Recent Publications

Accumulating evidence supports the role of microbiota in autoimmune processes, but research regarding the role of the gut microbiota in celiac disease (CD) is still emerging, and a consistent CD-associated dysbiosis pattern has not yet been defined. Here, we characterized the microbiota of children newly diagnosed with CD, with their unaffected family members as a healthy control group to reduce confounding factors including genetic background, hygiene, dietary habits, and environment, and followed children with CD over 1 year of dietary intervention (exclusion of gluten) to understand if the microbiota is associated with CD and its mediation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a global health concern three years after its emergence. Safe and effective vaccines mitigate the pandemic impact but the optimal schedule remains unclear especially in a context where a high proportion of the population was infected.

(Michael Edelstein, Karine Wiegler Beiruti, Hila Ben-Amram, Netta Beer, Christian Sussan, Perachel Batya, Salman Zarka, Kamal Abu Jabal)

While cell division is essential for self-renewal and differentiation of stem cells and progenitors, dormancy is required to maintain the structure and function of the stem-cell niche. Here we use the hair follicle to show that during growth, the mesenchymal niche of the hair follicle, the dermal papilla (DP), is maintained quiescent by the activity of Hdac1 and Hdac2 in the DP that suppresses the expression of cell-cycle genes.

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High-resolution manometry (HRM) is the gold standard for diagnosing esophageal motility disorders, yet it can be poorly tolerated and technically challenging. 

This review will narrate the anti-cancer activity and characteristics of phytosomes derived from edible plants as well as describe studies which have utilized phytosomes as drug delivery vehicles for cancer with the ultimate objective of significantly reducing the adverse effects associated with conventional therapeutic approaches.

Hyper-inflammatory immune response, a hallmark of severe COVID-19, is associated with increased mortality. Acute respiratory distress syndrome (ARDS) is a common manifestation. We undertook two phase I/II studies in five and then 16 subjects with severe/critical COVID-19 to assess the safety and preliminary efficacy of apoptotic cells (Allocetra™-OTS, Enlivex Therapeutics), a cellular immunomodulatory therapy that reprograms macrophages to reduce hyper-inflammatory response severity.

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Spontaneous cerebrospinal fluid (CSF) leak into the temporal air spaces is a prominent risk factor for meningitis, often leading to debilitating neurological morbidities and even death. CSF leaks may arise due to trauma, congenital malformation, or surgery, but in most cases, they develop spontaneously. In spontaneous CSF leaks, no obvious triggering event is apparent in the patient's clinical history that points to this diagnosis, in contrast to some of the other etiologies. The clinical presentation of spontaneous CSF leaks is not unique and is characterized by patients' complaints, such as hearing loss and aural fullness. These symptoms are commonly associated with prevalent conditions, such as serous otitis media. For these reasons, a typical diagnostic delay of spontaneous CSF leaks, which can last for years in some cases, leaves the patients exposed to meningeal infection without being offered an efficient surgical treatment to keep them safe and protected.

The video head impulse test (vHIT) is a new tool in the vestibular tests' arsenal. It is based on the clinical Head Impulse Test, where the integrity of the vestibulo-ocular reflex is tested by high frequency excitation of the semi-circular canals. The vHIT system is composed of an accelerometer measuring the head movements, and a high frequency infra-red camera for eye tracking mounted on a light-weighted goggles. The main measures obtained are the vestibulo-ocular reflex gain - the ratio between the head and eye velocities, and the recording of corrective saccades taking place during the head movement (covered saccades) or following it (overt saccades).

While the bedside head impulse test evaluates the presence of refixation saccades (RS) as a measure of failing vestibulo-ocular reflex (VOR) the VOR gain calculated by the video head-impulse test (vHIT) is considered the primary measure for semicircular canal function while the role RS is still under evaluation. Aims: To evaluate the benefit of various RS characteristics towards the diagnosis of the left horizontal semicircular function by vHIT.

Genetic etiologies are estimated to account for a large portion of chronic kidney diseases (CKD) in children. However, data are lacking regarding the true prevalence of monogenic etiologies stemming from an unselected population screen of children with advanced CKD.

We conducted a systematic review and meta-analysis to evaluate the association between gestational diabetes mellitus and infections during pregnancy.

This study aimed to investigate the differences in intracerebral hemorrhage (ICH) between Jews and Arabs residing in northern Israel, focusing on risk factors, hemorrhage volume, and functional outcome.