Recent Publications
Limor Meoded Danon: Temporal sociomedical approaches to intersex* bodies (Hist Philos Life Sci .)
The history of the field of intersex bodies/bodies with variations of sex development (VSD) reflects the ongoing tension between sociomedical attempts to control uncertainty and reduce the duration of corporeal uncertainty by means of early diagnosis and treatment, and the embodied subjects who resist or challenge these attempts, which ultimately increase uncertainty. Based on various qualitative studies in the field of intersex, this article describes three temporal sociomedical approaches that have evolved over the last decade and aims to address the uncertainty surrounding intersex/VSD bodies.
Correction: https://link.springer.com/article/10.1007/s40656-022-00517-8
Evgeni Kukuev, Evgeny Belugin, Dafna Willner, Ohad Ronen: Parameters of high-frequency jet ventilation using a mechanical lung model (J Med Eng Technol .)
High frequency jet ventilationis a mechanical lung ventilation method which uses a relatively high flow usually through an open system. This work examined the effect of high-frequency jet ventilation on respiratory parameters of an intubated patient simulated using a high-frequency jet ventilator attached to a ventilation monitor for measurements of ventilation parameters.
Sunanda Biswas Mukherjee, Sumit Mukherjee, Milana Frenkel-Morgenstern: Fusion proteins mediate alternation of protein interaction networks in cancers (Adv Protein Chem Struct Biol . )
Fusions of two different genes could lead to the production of chimeric RNAs, which could be translated into novel fusion (or chimeric) proteins....Here, we discuss the structural features of fusion proteins and how they impact the PPI networks in cancers. Further, we discuss how to analyze the fusion protein-mediated alternation of PPI networks in cancers.
Amir Mari, Aiman Gahshan, Helal Saied Ahmad, Tawfik Khoury: Comparison in Adherence to Treatment between Patients with Mild-Moderate and Severe Reflux Esophagitis: A Prospective Study (J Clin Med . )
Gastro-esophageal reflux disease (GERD) is prevalent and causes erosive esophagitis (EE) with varying degrees of severity (A to D according to the Los Angeles Classification). Adherence to medical therapy is crucial for treatment success. We compared adherence to treatment recommendations between patients with EE grades C/D and A/B.
Andrei Braester: Enoxaparin versus dalteparin or tinzaparin in patients with cancer and venous thromboembolism: The RIETECAT study (Res Pract Thromb Haemost . )
Venous thromboembolism (VTE) is a frequent complication in patients with cancer and a leading cause of morbidity and death. The objective of the RIETECAT study was to compare the long-term effectiveness and safety of enoxaparin versus dalteparin or tinzaparin for the secondary prevention of VTE in adults with active cancer.
Ran Tur-Kaspa: Longitudinal kinetics of RBD+ antibodies in COVID-19 recovered patients over 14 months (PLoS Pathog .)
We describe the longitudinal kinetics of the serological response in COVID-19 recovered patients over a period of 14 months.
Tal Shachar: Medical Students' Knowledge of Plastic Surgery as a Reflection of the Public Perception (Semin Plast Surg .)
Plastic surgery is a broad field that requires a mixed skillset. Therefore, it is important that students be exposed to all its various subspecialties to make informed career decisions and to properly refer patients in different clinical situations. A nationwide survey was conducted of Israeli medical students to investigate their knowledge and perceptions regarding the field of plastic surgery and its subspecialties, and the impact of a clinical rotation in plastic surgery on these factors.
Hanan Rohana, Avi Peretz: High throughput optical modulation biosensing for highly sensitive and rapid detection of biomarkers (Talanta .)
Rapid, highly sensitive, and high-throughput detection of biomarkers at low concentrations is invaluable for early diagnosis of various diseases. In many highly sensitive immunoassays, magnetic beads are used to capture fluorescently labeled target molecules. The target molecules are then quantified by detecting the fluorescent signal from individual beads, which is time consuming and requires a complicated and expensive detection system. Here, we demonstrate a high-throughput optical modulation biosensing (ht-OMB) system, which uses a small permanent magnet to aggregate the beads into a small detection volume and eliminates background noise by steering a laser beam in and out of the cluster of beads.
