Recent Publications
Nikola Lukic, Trishna Saha, Stefanie Lapetina, Michal Gendler, Gilad Lehmann, Hava Gil-Henn: Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy (J Vis Exp .)
The development and homeostasis of multicellular organisms rely on coordinated regulation of cell migration. Cell migration is an essential event in the construction and regeneration of tissues, and is critical in embryonic development, immunological responses, and wound healing. Dysregulation of cell motility contributes to pathological disorders, such as chronic inflammation and cancer metastasis. Cell migration, tissue invasion, axon, and dendrite outgrowth all initiate with actin polymerization-mediated cell-edge protrusions. Here, we describe a simple, efficient, time-saving method for the imaging and quantitative analysis of cell-edge protrusion dynamics during spreading.
Mohammad E Naffaa, Fadi Hassan, Avivit Golan-Cohen, Ilan Green, Amir Saab, Ziv Paz: Factors associated with drug survival on first biologic therapy in patients with rheumatoid arthritis: a population-based cohort study (Rheumatol Int . )
Lack of sufficient head-to-head trials comparing biologic disease-modifying antirheumatic drugs (bDMARDs) in rheumatoid arthritis (RA), makes the choice of the first bDMARD a matter of rheumatologist's preference. Longer drug survival on the first bDMARD usually correlates with early remission. We aimed to identify factors associated with longer drug survival
Yanay Gorelik, Michael Edelstein: Inequalities in initiation of COVID19 vaccination by age and population group in Israel- December 2020-July 2021 (Lancet Reg Health Eur .)
COVID19 vaccination coverage in Israel varies among population groups. Comparing crude coverage between groups is misleading because of different age structures and socio-economic differences. To describe inequalities in COVID19 vaccine initiation in Israel we analysed the interaction of age and population groups in terms of dose 1 vaccine coverage.
Ibrahim Marai, Matan Shimron, Eevgeni Hazanov, Wadia Kinany, Liza Grosman-Rimon, Offer Amir, Shemy Carasso: Left atrial function analysis in patients in sinus rhythm, normal left ventricular function and indeterminate diastolic function (Int J Cardiovasc
Assessment of diastolic function by echocardiography may be indeterminate as demonstrated in previous studies where diastolic measurement is a discrepant. We aimed to assess whether left atrial (LA) function may contribute to left ventricle filling evaluation in patients with indeterminate diastolic function (IndtDFx).
Michal Werbner, Joel Alter, Moshe Dessau, Meital Gal-Tanamy: BNT162b2 mRNA vaccine elicited antibody response in blood and milk of breastfeeding women (Nat Commun .)
The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine.
Hava Gil-Henn: Inhibition of Vasculogenic Mimicry and Angiogenesis by an Anti-EGFR IgG1-Human Endostatin-P125A Fusion Protein Reduces Triple Negative Breast Cancer Metastases (Cells .)
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options. Metastasis is the major cause of TNBC mortality. Angiogenesis facilitates TNBC metastases. Many TNBCs also form vascular channels lined by tumor cells rather than endothelial cells, known as 'vasculogenic mimicry' (VM). VM has been linked to metastatic TNBC behavior and resistance to anti-angiogenic agents. Epidermal growth factor receptor (EGFR) is frequently expressed on TNBC, but anti-EGFR antibodies have limited efficacy. We synthesized an anti-EGFR antibody-endostatin fusion protein, αEGFR IgG1-huEndo-P125A (αEGFR-E-P125A), designed to deliver a mutant endostatin, huEndo-P125A (E-P125A), to EGFR expressing tumors, and tested its effects on angiogenesis, TNBC VM, and motility in vitro, and on the growth and metastasis of two independent human TNBC xenograft models in vivo
Joel Alter, Moshe Dessau, Meital Gal-Tanamy: Lower Serologic Response to COVID-19 mRNA Vaccine in Patients with Inflammatory Bowel Diseases Treated with Anti-TNFα (Gastroenterology .)
Patients with inflammatory bowel diseases (IBD), specifically those treated with anti-tumor-necrosis-factor (TNF)α biologics are at high risk for vaccine preventable infections. Their ability to mount adequate vaccine responses is unclear. Assesses serologic responses to mRNA-COVID-19 vaccine, and safety profile, in patients with IBD stratified according to therapy, compared to healthy controls (HC).
