Dr. Nir Qvit

Publications

Peer-Reviewed Publications

2017

• Cunningham AD^*, Qvit N^*,# Mochly-Rosen D^# (2017). Peptides and Peptidomimetics as Regulators of Protein-Protein Interactions. Current Opinion in Structural Biology, 44, 59-66. ^*Equal contribution, ^#Corresponding authors. Invited article
   
• Qvit N^#, Rubin S, Urban TJ, Mochly-Rosen D, Gross RE (2017). Peptidomimetic Therapeutics: Scientific Approaches and Opportunities. Drug Discovery Today, 22, (2), 454-462. ^#Corresponding author. Invited article

2016

• Qvit N^#, Kornfeld OS, Mochly-Rosen D^# (2016). Engineered Substrate‐Specific Delta PKC Isoform Antagonists to Enhance Cardiac Therapeutics. Angewandte Chemie International Edition, 12, 55(50), 15672 -15679. ^#Corresponding authors.
• Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW (2016). Correcting Mitochondrial Fusion Defects by Manipulating Mitofusin Conformation. Nature, 1, 540(7631), 74-79.
• Qvit N, Disatnik MH, Jie S, Mochly-Rosen D (2016). Selective Phosphorylation Inhibitor of δPKC-PDK Protein-Protein Interactions; Application for Myocardial Injury in Vivo. Journal of the American Chemical Society, 22, 138(24), 7626-7635.
• Hurt MC, Lu Y, Stary C, Piplani H, Small AB, Urban JT, Qvit N, Gross JG, Mochly-Rosen D, Gross RE (2016). Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial 2 Membrane Potential and Myocardial Reperfusion Injury. Journal of the American Heart Association, 26, 5(9), e003774, 1-13.
• Qvit N^#, Joshi AU, Cunningham AD, Ferreira CBJ, Mochly-Rosen D^# (2016). GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death. Journal of Biological Chemistry, 24, 291(26), 13608-13621. ^#Corresponding authors.
• Qvit N^#, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang AL, Baron LA, Teh-Poot C, Martínez-Vega P, Remirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, Gozzo FC, Torrecilhas AC, Alves MJM, Jardim A, Momar N, Dumonteil E, Mochly-Rosen D (2016). Scaffold Proteins LACK and TRACK as Potential Drug Targets in Kinetoplastid Parasites: Development of Inhibitors. International Journal for Parasitology: Drugs and Drug Resistance, 6, 74-84. ^#Corresponding author.
• Qvit N^#, Kornfeld OS (2016). Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation. Journal of Visualized Experiments, 107, e53589, 1-14. ^#Corresponding author. Invited article
• Cunningham AD^*, Qvit N^*,# (2016). Specific Kinase Inhibition Using Peptides to Target Kinase-Substrate Docking. Chimica Oggi/Chemistry Today, 34(5), 16, 22-25. ^*Equal contribution, ^#Corresponding author. Invited article
• Rubin S^*, Qvit N^*,# (2016). Cyclic Peptides for Protein-Protein Interaction Targets: Applications to Human Disease. Critical Reviews in Eukaryotic Gene Expression, 26(3), 199-221. ^*Equal contribution, ^#Corresponding author. Invited article
• Featured on the front cover

2015

• Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D (2015). Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases. Circulation Research, 116(11), 1783-1799. Invited article

2014

• Qvit N^# (2014). Microwave Assisted Synthesis of Cyclic Phosphopeptides on Solid Support. Chemical Biology and Drug Design, 85(3), 300-305. ^#Corresponding author.
• Qvit N^#, Crapster JA (2014). Peptides that Target Protein-Protein Interactions as an Anti-Parasite Strategy. Chimica Oggi/Chemistry Today, 32(6), 62-66. ^#Corresponding author. Invited article
• Qvit N, Mochly-Rosen D (2014). The Many Hats of Delta Protein Kinase C; One Enzyme with Many Functions. Biochemical Society Transactions, 42(6), 1529-1533. Invited article
• Qvit N, Disatnik MH, Mochly-Rosen D (2014). Engineering a Delta Protein Kinase C Inhibitor that Selectively Inhibits Interaction and Phosphorylation of One Substrate of the Multi-Substrate Kinase. The FASEB Journal, 28, 1.

