ד"ר אברהם סמסון

Peer Reviewed Publications

Polis B., Samson A.O. "Neurogenesis versus neurodegeneration: the broken balance in Alzheimer's disease" 2021 Neural Regeneration Research. 16(3):496-497. PubMed

 

Meirson T., Bomze D., Samson A.O. "κ-helix and the helical lock and key model: A pivotal way of looking at polyproline II" 2020 Bioinformatics. 36(12):3726-3732. PubMed

 

Gilinsky M.A., Polityko Y.K., Markel A.L., Latysheva T.V., Samson A.O., Polis B., Naumenko S.E., "Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension" 2020, Biomed Research International. 2020:4935386. PubMed

 

Polis B., Gurevich V., Bloch N., Bloch N., Samson A.O., "Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer's Disease Mice" 2020, International Journal of Molecular Sciences. 21(3). PubMed

 

Polis B., Samson A.O., "Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders." 2020, Neural Regeneration Research. 15(8):1460-1470. PubMed

 

Meirson T., Gil-Henn H., Samson A.O., "Invasion and metastasis: the elusive hallmark of cancer.", 2020, Oncogene. 39(9):2024-2026 PubMed

 

Meirson T., Bomze D., Kahlon L., Gil-Henn H., Samson A.O. "A helical lock and key model of polyproline II conformation with SH3", 2020, Bioinformatics. 36(1):154-159. PubMed

 

Polis B., Gilinsky M.A., Samson A.O., "Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated.", 2019, Brain Sciences. 17;9(12). PubMed

 

Polis B., Gurevich V., Assa M., Samson A.O., "Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer's Disease", 2019, International Journal of Molecular Sciences. 18;20(18). PubMed

 

Atrahimovich D., Samson A.O., Barsheshet Y., Vaya J., Khatib S., Reuveni E. "Genome-wide localization of the polyphenol quercetin in human monocytes", 2019, BMC Genomics. 20(1):606. PubMed

 

Polis B., Srikanth K.D., Gurevich V., Gil-Henn H., Samson A.O. "L-Norvaline, a new therapeutic agent against Alzheimer's disease", 2019, Neural Regeneration Research. 14(9):1562-1572. PubMed

 

Polis B., Samson A.O. "Arginase as a Potential Target in the Treatment of Alzheimer's Disease", 2018, Advances in Alzheimer's Disease. 7(4), 119-140.

 

Fonar G., Polis B., Meirson T., Maltsev A., Samson A.O. "Subcutaneous Sustained-Release of Poly-Arginine Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease", 2018, Advances in Alzheimer's Disease. 7(4), 153-182.

 

Polis B., Srikanth K.D., Elliott E., Gil-Henn H., Samson A.O. "L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer's Disease.", 2018, Neurotherapeutics. 15(4):1036-1054. PubMed

 

Atrahimovich D, Samson A.O., Khattib A., Vaya J., Khatib S. "Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balb/c Mice Fed a High-Fat Diet", 2018, Oxid Med Cell Longev. 2018:2673076. PubMed

 

Fonar G., Polis B., Meirson T., Maltsev A., Elliott E., Samson A.O. "Intracerebroventricular Administration of L-arginine Improves Spatial Memory Acquisition in Triple Transgenic Mice Via Reduction of Oxidative Stress and Apoptosis.", 2018, Translational Neuroscience. 9:43-53. PubMed

 

Meirson T., Genna A., Lukic N., Makhnii T., Alter J., Sharma V.P., Wang Y., Samson A.O., Condeelis J.S., Gil-Henn H. "Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors.", 2018, Oncotarget. 9(31):22158-22183. PubMed

 

Zattelman L., Regev R., Usaj M., Reinke P.Y.A., Giese S., Samson A. O., Taft M.H., Manstein D.J., Henn A. "N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.", 2017, Journal of Biological Chemistry. 292(43):17804-17818. PubMed

 

Glantz-Gashai Y., Meirson T., Reuveni E., Samson A. O. "Virtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance.", 2017, Drug Design Development and Therapy. 11:1803-1813. PubMed

 

Meirson T., Samson A. O., Gil-Henn H. "An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2.", 2017, Drug Design Development and Therapy. 11:1535-1557. PubMed

 

Aran A., Segel R., Kaneshige K., Gulsuner S., Renbaum P., Oliphant S., Meirson T., Weinberg-Shukron A., Hershkovitz Y., Zeligson S., Lee M.K., Samson A. O., Parsons S.M., King M.C., Levy-Lahad E., Walsh T. "Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome", 2017, Neurology. 88:1021-1028. PubMed

 

Falik Zaccai T.C., Savitzki D., Zivony-Elboum Y., Vilboux T., Fitts E.C., Shoval Y., Kalfon L., Samra N., Keren Z., Gross B., Chasnyk N., Straussberg R., Mullikin J.C., Teer J.K., Geiger D., Kornitzer D., Bitterman-Deutsch O., Samson A. O., Wakamiya M., Peterson J.W., Kirtley M.L., Pinchuk I.V., Baze W.B., Gahl W.A., Kleta R., Anikster Y., Chopra A.K. "Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy." 2017, Brain. 140:370-386. PubMed

 

Glantz-Gashai Y., Meirson T., and Samson A. O. "Normal Modes Expose Active Sites in Enzymes", 2016, PLoS Comput Biol. 21,12. PubMed

 

Dabour R., Meirson T., and Samson A. O. "Global antibiotic resistance is mostly periodic" 2016, J Glob Antimicrob Resist. 7:132-134. PubMed

 

Atrahimovich D., Khatib S., Sela S., Vaya J., and Samson A. O. "Punicalagin Induces Serum Low-Density Lipoprotein Influx to Macrophages" 2016, Oxid Med Cell Longev. 2016:71242-51. PubMed

