עברית

Dr. Nir Qvit

מרצה בכיר Senior Lecturer
Telephone
072-264-4849
Bar-Ilan Email
nir.qvit@biu.ac.il
Fields of Interest

Identification of molecular modulators of protein-protein interaction using bioinformatics analysis, peptide and protein chemistry,and system-wide biological assays.

Personal Website
Academic field
Pharmacology
Research field
Chemistry and Biology of Protein-Protein Interactions for Drug Discovery
Research Center
Bar-Ilan University Azrieli Faculty of Medicine, Safed
CV

Dr. Kvit completed his PhD in organic chemistry at the Hebrew University, developing different strategies for the synthesis of small molecules and peptides, in solution and solid base, for various therapeutic applications.

Research

Protein-protein interactions represent a significant proportion of functionally relevant biological interactions, and therefore manipulating these interactions is an important therapeutic strategy. The main focus of the Qvit lab is the identification of molecular modulators of protein-protein interaction using bioinformatics analysis, peptide and protein chemistry, and system-wide biological assays. Our goal is the development of compounds capable of modulating protein complexes that will allow a better understanding of the role of specific protein-protein interactions in cells and will be a starting point for the development of therapeutic compounds.

Courses

Medicinal Chemistry of Drug Discovery
כימיה רפואית של גילוי תרופות

 

Peptide therapeutics
פפטידים ופיתוח תרופות

 

Drug discovery and developments in developing countries
גילוי ופיתוח תרופות במדינות מתפתחות

Publications

הכי מעודכן כאן

Peer-Reviewed Publications

2017

  • Cunningham AD*, Qvit N*,# Mochly-Rosen D# (2017). Peptides and Peptidomimetics as Regulators of Protein-Protein Interactions. Current Opinion in Structural Biology, 44, 59-66. *Equal contribution, #Corresponding authors. Invited article
     
  • Qvit N#, Rubin S, Urban TJ, Mochly-Rosen D, Gross RE (2017). Peptidomimetic Therapeutics: Scientific Approaches and Opportunities. Drug Discovery Today, 22, (2), 454-462. #Corresponding author. Invited article

2016

  • Qvit N#, Kornfeld OS, Mochly-Rosen D# (2016). Engineered Substrate‐Specific Delta PKC Isoform Antagonists to Enhance Cardiac Therapeutics. Angewandte Chemie International Edition, 12, 55(50), 15672 -15679. #Corresponding authors.
  • Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW (2016). Correcting Mitochondrial Fusion Defects by Manipulating Mitofusin Conformation. Nature, 1, 540(7631), 74-79.
  • Qvit N, Disatnik MH, Jie S, Mochly-Rosen D (2016). Selective Phosphorylation Inhibitor of δPKC-PDK Protein-Protein Interactions; Application for Myocardial Injury in Vivo. Journal of the American Chemical Society, 22, 138(24), 7626-7635.
  • Hurt MC, Lu Y, Stary C, Piplani H, Small AB, Urban JT, Qvit N, Gross JG, Mochly-Rosen D, Gross RE (2016). Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial 2 Membrane Potential and Myocardial Reperfusion Injury. Journal of the American Heart Association, 26, 5(9), e003774, 1-13.
  • Qvit N#, Joshi AU, Cunningham AD, Ferreira CBJ, Mochly-Rosen D# (2016). GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death. Journal of Biological Chemistry, 24, 291(26), 13608-13621. #Corresponding authors.
  • Qvit N#, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang AL, Baron LA, Teh-Poot C, Martínez-Vega P, Remirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, Gozzo FC, Torrecilhas AC, Alves MJM, Jardim A, Momar N, Dumonteil E, Mochly-Rosen D (2016). Scaffold Proteins LACK and TRACK as Potential Drug Targets in Kinetoplastid Parasites: Development of Inhibitors. International Journal for Parasitology: Drugs and Drug Resistance, 6, 74-84. #Corresponding author.
  • Qvit N#, Kornfeld OS (2016). Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation. Journal of Visualized Experiments, 107, e53589, 1-14. #Corresponding author. Invited article
  • Cunningham AD*, Qvit N*,# (2016). Specific Kinase Inhibition Using Peptides to Target Kinase-Substrate Docking. Chimica Oggi/Chemistry Today, 34(5), 16, 22-25. *Equal contribution, #Corresponding author. Invited article
  • Rubin S*, Qvit N*,# (2016). Cyclic Peptides for Protein-Protein Interaction Targets: Applications to Human Disease. Critical Reviews in Eukaryotic Gene Expression, 26(3), 199-221. *Equal contribution, #Corresponding author. Invited article
  • Featured on the front cover

2015

  • Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D (2015). Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases. Circulation Research, 116(11), 1783-1799. Invited article

2014

  • Qvit N# (2014). Microwave Assisted Synthesis of Cyclic Phosphopeptides on Solid Support. Chemical Biology and Drug Design, 85(3), 300-305. #Corresponding author.
  • Qvit N#, Crapster JA (2014). Peptides that Target Protein-Protein Interactions as an Anti-Parasite Strategy. Chimica Oggi/Chemistry Today, 32(6), 62-66. #Corresponding author. Invited article
  • Qvit N, Mochly-Rosen D (2014). The Many Hats of Delta Protein Kinase C; One Enzyme with Many Functions. Biochemical Society Transactions, 42(6), 1529-1533. Invited article
  • Qvit N, Disatnik MH, Mochly-Rosen D (2014). Engineering a Delta Protein Kinase C Inhibitor that Selectively Inhibits Interaction and Phosphorylation of One Substrate of the Multi-Substrate Kinase. The FASEB Journal, 28, 1.