2013

• Qi X^*, Qvit N^*, Su YC, Mochly-Rosen D (2013). A Novel Drp1 Inhibitor Diminishes Aberrant Mitochondrial Fission and Neurotoxicity. Journal of Cell Science, 126(Pt 3), 789-802. ^*Equal contribution.
• This article was mentioned as a future direction in a review about mitochondrial dynamics. Archer, S. L. (2013).  Mitochondrial Dynamics-Mitochondrial Fission and Fusion in Human Diseases. New England Journal of Medicine, 369, 2236.

2012

• Qvit N, Disatnik MH, Mochly-Rosen D (2012). Novel Selective Peptide Regulator of Protein Kinase C Based on Rational Approach Design. Biosensors and Bioelectronics, 2, 142.

2011

• Qvit N^#(2011). Development and Therapeutics Applications of Oligonucleotides and Peptides. Chimica Oggi/Chemistry Today, 29(2), 16, 4-7. ^#Corresponding author. Invited article

2010

• Qvit N, Mochly-Rosen D (2010). Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. Drug Discovery Today: Disease Mechanisms, 7(2), e87-e93. Invited article
• Mochly-Rosen D, Qvit N (2010). Peptide Inhibitors of Protein-Protein Interactions: From Rational Design to the Clinic. Chimica Oggi/Chemistry Today, 28(1), 14-16. Invited article

2009

• Qvit N, Hatzubai A, Shalev ED, Ben-Neriah Y, Gilon C (2009). Design and Synthesis of Backbone Cyclic Phosphorylated Peptides: The I Kappa B Model. Biopolymers, 91(2), 157-168.
• Churchill E^*, Qvit N^*, Mochly-Rosen D (2009). Rationally Designed Peptide Regulators of Protein Kinase C. Trends in Endocrinology and Metabolism, 20(1), 25-33. ^*Equal contribution. Invited article
• Qvit N, Disatnik MH, Mochly-Rosen D (2009). Peptide Regulators of Protein-Protein Interactions with Selectivity for Specific Sub-Cellular Compartments. Biopolymers, 92, 322.
• Qvit N, Hatzubai A, Shalev ED, Ben-Neriah Y, Gilon C (2009). Design and Synthesis of Backbone Cyclic Phosphopeptides: The IκB Model. Advances in Experimental Medicine and Biology, 611, 139-140.

2008

• Qvit N^#, Monderer-Rothkoff G, Ido A, Shalev ED, Amster-Choder O, Gilon C^# (2008). Development of Bifunctional Photoactivatable Benzophenone Probes and their Application to Glycoside Substrates. Biopolymers, 90(4), 526-536. ^#Corresponding authors.
• This article was chosen as one of the top 20 articles in the National Library of Medicine's since its publication (MEDLINE database, BioMedLib, http://bmlsearch.com/).
• Qvit N, Reuveni H, Gazal S, Zundelevich A, Blum G, Niv YM, Feldstein A, Meushar S, Shalev ED, Friedler A, Gilon C (2008). Synthesis of Novel Macrocyclic Library: Discovery of an IGF-1R Inhibitor. Journal of Combinatorial Chemistry, 10(2), 256-266.
• Nuti F, Qvit N, Rizzolo F, Hurevich M, Carotenuto A, Peroni E, Chelli M, Rovero P, Gilon C, Papini AM  (2008). Microwave-Assisted Solid Phase Synthesis of Backbone Cyclic Glycopeptide Libraries. Journal of Peptide Science, 14, 131.

2007

• Qvit N, Barda Y, Shalev ED, Gilon C (2007). A Laboratory Preparation of Aspartame Analogs Using Simultaneous Multiple Parallel Synthesis Methodology. Journal of Chemical Education, 84(12), 1988-1991.

2006

• Qvit N, Gilon C, Amster-Choder O, Monderer-Rothkoff G (2006). Using Novel Benzophenon-Glucosides to Study Microbial Sugar Recognition and Translocation by Photo-Affinity Labeling. Journal of Peptide Science, 12, 84.

2004

• Qvit N, Reuveni H, Gazal S, Peretzman-Shemer A, Blum G, Niv YM, Feldstein A, Meushar S, Gilon C (2004). Novel Macrocyclic Libraries with Spatial Diversity (SIBs): Application for the Discovery of IGF-1R Inhibitor. Journal of Peptide Science, 10, 95.