Recent Publications
Adnan Zaina: How to position sodium-glucose co-transporter 2 inhibitors in the management of diabetes in acromegaly patients (Endocrine .)
Diabetes mellitus (DM) represents one of the most common metabolic comorbidities and is present in 30% to 40% of patients with acromegaly. This rate is expected to increase further along with the prevalence of DM Patients with acromegaly develop insulin resistance due to excess growth hormone (GH), and insulin insufficiency may occur in those with longstanding disease. Moreover, second-generation somatostatin receptor ligands (SRLs) also contribute to the increased development of new-onset diabetes and worsening hyperglycemia. Worthy of mentioning that patients with acromegaly are at increased risk for cardiomyopathy, heart failure, and atherosclerotic cardiovascular disease (ASCVD), and the coexistence of diabetes might even worsen these conditions.
Offer Amir, Shemy Carasso: Outcomes of Acute Coronary Syndrome Patients Who Presented with Cardiogenic Shock versus Patients Who Developed Cardiogenic Shock during Hospitalization (J Clin Med . )
Cardiogenic shock (CS) continues to be a severe and fatal complication of acute coronary syndrome (ACS). CS patients have a high mortality rate despite significant progress in primary reperfusion, the management of heart failure and the expansion of mechanical circulatory support strategies. The present study addressed the clinical characteristics, management, and outcomes of ACS patients complicated with CS.
Boris Fichtman, Amnon Harel: The Effect of Outer Space and Other Environmental Cues on Bacterial Conjugation (Microbiol Spectr .)
Bacterial conjugation is one of the most abundant horizontal gene transfer (HGT) mechanisms, playing a fundamental role in prokaryote evolution. A better understanding of bacterial conjugation and its cross talk with the environment is needed for a more complete understanding of HGT mechanisms and to fight the dissemination of malicious genes between bacteria. Here, we studied the effect of outer space, microgravity, and additional key environmental cues on transfer (tra) gene expression and conjugation efficiency, using the under studied broad-host range plasmid pN3, as a model.
Enav Yefet, Liron Bar, Johnny S Younis: Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis (Nutrients .)
Objectives: To assess the effects of probiotic supplements on glycemic control and metabolic parameters in women with gestational diabetes mellitus (GDM) by performing a systematic review and meta-analysis of randomized controlled trials. The primary outcome was glycemic control, i.e., serum glucose and insulin levels. Secondary outcomes were maternal weight gain, neonatal birth weight, and lipid parameters. Weighted mean difference (WMD) was used. Cochrane's Q test of heterogeneity and I2 were used to assess heterogeneity.
Raneen Abu Shqara, Yara Nakhleh Francis, Habib Haj, Sofya Markdorf, Lior Lowenstein, Maya Frank Wolf : Digital versus speculum-guided catheter balloon insertion for cervical ripening in multiparas: A randomized controlled trial (Am J Obstet Gynecol MFM .
Catheter balloon insertion into the maternal uterine cervix is routinely speculum-guided; digital-insertion has been reported, although it was not found to be more tolerable in nulliparas. Objective: In multiparas, we aimed to evaluate maternal pain, the induction to delivery interval, and maternal satisfaction of the digital-insertion vs. speculum-guided Foley catheter balloon for labor induction.
Khalaf Kridin:S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV) (J Eur Acad Dermatol Venereol .)
Paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare autoimmune disease with mucocutaneous and multi-organ involvement. PNP/PAMS is typically associated with lymphoproliferative or haematological malignancies, and less frequently with solid malignancies. The mortality rate of PNP/PAMS is elevated owing to the increased risk of severe infections and disease-associated complications, such as bronchiolitis obliterans. Objectives: These guidelines summarize evidence-based and expert-based recommendations (S2k level) for the clinical characterization, diagnosis and management of PNP/PAMS. They have been initiated by the Task Force Autoimmune Blistering Diseases of the European Academy of Dermatology and Venereology with the contribution of physicians from all relevant disciplines. The degree of consent among all task force members was included.
Samih Badarny, Amal Abu Ayash, Galina Keigler: Vagal Nerve Activity and Short-Term Clinical Outcomes after Stroke: What Is Left May Not Be Right (J Clin Med .)
Stroke is a leading cause of death worldwide. Multiple factors influence the severity of stroke. Normal functional and biological differences seen between the hemispheres may also be related to stroke severity. In the present study, we examined the differences in the severity of stroke as a function of stroke side, and whether patients' vagal nerve activity moderated such differences.