2013

  • Qi X*, Qvit N*, Su YC, Mochly-Rosen D (2013). A Novel Drp1 Inhibitor Diminishes Aberrant Mitochondrial Fission and Neurotoxicity. Journal of Cell Science, 126(Pt 3), 789-802. *Equal contribution.
  • This article was mentioned as a future direction in a review about mitochondrial dynamics. Archer, S. L. (2013).  Mitochondrial Dynamics-Mitochondrial Fission and Fusion in Human Diseases. New England Journal of Medicine, 369, 2236.

2012

  • Qvit N, Disatnik MH, Mochly-Rosen D (2012). Novel Selective Peptide Regulator of Protein Kinase C Based on Rational Approach Design. Biosensors and Bioelectronics, 2, 142.

2011

  • Qvit N# (2011). Development and Therapeutics Applications of Oligonucleotides and Peptides. Chimica Oggi/Chemistry Today, 29(2), 16, 4-7. #Corresponding author. Invited article

2010

  • Qvit N, Mochly-Rosen D (2010). Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. Drug Discovery Today: Disease Mechanisms, 7(2), e87-e93. Invited article
  • Mochly-Rosen D, Qvit N (2010). Peptide Inhibitors of Protein-Protein Interactions: From Rational Design to the Clinic. Chimica Oggi/Chemistry Today, 28(1), 14-16. Invited article

2009

  • Qvit N, Hatzubai A, Shalev ED, Ben-Neriah Y, Gilon C (2009). Design and Synthesis of Backbone Cyclic Phosphorylated Peptides: The I Kappa B Model. Biopolymers, 91(2), 157-168.
  • Churchill E*, Qvit N*, Mochly-Rosen D (2009). Rationally Designed Peptide Regulators of Protein Kinase C. Trends in Endocrinology and Metabolism, 20(1), 25-33. *Equal contribution. Invited article
  • Qvit N, Disatnik MH, Mochly-Rosen D (2009). Peptide Regulators of Protein-Protein Interactions with Selectivity for Specific Sub-Cellular Compartments. Biopolymers, 92, 322.
  • Qvit N, Hatzubai A, Shalev ED, Ben-Neriah Y, Gilon C (2009). Design and Synthesis of Backbone Cyclic Phosphopeptides: The IκB Model. Advances in Experimental Medicine and Biology, 611, 139-140.

2008

  • Qvit N#, Monderer-Rothkoff G, Ido A, Shalev ED, Amster-Choder O, Gilon C# (2008). Development of Bifunctional Photoactivatable Benzophenone Probes and their Application to Glycoside Substrates. Biopolymers, 90(4), 526-536. #Corresponding authors.
  • This article was chosen as one of the top 20 articles in the National Library of Medicine's since its publication (MEDLINE database, BioMedLib, http://bmlsearch.com/).
  • Qvit N, Reuveni H, Gazal S, Zundelevich A, Blum G, Niv YM, Feldstein A, Meushar S, Shalev ED, Friedler A, Gilon C (2008). Synthesis of Novel Macrocyclic Library: Discovery of an IGF-1R Inhibitor. Journal of Combinatorial Chemistry, 10(2), 256-266.
  • Nuti F, Qvit N, Rizzolo F, Hurevich M, Carotenuto A, Peroni E, Chelli M, Rovero P, Gilon C, Papini AM  (2008). Microwave-Assisted Solid Phase Synthesis of Backbone Cyclic Glycopeptide Libraries. Journal of Peptide Science, 14, 131.

2007

  • Qvit N, Barda Y, Shalev ED, Gilon C (2007). A Laboratory Preparation of Aspartame Analogs Using Simultaneous Multiple Parallel Synthesis Methodology. Journal of Chemical Education, 84(12), 1988-1991.

2006

  • Qvit N, Gilon C, Amster-Choder O, Monderer-Rothkoff G (2006). Using Novel Benzophenon-Glucosides to Study Microbial Sugar Recognition and Translocation by Photo-Affinity Labeling. Journal of Peptide Science, 12, 84.

2004

  • Qvit N, Reuveni H, Gazal S, Peretzman-Shemer A, Blum G, Niv YM, Feldstein A, Meushar S, Gilon C (2004). Novel Macrocyclic Libraries with Spatial Diversity (SIBs): Application for the Discovery of IGF-1R Inhibitor. Journal of Peptide Science, 10, 95.

 

 

 

Last Updated Date : 09/02/2025