George Habib: Effect of intramuscular depot betamethasone injection in patients with fibromyalgia and elevated C-reactive protein levels J Investig Med . )
Fibromyalgia is characterized by diffuse musculoskeletal pain and fatigue. There are limited data about systemic steroid treatment of patients with fibromyalgia in the English literature. Patients with fibromyalgia with ongoing diffuse musculoskeletal pain despite standard treatment, extreme fatigue and elevated C-reactive protein (CRP) levels without evidence of synovitis, or other source of inflammation, were asked to participate in our study.
Chaim Putterman: Choroid plexus-infiltrating T cells drive murine neuropsychiatric lupus (Arthritis Rheumatol .)
T cells are critical in the pathogenesis of systemic lupus erythematosus (SLE) by secreting inflammatory cytokines, helping autoantibody production, and forming autoreactive memory T cells. Previous studies have demonstrated their contributions in several forms of organ-mediated damage in SLE, but the role of T cells in neuropsychiatric lupus, the diffuse central nervous system manifestations observed in 20-40% of SLE patients, is not known. Therefore, we evaluated how behavioral deficits are altered upon depletion or transfer of T cells to directly assess the role of T cells in neuropsychiatric systemic lupus erythematosus (NPSLE).
Elon Glassberg: Does cognitive loading interfere with walking control? (Gait Posture .)
Cognitive-motor interference is a common method used to investigate the cognitive demands of human walking. Using this methodology, consistent effects emerge: under cognitive load, walking velocity decreases, while spatio-temporal variability of walking increases. These effects are often interpreted as indicative of an interference in the ability to control gait. However, walking velocity is highly correlated with most gait parameters; thus, the increase in variability does not necessarily reflect reduced control, but rather a constant signal-to-noise ratio. To investigate the effect of cognitive loading on gait variability, we retrospectively analysed 3721 records of healthy young adults, walking with and without a concurrent cognitive task, on a treadmill.
Shlomo Merchavy: Pembrolizumab as a first line therapy in a patient with extensive mucoepidermoid salivary gland carcinoma. A complete clinical, radiological and pathological response. A very specific case (Discov Oncol .)
Patients with advanced salivary gland malignancies (SGCs) have few therapy options. Although results from newly published trials suggest that checkpoint inhibition may be useful in a subgroup of patients, there are no clear criteria for PD-L1 score in SGCs. Chemotherapy benefits were observed to be limited, with a dismal prognosis in unresectable and high-grade SGC. Immunotherapies have demonstrated extraordinary efficacy in a variety of cancers, including non-small cell lung cancer and malignant melanoma. Anti-PD-1 antibody pembrolizumab has been shown to have potent anti-tumor action in a number of clinical trials. We report a unique case of advanced high grade mucoepidermoid carcinoma of the parotid salivary gland after Pembrolizumab treatment as a first line therapy.
Shulamit Fluss Ben-Uliel, Faten Habrat Zoabi, Hadas Sibony-Benyamini, Nir Qvit: De Novo Development of Mitochondria-Targeted Molecular Probes Targeting Pink1 (Int J Mol Sci .)
Mitochondria play central roles in maintaining cellular metabolic homeostasis, cell survival and cell death, and generate most of the cell's energy. Mitochondria maintain their homeostasis by dynamic (fission and fusion) and quality control mechanisms, including mitophagy, the removal of damaged mitochondria that is mediated mainly by the Pink1/Parkin pathway. Pink1 is a serine/threonine kinase which regulates mitochondrial function, hitherto many molecular mechanisms underlying Pink1 activity in mitochondrial homeostasis and cell fate remain unknown. Peptides are vital biological mediators that demonstrate remarkable potency, selectivity, and low toxicity, yet they have two major limitations, low oral bioavailability and poor stability. Herein, we rationally designed a linear peptide that targets Pink1 and, using straightforward chemistry, we developed molecular probes with drug-like properties to further characterize Pink1