infection can generally only be detected during a 7-10 days period using PCR or rapid antigen testing, and infection specific anti nucleocapsid IgG assays are not universally available. We determined whether SARS-CoV-2 anti spike (anti-S) IgG levels could discriminate between vaccination and past infection when interpreted alongside vaccination timing.
Rawan Mahamid, Helal Said Ahmad, Narjes Azzam, Ali Omari, Amir Mari: The yield of solid swallows in high resolution esophageal manometry among patients with dysphagia and gastro-esophageal reflux symptoms (Minerva Gastroenterol (Torino) .)
Swallowing disorders are frequently reported esophageal symptoms and represent a common cause for referrals to gastroenterology consultations. Esophageal high-resolution manometry (HRM) is considered the gold standard modality for the evaluation of esophageal peristalsis and esophageal sphincter. The standard protocol of HRM includes water swallows only, that may not assess appropriately esophageal function and symptoms. Hence, we investigated the diagnostic yield of combining solid food swallows (SFS) to standard HRM.
Inbar Ben Shachar, Ilan Atlas: Does sentinel lymph node biopsy in endometrial cancer surgery have an impact on the rate of adjuvant post operative pelvic radiation? An Israeli Gynecologic Oncology Group Study (Gynecol Oncol Rep. )
Compares the rates of post-operative radiotherapy between two methods of lymph nodes assessment during surgical staging for endometrial cancer (EC).
Paul Kuodi, Yanay Gorelik, Michael Edelstein: Characterisation of the long-term physical and mental health consequences of SARS-CoV-2 infection: A systematic review and meta-analysis protocol (PLoS One . )
As of July 2021, there has been more than 185 million documented cases of the novel coronavirus (SARS-CoV-2) infections and more than 4 million deaths globally. Despite more than 90% of documented cases being classified as "recovered" from SARS-CoV-2 infection, a proportion of patients reported a wide variety of persisting symptoms after the initial onset or acute phase of the infection, often referred to as "Long Covid". As data on the symptomatology of post-acute SARS-CoV-2 infection gradually becomes available, there is an urgent need to organise and synthesise the data in order to define what constitutes Long Covid and assist with its management in clinical and community settings.
Liron Davis, Dmitriy Getselter, Evan Elliott: CTCF in parvalbumin-expressing neurons regulates motor, anxiety and social behavior and neuronal identity (Mol Brain . )
CCCTC-binding factor (CTCF) is a regulator of chromatin organization and has direct effects on gene transcription. Mutations in CTCF have been identified in individuals with neurodevelopmental conditions. There are wide range of behaviors associated with these mutations, including intellectual disabilities, changes in temperament, and autism. Previous mice-model studies have identified roles for CTCF in excitatory neurons in specific behaviors, particularly in regards to learning and memory. However, the role of CTCF in inhibitory neurons is less well defined.
Tal Shachar: Massive Brain Swelling Following Reduction Cranioplasty for Secondary Turricephaly (J Craniofac Surg . )
Cranioplasty is commonly performed to treat craniosynostosis. A rare postsurgical complication is massive brain swelling with elevated intracranial pressure. This commonly presents with mydriasis, coma, and seizures; radiologic findings include cerebral edema, parenchymal hemorrhages, and ischemic changes.The authors describe a 9-year-old boy who developed massive brain swelling following reduction cranioplasty for secondary turricephaly.
Hagar Mizrachi: Cuffing Prisoners and Detainees in Israeli Hospitals - a Multi-center Study (Harefuah .)
Describes the extent of prisoner/detainee cuffing and characterize cuffing methods.
Yana Lerner, Surya Sukumaran, Nir Qvit: Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology (J Vis Exp .)
Biomolecular interactions play versatile roles in numerous cellular processes by regulating and coordinating functionally relevant biological events. Biomolecules such as proteins, carbohydrates, vitamins, fatty acids, nucleic acids, and enzymes are fundamental building blocks of living beings; they assemble into complex networks in biosystems to synchronize a myriad of life events. Proteins typically utilize complex interactome networks to carry out their functions; hence it is mandatory to evaluate such interactions to unravel their importance in cells at both cellular and organism levels. Toward this goal, we introduce a rapidly emerging technology, field-effect biosensing (FEB), to determine specific biomolecular interactions. FEB is a benchtop, label-free, and reliable biomolecular detection technique to determine specific interactions and uses high-quality electronic-based biosensors.
Khalaf Kridin: COVID-19 Booster Vaccination Among Individuals With Schizophrenia in Israel (JAMA Psychiatry . )
Individuals with schizophrenia are at higher risk for severe COVID-19 illness and mortality. Previous reports have demonstrated vaccination gaps among this high-risk population; however, it is unclear whether these gaps have continued to manifest with the booster dose. Objective: To assess gaps in first, second, and booster vaccinations among individuals with schizophrenia.
Sivan Spitzer: Critical Theory, Culture Change, and Achieving Health Equity in Health Care Settings (Acad Med . )
Achieving optimal health for all requires confronting the complex legacies of colonialism and white supremacy embedded in all institutions, including health care institutions. As a result, health care organizations committed to health equity must build the capacity of their staff to recognize the contemporary manifestations of these legacies within the organization and to act to eliminate them. In a culture of equity, all employees-individually and collectively-identify and reflect on the organizational dynamics that reproduce health inequities and engage in activities to transform them. The authors describe 5 interconnected change strategies that their medical center uses to build a culture of equity.
Khalaf Kridin: The association of uveitis with hepatitis B and hepatitis C viruses: a large-scale population-based study (Eye (Lond) .)
Examines the association of uveitis with hepatitis B (HBV) and hepatitis C (HCV) chronic infections