Zaher Armaly: Glycocalyx degradation in ischemia-reperfusion injury (Am J Pathol.)

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glycocalyx wikipedia

The glycocalyx is a layer coating the luminal surface of vascular endothelial cells. It is vital for endothelial function as it participates in microvascular reactivity, endothelium interaction with blood constituents, and vascular permeability. Structural and functional damage to glycocalyx occurs in various disease states....This review focuses on alterations of glycocalyx during I/R injury in general and to vital organs in particular, and on maneuvers aimed at glycocalyx recovery during I/R injury.