Shira Perez, Anat Lavi-Itzkovitz, Tom Domovitz, Roba Dabour, Meital Gal-Tanamy: High-resolution genomic profiling of liver cancer links etiology with mutation and epigenetic signatures (Cell Mol Gastroenterol Hepatol . )
Hepatocellular carcinoma (HCC) is a model of diverse spectrum of cancers, since it is induced by well-known etiologies, mainly Hepatitis C virus (HCV) and Hepatitis B virus (HBV). Here we aimed to identify HCV-specific mutational signature and explored the link between the HCV-related regional variation in mutations rates and HCV-induced alterations in genome-wide chromatin organization.
Jacob Bornstein: Consensus statement on the management of vaginal intraepithelial neoplasia
Full name of article: The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia
The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for patients with vaginal intraepithelial neoplasia (VaIN).
Amir Kuperman, Tzipora C Falik Zaccai: The Clinical Picture of the ERCC6L2 Disease - from Bone Marrow Failure to Acute Leukemia (Blood . )
Biallelic germline ERCC6L2 variants strongly predispose to bone marrow failure (BMF) and myeloid malignancies characterized by somatic TP53-mutated clones and erythroid predominance. We present a series of 52 subjects (35 families) with ERCC6L2 biallelic germline variants collected retrospectively in 11 centers globally, including follow-up of 1165 person-years.
Edo Y Birati: Durable Left Ventricular Assist Device Outflow Graft Obstructions: Clinical Characteristics and Outcomes (J Clin Med . )
We report on the clinical course and management of patients supported with durable implantable LVADs who developed outflow graft obstructions at a large academic center.
Ala Aiob, Raneen Abu Shqara, Susana Mustafa Mikhail, Avishalom Sharon, Marwan Odeh, Lior Lowenstein: Alternative beta-hCG follow-up protocols after single-dose methotrexate therapy for ectopic pregnancy: A retrospective cohort study (Eur J Obstet Gynecol
This study assessed the relevance of reductions in beta-hCG levels between days 0 and 4 and between days 0 and 7 after single-dose methotrexate therapy, and the success of the therapy.
Nasser Sakran: Nutritional and Lifestyle Behaviors Reported Following One Anastomosis Gastric Bypass Based on a Multicenter Study (Nutrients .)
This study aimed to describe nutritional and lifestyle parameters following one-anastomosis gastric bypass (OAGB).
Liza Grosman-Rimon, Muhamd Atrash, Aida Nakhoul, Hanadi Saadi, Edo Y Birati, Shemy Carasso, Erez Kachel: The Effects of Preoperative Pain Education on Pain Severity in Cardiac Surgery Patients: A Pilot Randomized Control Trial (Pain Manag Nurs .)
There is minimal research on the effect of individualized preoperative education on postoperative pain and postoperative pain medication intake. The study objective was to assess the effect of individually tailored preoperative education on postoperative pain severity, number of pain breakthroughs, and use of pain medication in participants receiving the intervention compared to controls.
Mulate Zerihun, Surya Sukumaran, Nir Qvit: The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy (Int J Mol Sci .)
Mitochondria, the membrane-bound cell organelles that supply most of the energy needed for cell function, are highly regulated, dynamic organelles bearing the ability to alter both form and functionality rapidly to maintain normal physiological events and challenge stress to the cell. This amazingly vibrant movement and distribution of mitochondria within cells is controlled by the highly coordinated interplay between mitochondrial dynamic processes and fission and fusion events, as well as mitochondrial quality-control processes, mainly mitochondrial autophagy (also known as mitophagy). ... In this review, we first aim to describe the structural elements, functionality, and regulatory mechanisms of the key mitochondrial fission protein, Drp1, and other mitochondrial fission adaptor proteins, including mitochondrial fission 1 (Fis1), mitochondrial fission factor (Mff), mitochondrial dynamics 49 (Mid49), and mitochondrial dynamics 51 (Mid51). The core area of the review focuses on the recent advances in understanding the role of the Drp1-mediated mitochondrial fission adaptor protein interactome to unravel the missing links of mitochondrial fission events. Lastly, we discuss the promising mitochondria-targeted therapeutic approaches that involve fission, as well as current evidence on Drp1-mediated fission protein interactions and their critical roles in the pathogeneses of cardiovascular diseases (CVDs).