Yaseen Awad-Igbaria, Aviv Ben-Menashe, Reem Sakas, Tom Fishboom, Jean Francois-Soustiel, Eilam Palzur: Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain (Brain .)

Neuropathic pain remains one of the leading causes of global disability. The mechanism of neuropathic pain development and maintenance involves mitochondrial dysfunction induced-neuronal apoptosis of peripheral and central nociceptive pathways. The TRPV1 is a non-selective cation channel, which has a high Ca2+ permeability, playing an essential role in neuronal apoptosis in the spinal cord following peripheral nerve injury. However, the mechanism of how TRPV1 activation in the spinal cord induces mitochondrial dysfunction-mediate neuronal apoptosis, resulting in allodynia is unknown.