From Doctoral Student to Doctor (finishing his doctorate at Prof. Evan Elliott's lab)

Ram Harari

My academic journey began with a bachelor's degree in Life Sciences at Tel-Hai College, which I chose because of my extensive background in animal agriculture. During my undergraduate studies, I was introduced to the field of molecular biology, which fascinated me deeply, and I realized that I wanted to continue exploring it further.

This led me to pursue a master's degree in the lab of Prof. David Karasik at the Azrieli Faculty of Medicine at Bar-Ilan University, where I studied the molecular mechanisms of bone diseases using zebrafish models. Throughout my MSc, I discovered the field of medical science and biomedical research—an area I hadn’t been previously familiar with due to my agricultural background. I found it incredibly compelling and knew I wanted to continue in this direction.

The experience I gained working with zebrafish during my MSc allowed me to work as a research assistant in Dr. Karen Jackson’s lab for preclinical research using zebrafish at the MIGAL Research Institute. The lab focused on investigating the effects of various cannabis extracts as treatments for neurological disorders. During my two years there, I was introduced to the field of behavioral neurology and the impact of psychoactive substances on consciousness. It became clear to me that this was a topic I was passionate about and wanted to explore further. I concluded that pursuing a PhD would be the best way to continue researching this area.

I approached Prof. Evan Elliott at the Faculty of Medicine at Bar-Ilan University to inquire about doctoral studies in his lab for molecular and behavioral neurobiology. When he offered me the opportunity to research the psychoactive compound psilocybin, I immediately agreed—it encompassed everything that intrigued me. And so, I returned to the Faculty to begin my PhD studies.

My doctoral research focused on the effects of psilocybin, a psychoactive compound found in psychedelic mushrooms, which in recent years has shown significant medical potential as a treatment for various neurological and psychological disorders, including clinical depression and PTSD. However, alongside its potential benefits, psilocybin also induces acute anxiety, which currently limits its use as a therapeutic drug.

In my research, we demonstrated that psilocybin indeed causes acute anxiety in mice, and that this operates through a mechanism different from what had previously been understood. Additionally, in another study, we found that psilocybin also alters gene expression in the brain in a manner similar to changes caused by light exposure. These findings contribute to advancing the therapeutic use of psilocybin—an especially urgent goal in today’s world.

My PhD journey was marked by many ups and downs, influenced by major events such as the COVID-19 pandemic and the Iron Swords War, which naturally impacted my research. Looking back, it was a highly challenging time, filled with obstacles, but also with immense personal growth and fulfillment.

In summary, I can say that throughout my PhD I experienced significant professional development, but also personal and ethical growth. Through the experience I gained in the lab and at the Faculty, I was able to shape the path I wish to pursue in the world of research.

Looking ahead, I plan to pursue a postdoctoral fellowship abroad and to continue conducting research in the field of neurobiology.

Tip for students: Don’t be afraid to take chances—even when the path isn’t clear. Follow your heart and your curiosity. In the end, it’s worth it.