Recent Publications
Hanna Mandel, Tzipora C Falik-Zaccai: Genetic defects in peroxisome morphogenesis (Pex11β, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism (J Inherit Metab Dis .)
Peroxisomes are essential organelles involved in lipid metabolisms including plasmalogen biosynthesis and β-oxidation of very long-chain fatty acids. Peroxisomes proliferate by the growth and division of pre-existing peroxisomes. The peroxisomal membrane is elongated by Pex11β and then divided by the dynamin-like GTPase, DLP1 (also known as DRP1 encoded by DNM1L gene), which also functions as a fission factor for mitochondria. Nucleoside diphosphate kinase 3 (NME3) localized in both peroxisomes and mitochondria generates GTP for DLP1 activity. Deficiencies of either of these factors induce abnormal morphology of peroxisomes and/or mitochondria, and are associated with central nervous system dysfunction. To investigate whether the impaired division of peroxisomes affects lipid metabolisms, we assessed the phospholipid composition of cells lacking each of the different division factors.
Jumanah Essa-Hadad: The impact of Muslim and Christian religious leaders responding to COVID-19 in Israel (Front Public Health . )
The COVID-19 pandemic is one of the most significant public health emergencies in decades and has affected all countries worldwide. Religious leaders have been recognized as playing a pivotal role in health promotion during times of crisis. This study explored the role that Muslim and Christian religious leaders played in Israel during the pandemic, and the impact that their activities had on the community.
Shemy Carasso: Impact of Short-Acting Disopyramide on Left Ventricular Mechanics Evaluated by Strain Analysis in Patients with Hypertrophic Obstructive Cardiomyopathy (J Clin Med . )
Disopyramide is a class Ia antiarrhythmic drug that has been used for the second-line treatment of symptomatic hypertrophic obstructive cardiomyopathy (HOCM). The aim of the study was to assess the impact of short-acting disopyramide in patients with hypertrophic obstructive cardiomyopathy (HOCM) using two-dimensional speckle-tracking echocardiography.
Gassan Moady, Otman Aliת Rania Sweid, Shaul Atar: The Role of Stress in Stable Patients with Takotsubo Syndrome-Does the Trigger Matter? (J Clin Med . )
Takotsubo syndrome (TTS) is a unique type of reversible cardiomyopathy that predominantly affects elderly women. The role of physical and emotional stress in the pathophysiology of TTS is well established. However, the association between preceding emotional triggers and clinical outcomes in stable patients has not yet been fully investigated. We aimed to investigate the association between emotional triggers before symptom onset and clinical outcomes in stable patients with TTS.
Third trimester re-screening for gestational diabetes in morbidly obese women despite earlier negative test can reveal risks for obstetrical complications (J Obstet Gynaecol Res . )
We investigated associations of maternal obesity with late gestational diabetes mellitus (GDM) diagnosis (>34 weeks) in women with previous normal glucose screening, and associations of late GDM with obstetrical outcomes.
Raneen Abu Shqara, Shany Or, Yara Nakhleh Francis, Lior Lowenstein, Maya Frank Wolf
Shams Twafra , Tal Sneh, Kolluru D Srikanth, Tomer Meirson, Alessandro Genna, Hava Gil-Henn: Correction: A novel Pyk2-derived peptide inhibits invadopodia-mediated breast cancer metastasis (Oncogene . )
Erratum for A novel Pyk2-derived peptide inhibits invadopodia-mediated breast cancer metastasis. Twafra S, Sokolik CG, Sneh T, Srikanth KD, Meirson T, Genna A, Chill JH, Gil-Henn H.
Khalaf Kridin: Management and treatment outcome of DRESS patients in Europe: an international multicentre retrospective study of 141 cases (J Eur Acad Dermatol Venereol . )
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. Objective: To explore treatment approaches across Europe and their impact on the disease course, as well as prognostic factors and culprit drugs.
