Recent Publications
Lilach Malatskey, Jumanah Essa-Hadad, Reut Eldar, Inna Filipov, Sophia Eilat-Tsanani, Mary C J Rudolf: Medical student lifestyle counselling for non-communicable disease: impact on students' competence and patients' health behaviors (Isr J Health Policy R
Promoting healthy lifestyle is key to tackling lifestyle-induced diseases, yet many doctors feel unskilled and medical schools lack its inclusion in their curricula. The impact of a novel elective lifestyle course is described, where students provided 3 months' coaching to at-risk patients.
Shaul Atar: Peripheral Arterial Disease in Patients With Acute Coronary Syndrome: Results From a Large Real-World Registry (Heart Lung Circ .)
Limited data exist regarding the significance of peripheral arterial disease (PAD) in patients with acute coronary syndrome (ACS). We evaluated 16,922 consecutive ACS patients who were prospectively included in a national ACS registry. The co-primary endpoint included 30 days major adverse cardiovascular event (MACE) (re-infarction, stroke, and/or cardiovascular death) and 1-year mortality.
Hiba Zayyad: Hospitalised patients with breakthrough COVID-19 following vaccination during two distinct waves in Israel, January to August 2021: a multicentre comparative cohort study (Euro Surveill .)
Changing patterns of vaccine breakthrough can clarify vaccine effectiveness. Compares breakthrough infections during a SARS-CoV-2 Delta wave vs unvaccinated inpatients, and an earlier Alpha wave.
Offer Amir: Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (The SilHF study): A randomised placebo-controlled multicentre trial (Eur J Heart Fail .)
Pulmonary hypertension (PHT) may complicate heart failure with reduced ejection fraction (HFrEF) and is associated with a substantial symptom burden and poor prognosis. Sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, might have beneficial effects on pulmonary haemodynamics, cardiac function and exercise capacity in HFrEF and PHT. Determines the safety, tolerability, and efficacy of sildenafil in patients with HFrEF and indirect evidence of PHT.
Anton Ouryvaev, Anca Leibovici, Luiza Akria, Dimitry Goncharov, Neomi Mativ, Avia Kauffman, Ayelet Shai: The Effectiveness and Safety of Medical Cannabis for Treating Cancer Related Symptoms in Oncology Patients (Front Pain Res (Lausanne) .)
The use of medical cannabis (MC) to treat cancer-related symptoms is rising. However, there is a lack of long-term trials to assess the benefits and safety of MC treatment in this population. In this work, we followed up prospectively and longitudinally on the effectiveness and safety of MC treatment.
Amir Mari: Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management (J Clin Med .)
Symptoms related to abnormalities in gastrointestinal tract motility and functions are very common in the general population, affecting both pediatrics and adults, from both sexes [...]. Editorial
Offer Amir: Changes in voice patterns for monitoring heart failure deterioration (EuroIntervention . )
Heart failure (HF) affects >6 million adults in the United States1 and 26 million worldwide2, at a cost of over $30 billion in the United States alone3. Pulmonary congestion is the predominant factor leading to hospitalisation for HF patients, and also is a major contributor to poor outcomes after hospital discharge. A need exists for a simple, non-invasive approach to detecting worsening pulmonary congestion at an early stage for the management of HF patients. In the context of pulmonary congestion, it has been proposed that the fluid overload may be detected by distinctly altered phonation patterns.
Elias Hellou, Ameer Elemy, Fahed Hakim: Effect of ArtemiC in patients with COVID-19: A Phase II prospective study (J Cell Mol Med . )
Despite intensive efforts, there is no effective remedy for COVID-19. Moreover, vaccination efficacy declines over time and may be compromised against new SARS-CoV-2 lineages. Therefore, there remains an unmet need for simple, accessible, low-cost and effective pharmacological anti-SARS-CoV-2 agents. ArtemiC is a medical product comprising artemisinin, curcumin, frankincense and vitamin C, all of which possess anti-inflammatory and anti-oxidant properties. The present Phase II placebo-controlled, double-blinded, multi-centred, prospective study evaluated the efficacy and safety of ArtemiC in patients with COVID-19.
Roie Fisher, Ohad Ronen: Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis (Head Neck . )
It is important to define the accuracy of fine-needle aspiration cytology (FNAC) in the diagnosis of Warthin tumor (WT). This systematic review and meta-analysis evaluated the accuracy of FNAC in the diagnosis of WT in the parotid gland and WT growth rate.
