ד"ר ניר קוויט

ד"ר
ד"ר ניר קוויט
טלפון: 
דוא"ל בר-אילן: 
משרד: 
תחום הוראה: 
פרמקולוגיה
תחום מחקר: 
קשרים בין חלבונים
מרכז מחקר: 

קורות חיים

ד"ר קויט סיים את הדוקטורט שלו בכימיה אורגנית בפיתוח אסטרטגיות שונות לסינתזה של מולקולות ופפטידים קטנים, בתמיסה ומצע מוצק, עבור יישומים טיפוליים שונים באוניברסיטה העברית. במחקר שלו התגבר על סינתזה מאתגרת, ופיתח פרוצדורה חדשנית ליצירת מעכבי אינטראקציות בין חלבונים. ד"ר קוויט זכה בפרס היוקרתי Kaye Innovation Award כאשר הפגין יצירתיות יוצאת דופן ככימאי מדיסינאלי   .medicinal chemist

בשנת 2008 הצטרף ד"ר קויט למחלקה Chemical and System Biology בבית הספר לרפואה באוניברסיטת סטנפורד. בסטנפורד התמקד בפיתוח כלים חדשים לוויסות אינטראקציות בין חלבונים. הוא היה המדען הראשון לפתח מעכב, אשר באופן סלקטיבי וויסת אינטראקציות בין קינאז לבין סובסרט אחד מתוך סובסרטים רבים.  כמו כן, הוא פיתח מעכב ספציפי של GTPase גדול, כדי לווסת את ביקוע המיטוכונדריה המוגזמת. מעכב זה פעיל מאוד במודלים של מחלות נוירודגנרטיביות. טכנולוגיה זו קיבלה רישיון לחברת ביופרמצבטיקה בישראל.
ד"ר קויט כיהן כיו"ר כנס במספר כנסים שונים, והיושב ראש הראשון של הכנס
“Gordon Research Seminar: The Future of Peptides in Chemistry and Biology, 2012”.

פירסומים

Publications

Peer-Reviewed Publications

 

2017

  • Cunningham AD*, Qvit N*,# Mochly-Rosen D# (2017). Peptides and Peptidomimetics as Regulators of Protein-Protein Interactions. Current Opinion in Structural Biology, 44, 59-66. *Equal contribution, #Corresponding authors. Invited article
     
  • Qvit N#, Rubin S, Urban TJ, Mochly-Rosen D, Gross RE (2017). Peptidomimetic Therapeutics: Scientific Approaches and Opportunities. Drug Discovery Today, 22, (2), 454-462. #Corresponding author. Invited article

 

2016

  • Qvit N#, Kornfeld OS, Mochly-Rosen D# (2016). Engineered Substrate‐Specific Delta PKC Isoform Antagonists to Enhance Cardiac Therapeutics. Angewandte Chemie International Edition, 12, 55(50), 15672 -15679. #Corresponding authors.
  • Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW (2016). Correcting Mitochondrial Fusion Defects by Manipulating Mitofusin Conformation. Nature, 1, 540(7631), 74-79.
  • Qvit N, Disatnik MH, Jie S, Mochly-Rosen D (2016). Selective Phosphorylation Inhibitor of δPKC-PDK Protein-Protein Interactions; Application for Myocardial Injury in Vivo. Journal of the American Chemical Society, 22, 138(24), 7626-7635.
  • Hurt MC, Lu Y, Stary C, Piplani H, Small AB, Urban JT, Qvit N, Gross JG, Mochly-Rosen D, Gross RE (2016). Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial 2 Membrane Potential and Myocardial Reperfusion Injury. Journal of the American Heart Association, 26, 5(9), e003774, 1-13.
  • Qvit N#, Joshi AU, Cunningham AD, Ferreira CBJ, Mochly-Rosen D# (2016). GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death. Journal of Biological Chemistry, 24, 291(26), 13608-13621. #Corresponding authors.
  • Qvit N#, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang AL, Baron LA, Teh-Poot C, Martínez-Vega P, Remirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, Gozzo FC, Torrecilhas AC, Alves MJM, Jardim A, Momar N, Dumonteil E, Mochly-Rosen D (2016). Scaffold Proteins LACK and TRACK as Potential Drug Targets in Kinetoplastid Parasites: Development of Inhibitors. International Journal for Parasitology: Drugs and Drug Resistance, 6, 74-84. #Corresponding author.
  • Qvit N#, Kornfeld OS (2016). Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation. Journal of Visualized Experiments, 107, e53589, 1-14. #Corresponding author. Invited article
  • Cunningham AD*, Qvit N*,# (2016). Specific Kinase Inhibition Using Peptides to Target Kinase-Substrate Docking. Chimica Oggi/Chemistry Today, 34(5), 16, 22-25. *Equal contribution, #Corresponding author. Invited article
  • Rubin S*, Qvit N*,# (2016). Cyclic Peptides for Protein-Protein Interaction Targets: Applications to Human Disease. Critical Reviews in Eukaryotic Gene Expression, 26(3), 199-221. *Equal contribution, #Corresponding author. Invited article
  • Featured on the front cover

