Recent Publications
Baruh Polis, Abraham O. Samson: Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders (Neural Regen Res.)
Alzheimer’s disease is an incurable chronic neurodegenerative disorder and the leading cause of dementia, imposing a growing economic burden upon society. The disease progression is associated with gradual deposition of amyloid plaques and the formation of neurofibrillary tangles within the brain parenchyma, yet severe dementia is the culminating phase of the enduring pathology. Converging evidence suggests that Alzheimer’s disease-related cognitive decline is the outcome of an extremely complex and persistent pathophysiological process.... approaches targeting amyloid-beta or Tau are not adequate to cure the disease. Accordingly, the modern scientific vision of Alzheimer’s disease etiology and pathogenesis must reach beyond the hallmarks, and look for alternative strategies and areas of research.
Saad Elias, Sbeit Wisam, Barhoum Masad, Levy Gali, and Assy Nimer: Seasonal Patterns of Acute Esophageal Variceal Bleeding In Patients with Liver Cirrhosis (Japanese J Gstro Hepato.)
Seasonal variations in the incidence of esophageal variceal bleeding in patients with end stage liver disease have been explored in various studies but the results were inconsistent. In the present retrospective analysis, consecutive patients with liver cirrhosis admitted with esophageal variceal bleeding to the Galilee medical center from 2010 until 2015 were evaluated.
Sino-Nasal Outcome Test-22: Cross-cultural Adaptation, and Validation in Russian Speaking Patients (Clin Otolaryngol. )
Chronic rhinosinusitis (CRS) is a relatively common disease which significantly affects the patient's quality of life (QoL). Sino‐Nasal Outcome Test–22 (SNOT‐22) is a QoL questionnaire which allows quantifying patients' complaints. Our aim was to translate and validated the SNOT‐22 into the Russian language. (Netanel Eisenbach, Tal Marshak, Ohad Ronen)
Amir Hadanny: Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis (Restor Neurol Neurosci.)
Previous studies have shown that hyperbaric oxygen therapy (HBOT) can improve the motor functions and memory of post-stroke patients in the chronic stage.
The aim of this study is to evaluate the effects of HBOT on overall cognitive functions of post-stroke patients in the chronic stage. The nature, type and location of the stroke were investigated as possible modifiers.The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders (Curr Opin Neurobiol.)
There is growing evidence for the involvement of the gut-microbiota in the regulation of emotions, behavior, and higher cognitive functions through the 'microbiome-gut-brain axis'. This relationship between the gut microbiota and the brain is pivotal for the development of the newborn, which receives its commensal microbiota at birth; dysbiosis may result in altered neurodevelopment. The hypothalamus-pituitary-adrenocortical (HPA) axis is actively involved in the stress response but is undeveloped in the newborn. Here, we describe how changes in the commensal microbiota influence the normal development of the HPA axis and review recent findings describing the essential crosstalk between the gut microbiota and the HPA axis and suggesting a role for the maternal and commensal microbiota in the development of the HPA axis and of the stress response. (Linoy Mia Frankiensztajn, Evan Elliott, Omry Koren)
Keren Agay-Shay: Unconventional oil and gas development and health outcomes: A scoping review of the epidemiological research (Environ Res.)
Study conducted a scoping review to assess what is known about the human health outcomes associated with exposure to unconventional oil and gas (UOG) development.
Elon Glassberg: A Randomized Trial of Mentored vs Nonmentored Military Medics Compared in the Application of a Wound Clamp Without Prior Training: When to Shut Up and Just Watch! (Mil Med.)
Hemorrhage control is a basic task required of first responders and typically requires technical interventions during stressful circumstances. Remote telementoring (RTM) utilizes information technology to guide inexperienced providers, but when this is useful remains undefined. Military medics were randomized to mentoring or not from an experienced subject matter expert during the application of a wound clamp (WC) to a simulated bleed. Inexperienced, nonmentored medics were given a 30-second safety briefing; mentored medics were not. Objective outcomes were time to task completion and success in arresting simulated bleeding.
Amiel A. Dror, Eyal Sela: A mouse model for benign paroxysmal positional vertigo (BPPV) with genetic predisposition for displaced otoconia (Genes Brain Behav.)
This unique mouse model can serve as a platform for further investigation of BPPV pathophysiology, and for developing novel treatment approaches in a live animal model.
Noa Alpert, Ziv Paz: Clinical characteristics and outcomes of patients with septic arthritis treated without surgery (Eur J Clin Microbiol Infect Dis)
These findings support the nonsurgical approach as effective for patients with septic arthritis who are not critically ill at time of presentation.
David Karasik: Searching for parent-of-origin effects on cardiometabolic traits in imprinted genomic regions (Eur J Hum Genet.)
Cardiometabolic traits pose a major global public health burden. Large-scale genome-wide association studies (GWAS) have identified multiple loci accounting for up to 30% of the genetic variance in complex traits such as cardiometabolic traits. However, the contribution of parent-of-origin effects (POEs) to complex traits has been largely ignored in GWAS. Family-based studies enable the assessment of POEs in genetic association analyses. We investigated POEs on a range of complex traits in 3 family-based studies.
Naama Marcus Braun: Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse (Int Braz J Urol.)
There are many risk factors associated with pelvic organ prolapse and this review aims to identify the epidemiology and pathophysiology while looking at the known risk factors for pelvic organ prolapse.
Nimrod Rahamimov: Nylon Skin Sutures Carry a Lower Risk of Post-Operative Infection than Metal Staples in Open Posterior Spine Surgery: A Retrospective Case-Control Study of 270 Patients (Surg Infect (Larchmt))
In our departmental setting, closure of the skin incision with nylon sutures after open posterior spine surgery carried a significantly lower risk of post-operative SSI compared with metal staples. The generalizability of our findings is unclear, but they warrant further investigation.
Chaim Putterman: Advances in the diagnosis, pathogenesis and treatment of neuropsychiatric systemic lupus erythematosus (Curr Opin Rheumatol)
Diagnosing and treating neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging as the pathogenesis is still being debated. In this review, we discuss studies evaluating recent advances in diagnostic methods, pathogenic mediators and potential treatments.
Monomeric cohesin state revealed by live-cell single-molecule spectroscopy (EMBO Rep)
The cohesin complex plays an important role in the maintenance of genome stability....we investigate the role of cohesin dynamics and stoichiometry in live yeast cells at single‐molecule resolution....Our results demonstrate that single‐molecule tools have the potential to provide new insights into the cohesin mechanism of action in live cells. (Elisheva Biton, Anjali Pathania, Avi Matityahu, Itay Onn)