A Novel Homozygous Missense Variant in the LRRC32 Gene Is Associated With a New Syndrome of Cleft Palate, Progressive Vitreoretinopathy, Growth Retardation, and Developmental Delay (Front Pediatr . )
Cleft lip and/or cleft palate are a common group of birth defects that further classify into syndromic and non-syndromic forms. The syndromic forms are usually accompanied by additional physical or cognitive abnormalities. Isolated cleft palate syndromes are less common; however, they are associated with a variety of congenital malformations and generally have an underlying genetic etiology. A single report in 2019 described a novel syndrome in three individuals, characterized by cleft palate, developmental delay and proliferative retinopathy due to a homozygous non-sense mutation in the LRRC32 gene encoding glycoprotein A repetitions predominant (GARP), a cell surface polypeptide crucial for the processing and maturation of transforming growth factor β (TGF-β). We describe a patient who presented with cleft palate, prenatal and postnatal severe growth retardation, global developmental delay, dysmorphic facial features and progressive vitreoretinopathy.
(Boris Fichtman, Haneen Jabaly-Habib, Lee S Izhaki-Tavor, Moshe Dessau)
Daniel Moreinos: Tooth Resorption - Part 1: The evolvement, rationales and controversies of tooth resorption (Dent Traumatol .)
In 1966, Andreasen and Hjørting-Hansen were the first to describe a relationship between tooth resorption and dental trauma. However, Andreasen's original classification did not include other resorptive processes which have since been identified. Numerous articles have been published suggesting new terminology and definitions for tooth resorption. A uniform language with universally accepted terminology is crucial to eliminate the multiplicity of terms and definitions which only cause confusion within the profession. An electronic literature search was carried out in the PubMed database using the following keywords for articles published in English: "root resorption," "inflammatory root resorption," "replacement resorption," "cervical resorption," "trauma," "ankylosis," "surface resorption," and "internal resorption." The search also included textbooks and glossaries that may not have surfaced in the online search. This was done to identify articles related to tooth resorption and its etiology in dentistry. The aim of this review was to present the history that has led to the variety of terms and definitions for resorption.
Inass Kayyal-Tarabeia, Michael Blank, Keren Agay-Shay: "Residential greenness and site-specific cancer: A registry based cohort of 144,427 participants with a 21-years of follow-up, Tel-Aviv district, Israel" (Environ Res . )
Few longitudinal studies evaluated the beneficial associations between cumulative residential greenness and site-specific cancer. Our objective was to evaluate the associations between cumulative residential greenness exposure and site-specific cancer incidence (lung, bladder, breast, prostate, and skin cancer) within a registry-based cohort study.
Keren Pevzner: Evolution of the Septal Extension Graft in Endonasal Rhinoplasty: Long-Term Efficacy and Reliability (Aesthet Surg J .)
Proper nasal tip projection and rotation have a strong impact on nasal aesthetics. Septal extension graft is one of the tools used to improve tip projection and rotation when performing rhinoplasty. This graft typically overlaps the existing caudal septum in the midline position, lengthening it and facilitating the repositioning of the tip. Describes the technical evolution of the septal extension graft in endonasal rhinoplasty and evaluate the reliability and long-term efficacy of the current technique.
Michael Carmiel: Safety and Effectiveness Using 8 Weeks of Glecaprevir/Pibrentasvir in HCV-Infected Treatment-Naïve Patients with Compensated Cirrhosis: The CREST Study (Adv Ther .)
In clinical trials with hepatitis C virus-infected treatment-naïve (TN) patients with compensated cirrhosis (CC), glecaprevir/pibrentasvir (G/P), a fixed-dose, once-daily, pangenotypic regimen, has demonstrated sustained virologic response at posttreatment Week 12 (SVR12) > 95%. We evaluated the real-world safety and effectiveness of 8-week G/P therapy in TN patients with CC, including certain subgroups of interest.
Alon Barash: On the job training in the dissection room: from physical therapy graduates to junior anatomy instructors (BMC Med Educ . )
The training of near-peer (NP) teachers and junior faculty instructors received major attention as a possible solution for the shortage of experienced anatomy instructors in faculties of medicine and health professions. Several studies described the training of NP teachers and junior instructors (≤ 2 years of teaching experience) using various methods. However, few publications include On the Job Training (OJT), which enables reflection and performance evaluation and encourages professionals to cope with their blind spots. Previous publications describing OJT did not include formal observation of the NP teacher or junior instructor. Therefore, this study aimed to present a novel approach to OJT inclusion during prosection laboratories based on the Lewinian experiential model.