 

Reuveni E., Samson A. O., and Giuliani A., "Principal component analysis of mouse genomes unravels strong genetic robustness during evolution" 2015, International J of Medical Biotech and Genetics. 1:1-6. PubMed

 

Weinberg-Shukron A., Renbaum P., Kalifa R., Zeligson S., Ben-Neriah Z., Dreifuss A., Abu-Rayyan A., Maatuk N, Fardian N, Rekler D, Kanaan M, Samson A.O., Levy-Lahad E, Gerlitz O, and Zangen D. "A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis" , 2015, The Journal of Clinical Investigation. 125:4295-304. PubMed

 

Fonar G., and Samson A. O. "NMR structure of the water soluble Aβ17-34 peptide", 2014, Bioscience Reports. 34(6):e00155 Pubmed

 

Maatuk N., Glantz-Gashai Y., Rotman M., Baydany M., Fonar G., Shechvitz A., Shemer K., Peleg A., Reuveni E., and Samson A. O. "PHI-DAC: protein homology database through dihedral angle conservation", 2014, Bioinformatics. 31(2):292-4 PubMed

 

Greenberger M. M., and Samson A. O. "Normal mode dynamics of voltage-gated K+ channels: gating principle, opening mechanism, and inhibition", 2014, Journal of Computational Neuroscience. 38(1):83-8 PubMed

 

Kolan D., Fonar G., and Samson A. O.. "Elastic network normal modes reveal the GPCR activation mechanism", 2013, Protein: Structure, Function, and Bioinformatics. 82(4):579-86 PubMed

 

Kolodny R., Pereyeslavets L., Samson A. O., and Levitt M. "On the universe of protein folds", 2013, Annual Review of Biophysics, 42, 559-582. PubMed

 

Maatuk N., and Samson A. O. "Modeling the binding mechanism of Alzheimer's Aβ(1-42) to nicotinic acetylcholine receptors based on similarity with snake α-neurotoxins.", 2012, Neurotoxicology, 50, 2243-8. PubMed

 

Samson A. O., and Levitt M., "Normal modes of prion proteins: from native to infectious particle", 2011, Biochemistry, 50, 2243-8. PubMed

 

Samson A. O., and Levitt M., " Protein segment finder: an online search engine for segment motifs in the PDB", 2009, Nucleic Acid Research, 37 (Database issue), D224-8. PubMed

 

Samson A. O., and Levitt M., "Inhibition mechanism of the acetylcholine receptor by α-neurotoxins as revealed by normal mode dynamics", 2008, Biochemistry, 47, 4065-4070. PubMed

 

Rosen O., Samson A.O., and Anglister J., "Correlated mutations at gp120 positions 322 and 440: implications for gp120 structure", 2008, Proteins, 71, 1066-70. PubMed

 

Rosen O., Samson A. O., Sharon M., Zolla-Pazner S., and Anglister J., "Response to Matters Arising ", 2006, Structure, 14, 649-651.

 

Samson A. O., and Anglister J., "2D-measurement of proton T_1π relaxation in unlabeled proteins: α-bungarotoxin complex with acetylcholine receptor peptide", 2005, Biochemistry, 44, 10926-10934. PubMed

 

Biron Z., Khare S., Samson A.O., Naider F., and Anglister J. "A monomeric 3₁₀-helix is formed in water by a 13-residue peptide representing the neutralizing determinant of HIV-1 on gp41" , 2002, Biochemistry, 41, 12687-12696. PubMed

 

Yassin L., Samson A.O., Halevi S., Eshel M., and Treinin M., "Mutations in the extracellular domain and in the membrane spanning domains interfere with nicotinic acetylcholine receptor maturation", 2002, Biochemistry, 41, 12329-12335. PubMed

 

Samson A.O., Scherf. T., Eisenstein M., Chill J., and Anglister J., "The mechanism for acetylcholine receptor inhibition by α-neurotoxins and species-specific resistance to α-bungarotoxin revealed by NMR", 2002, Neuron, 35, 319-332. Pubmed

 

Yao Y., Wang J., Viroonchatapan N., Rothe E., Samson A.O., Chill J., Anglister J., and Wang Z. "Yeast expression and NMR analysis of the extracellular domain of muscle nicotinic acetylcholine receptor α-subunit", 2002, Journal of Biological Chemistry, 277(15), 12613-12621. Pubmed

 

Samson A.O., Chill J., Rodriguez E., Scherf T., and Anglister J., "NMR mapping and secondary structure determination of the major acetylcholine receptor α-subunit determinant interacting with α-bungarotoxin", 2001, Biochemistry, 40, 5464-5473. Pubmed

 

Books

Polis B., Samson A.O. "Arginase as a potent​ial target in the treatment of Alzheimer's disease" (2018) Lambert academic publishing.

 

 

Book chapters

Polis, B. Samson A. O. A New Perspective on Alzheimer's Disease as a Brain Expression of a Complex Metabolic Disorder. 2019, In: Wisniewski T., editor. Alzheimer's Disease. Brisbane (AU): Codon Publications. Chapter 1. Pubmed

 

Samson A. O., Scherf T., Eisenstein M., Chill J. H., and Anglister J., "The mechanism for acetylcholine receptor inhibition by α-neurotoxins and species specific resistance to α-bungarotoxin revealed by NMR" 2004, Cholinergic mechanisms, function and dysfunction, p.45-54, Taylor & Francis group, UK.

 

Samson A. O., Scherf T., Eisenstein M., and Anglister J., "Interactions of toxins with cholinergic proteins", 2004, Cholinesterases in the second millenium: Biomolecular and Pathological Aspects, p.285-93, Diseño e Impresiones Ltda. press. Pucon, Chile.