Jacob Bornstein: High-risk HPV testing vs liquid-based cytology for cervical cancer screening among 25- to 30-year-old women: A historical cohort study (Acta Obstet Gynecol Scand .)
High-risk human papilloma virus (hrHPV) DNA testing is more sensitive than cytology screening, achieving greater protection against cervical cancer. Controversy exists regarding the preferred screening method for women 25-30 years of age. At this age, infection with HPV is common and usually transient. Consequently, hrHPV screening in this age group is fraught with high false-positive screening results, leading to more colposcopies and unnecessary treatments with the potential for harm. In the present study, we aimed to compare the results of two screening methods in relation to high-grade cervical intraepithelial lesion detection rate in the young age group of 25-30 years.
Michael Rechter, Sivan Saraph, Hector Cohen, Ohad Ronen: Nondiagnostic Test Result Rates Following Thyroid Extra-Fine-Needle Aspiration (Am J Clin Pathol. )
The first Bethesda classification category of thyroid fine-needle aspiration biopsy (FNAB) is nondiagnostic (ND), which indicates that the specimen's cellularity is inadequate for evaluation. This work investigated the effect of needle diameter size on ND rates by comparing diagnostic outcomes of FNAB samples collected with 23-, 25-, and 27-gauge needles.
Raneen Abu Shqara, Shay Bussidan, Daniel Glikman, Hagai Rechnitzer, Lior Lowenstein, Maya Frank Wolf: Clinical implications of uterine cultures obtained during urgent caesarean section (Aust N Z J Obstet Gynaecol . )
Postpartum endometritis (PPE) is 12-25 times more common following caesarean sections (CS) performed after labour onset than after vaginal delivery. Risk factors for PPE include prolonged rupture of membranes (ROM), chorioamnionitis, prolonged labour, multiple cervical examinations and Group B Streptococcus colonisation of the lower genital tract. Aims: We compared uterine culture results and microbial antibiotic susceptibility according to ROM duration in emergent intrapartum CS. Secondary outcomes included PPE incidence, and identification of clinical and microbiological predictors of infectious postpartum morbidity.
Dana Cohen, Ronen Sloma, Ayalla Fedida, Limor Kalfon, Relli Ovadia, Zvi Segal, Yanir Kassif, Tzippi Falik Zaccai : Long term ophthalmic complications of distal arthrogryposis type 5D (Ophthalmic Genet .)
Distal Arthrogryposis type 5D (DA5D) is a rare genetic disease, expressed phenotypically by skeletal and ocular abnormalities.
Amani Daoud, Netanel Eisenbach, Ohad Ronen, Amiel Dror, Tali Jane Ohayon, Majd Hajouj, Eyal Sela, Tal Marshak: Cross-cultural adaptation of the Hebrew Nasal Obstruction Symptom Evaluation (NOSE) scale (Laryngoscope Investig Otolaryngol . )
Nasal obstruction is a common complaint. The Nasal Obstruction Symptom Evaluation scale (NOSE) is a reliable validated tool used to assess the quality of life of patients with nasal obstruction. The purpose of this study is to validate the Hebrew version of the NOSE scale (He-NOSE).
Tomer Meirson: Systemic review of the robustness of randomized controlled trials for the treatment of cholangiocarcinoma in three domains: survival-inferred fragility index, restricted mean survival time, and the spin effect (Hepatobiliary Surg Nutr .)
The vast majority of patients with cholangiocarcinoma (CC) have advanced disease at diagnosis and are candidates for palliative treatment only. The robustness of the randomized controlled trials regarding the treatment of CC are assessed.
Avi Benov: Combat Injury Profile in Urban Warfare (Mil Med . )
Combat ground maneuvers consist of various platforms and have several environmental characteristics, influenced by the terrain, the operational mission, and the force's capabilities. This study assesses data on injuries sustained during urban warfare, aiming to evaluate the relationship between injury characteristics, maneuver platform, and personal protective gear on the battlefield.