Inbar Ben-Zvi, David Karasik: Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies (Curr Osteoporos Rep .)

GWAS, as a largely correlational analysis, requires in vitro or in vivo validation. Zebrafish (Danio rerio) have many advantages for studying the genetics of human diseases. Since gene editing in zebrafish has been highly valuable for studying embryonic skeletal developmental processes that are prenatally or perinatally lethal in mammalian models, we are reviewing pros and cons of this model.