Recent Publications
The association between non-alcoholic fatty liver disease and valvular heart disease (Minerva Cardioangiol.)
Non-alcoholic fatty liver (NAFLD) disease has become the commonest cause of end-stage liver disease. Patients with NAFLD have an increased risk of associated extrahepatic conditions, including structural and functional cardiovascular disease. Still, it is unknown if there is an association between NAFLD and valvular heart disease (VHD). (Research with affiliate hospitals - Nazareth Hospital EMMS; Galilee Medical Center, Nahariya)
Prenatal low-dose penicillin results in long-term sex-specific changes to murine behaviour, immune regulation, and gut microbiota (Brain Behav Immun)
Growing evidence suggests that environmental disruptors of maternal microbes may have significant detrimental consequences for the developing fetus. . . . These data suggest that exposure of pregnant mice to even a low dose of penicillin through only the last week before birth is nonetheless sufficient to induce long-term sex-specific developmental changes in both male and female offspring. (Champagne-Jorgensen K, Firoz Mian M, Kay S, Hanani H, Ziv O, McVey Neufeld KA, Koren O, Bienenstock J)
Shahar Koffler, Ayelet Shai: Association between palliative care and the rate of advanced care planning: A systematic review (Palliative and Supportive Care)
Reviews the evidence on the association between routine palliative care and rate of advanced care planning, and concludes that if we wish to increase patients' awareness and compliance with advanced care planning we should improve access to early palliative care. (Shahar Koffler, Yishai Mintzker, Ayelet Shai)
Mohammad Adawi: FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study (Front Immunol.)
To test the hypothesis that familial Mediterranean fever (FMF)-associated autoinflammation may exaggerate the tendency toward adaptive immunopathology or spondyloarthritis (SpA)-associated disorders including major histocompatibility complex (MHC) class I associated disorders but not classical MHC class II-associated disorders that exhibit transplacental autoimmunity including myasthenia gravis and pemphigus.
Omry Koren: Interactions between the Gut Microbiome and Mucosal Immunoglobulins A, M, and G in the Developing Infant Gut (mSystems)
Interactions between the gut microbiome and immunoglobulin A (IgA) in the gut during infancy are important for future health. IgM and IgG are also present in the gut; however, their interactions with the microbiome in the developing infant remain to be characterized. . . . results provide a better understanding of how these antibodies interact with the developing infant gut microbiome.
Daniel Glikman: Cat scratch disease presenting as fever of unknown origin is a unique clinical syndrome (Clin Infect Dis.)
Fever of unknown origin (FUO) is a rare manifestation of cat scratch disease (CSD). Data regarding CSD associated FUO (CSD-FUO), particularly in adults, are limited. We aimed to study disease manifestations and long-term clinical outcome.
Sheathless guiding catheter from a femoral approach for complex percutaneous coronary interventions -An unusual solution for an often-encountered problem (Clin Case Rep)
Sheathless guiding catheters are a valuable tool in the catheterization labor and may assist the operator when dealing with heavily calcified and tortuous vessels. Nevertheless, when hostile anatomy prevents successful percutaneous coronary interventions (PCI) from the radial access, transfemoral use of sheathless guide can assist in overcoming these challenges in a safe manner. (Zeev Israeli, Irina Nordkin, Alexander Goldberg, Majdi Halabi)
Tawfik Khoury: Introducing Patterns of Variability for Overcoming Compensatory Adaptation of the Immune System to Immunomodulatory Agents: A Novel Method for Improving Clinical Response to Anti-TNF Therapies (Front Immunol.)
We review the mechanisms and methods for predicting LOR and the currently used methods for overcoming the ineffectiveness of anti-TNFs.
Predicting common bile duct stones by non-invasive parameters (Hepatobiliary Pancreat Dis Int.)
Research with affiliate hospitals (Galilee Medical Center, Nahariya; The Nazareth Hospital, EMMS, Nazareth).
Milana Frenkel-Morgenstern:ChiTaRS 5.0: the comprehensive database of chimeric transcripts matched with druggable fusions and 3D chromatin maps (Nucleic Acids Res)
The Laboratory of Cancer Genomics and Biocomputing of Complex Diseases (Balamurali D, Gorohovski A, Detroja R, Palande V, Raviv-Shay D, Frenkel-Morgenstern M.)
Avi Peretz: The diagnostic performance and accuracy of 3 molecular assays for the detection of Clostridium difficile in stool samples, compared with the Xpert® C. difficile assay (J Microbiol Methods.)
This research compares the performance and diagnostic accuracy of three molecular tests for the detection of Clostridium difficile in stool samples, with the Xpert® C. difficile assay.
Tomer Meirson: Invasion and metastasis: the elusive hallmark of cancer (Oncogene)
Azrieli Faculty of Medicine MD-PhD student with Dr. Hava Gil-Henn and Dr. Abraham O. Samson. In Oncogene (2019) doi:10.1038/s41388-019-1110-1
Simple Bedside Predictors of Survival after Percutaneous Gastrostomy Tube Insertion (Can J Gastroenterol Hepatol.)
We aimed to explore a simple noninvasive parameter that would predict survival following PEG insertion. (Wisam Sbeit, Anas Kadah, Amir Mari, Mahmud Mahamid, and Tawfik Khoury )
Nir Qvit: Approach for comparing protein structures and origami models (Biochim Biophys Acta Biomembr. 2019 Nov 15:183132)
"We propose a general approach for comparing protein structures with origami models....our analysis suggests that there are similar patterns between protein structures and origami models and that this approach may provide an important insight on the role that the structure of a protein fulfils, and on preferred structural design of novel proteins with unique characteristics."