Einat Levy, Ohad Ronen, Eyal Sela, Eli Layos, Netanel Eisenbach, Nour Ibrahim, Amiel Dror, Amani Daoud, Tal Marshak: Inferior turbinate reduction: Comparing postoperative bleeding between different surgical techniques (J Laryngol Otol .)
Postoperative bleeding is one of the most common and severe complications of turbinate surgery. We conducted a study comparing postoperative bleeding from partial turbinectomy(PT), submucosal turbinate reduction(SmrT), and endoscopic turbinoplasty(EnT).
Adam Sagir: In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19 (Int J Cardiol .)
Endothelial dysfunction is one of the underlying mechanisms to vascular and cardiac complications in patients with COVID-19. We sought to investigate the systemic vascular endothelial function and its temporal changes in COVID-19 patients from a non-invasive approach with reactive hyperemia peripheral arterial tonometry (PAT).
Rola Khamisy-Farah: Fertility-Sparing Treatment of Patients with Endometrial Cancer: A Review of the Literature (J Clin Med . )
Endometrial cancer (EC) is currently the most common malignancy of the female genital tract in developed countries. Although it is more common in postmenopausal women, it may affect up to 25% in the premenopausal age and 3-5% under the age of 40 years. Furthermore, in the last decades a significant shift to pregnancy at older maternal ages, particularly in resource-rich countries, has been observed. Therefore, in this scenario fertility-sparing alternatives should be discussed with patients affected by EC. This study summarizes available literature on fertility-sparing management of patients affected by EC, focusing on the oncologic and reproductive outcomes.
Khalaf Kridin: Retrospective analysis of the clinical characteristics and patient-reported outcomes in vulval lichen planus: Results from a single-center study (J Dermatol .)
Vulval lichen planus (VLP) is a rare, but often chronic, inflammatory disease whose symptoms include genital pain, discomfort, and dyspareunia. The clinical manifestations include erythema, erosions, and scarring. The aim of this study was to longitudinally investigate patient-reported outcomes and clinical findings in patients with VLP.
Daniel Glikman, Eric S Shinwell: Vaccinating children and adolescents against severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), updated data from Israel (Acta Paediatr .)
We read with interest the Letter by Verd et al. commenting on our Editorial regarding vaccination of children and adolescent against severe acute respiratory syndrome corona virus 2 (SARS-CoV-2).1,2 Indeed, when deciding on vaccination policy against SARS-CoV-2 many considerations need to be examined, including the safety of vaccines, the effectiveness in preventing illness (mainly severe), the impact on transmission of the virus, and effect of vaccination on disease prevention at the community and country level.
Offer Amir: In Search of Clinical Impact: Advanced Monitoring Technologies in Daily Heart Failure Care (J Clin Med . )
Despite significant advances in the management of heart failure (HF), further improvement in the outcome of this chronic and progressive disease is still considered a major unmet need.... This manuscript will review the rationale for monitoring HF patients and discuss previous and ongoing attempts to develop clinically meaningful monitoring devices to improve daily HF health care, with particular emphasis on the recent advances and clinical trials relevant to this evolving field.
Jacob Bornstein: Vulvar High-Grade Squamous Intraepithelial Lesions and Cancer as a Risk Factor for Anal Cancer: A Review (J Low Genit Tract Dis .)
Anal squamous cell carcinoma (ASCC) has a higher incidence described in certain groups, namely, in women with vulvar high-grade squamous intraepithelial lesions (vHSILs) and/or human papillomavirus squamous cell carcinoma (VSCC). This review describes terminology, vHSIL, and VSCC in their association with ASCC and the published recommendations for early detection of this cancer in these women.
Khalaf Kridin, Erez Onn: Risk of COVID-19 and its complications in patients with atopic dermatitis undergoing dupilumab treatment-a population-based cohort study (Immunol Res . )
The risk of coronavirus disease (COVID-19) infection and its complications among patients with atopic dermatitis (AD) treated by dupilumab is yet to be determined. We aimed to assess the risk of SARS-CoV-2 infection, COVID-19-associated hospitalization, and mortality among patients with AD treated by dupilumab.