 

2015

  • Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D (2015). Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases. Circulation Research, 116(11), 1783-1799. Invited article

 

2014

  • Qvit N# (2014). Microwave Assisted Synthesis of Cyclic Phosphopeptides on Solid Support. Chemical Biology and Drug Design, 85(3), 300-305. #Corresponding author.
  • Qvit N#, Crapster JA (2014). Peptides that Target Protein-Protein Interactions as an Anti-Parasite Strategy. Chimica Oggi/Chemistry Today, 32(6), 62-66. #Corresponding author. Invited article
  • Qvit N, Mochly-Rosen D (2014). The Many Hats of Delta Protein Kinase C; One Enzyme with Many Functions. Biochemical Society Transactions, 42(6), 1529-1533. Invited article
  • Qvit N, Disatnik MH, Mochly-Rosen D (2014). Engineering a Delta Protein Kinase C Inhibitor that Selectively Inhibits Interaction and Phosphorylation of One Substrate of the Multi-Substrate Kinase. The FASEB Journal, 28, 1.

 

2013

  • Qi X*, Qvit N*, Su YC, Mochly-Rosen D (2013). A Novel Drp1 Inhibitor Diminishes Aberrant Mitochondrial Fission and Neurotoxicity. Journal of Cell Science, 126(Pt 3), 789-802. *Equal contribution.
  • This article was mentioned as a future direction in a review about mitochondrial dynamics. Archer, S. L. (2013).  Mitochondrial Dynamics-Mitochondrial Fission and Fusion in Human Diseases. New England Journal of Medicine, 369, 2236.

 

2012

  • Qvit N, Disatnik MH, Mochly-Rosen D (2012). Novel Selective Peptide Regulator of Protein Kinase C Based on Rational Approach Design. Biosensors and Bioelectronics, 2, 142.

 

2011

  • Qvit N# (2011). Development and Therapeutics Applications of Oligonucleotides and Peptides. Chimica Oggi/Chemistry Today, 29(2), 16, 4-7. #Corresponding author. Invited article

 

2010

  • Qvit N, Mochly-Rosen D (2010). Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. Drug Discovery Today: Disease Mechanisms, 7(2), e87-e93. Invited article
  • Mochly-Rosen D, Qvit N (2010). Peptide Inhibitors of Protein-Protein Interactions: From Rational Design to the Clinic. Chimica Oggi/Chemistry Today, 28(1), 14-16. Invited article

 

2009

  • Qvit N, Hatzubai A, Shalev ED, Ben-Neriah Y, Gilon C (2009). Design and Synthesis of Backbone Cyclic Phosphorylated Peptides: The I Kappa B Model. Biopolymers, 91(2), 157-168.
  • Churchill E*, Qvit N*, Mochly-Rosen D (2009). Rationally Designed Peptide Regulators of Protein Kinase C. Trends in Endocrinology and Metabolism, 20(1), 25-33. *Equal contribution. Invited article
  • Qvit N, Disatnik MH, Mochly-Rosen D (2009). Peptide Regulators of Protein-Protein Interactions with Selectivity for Specific Sub-Cellular Compartments. Biopolymers, 92, 322.
  • Qvit N, Hatzubai A, Shalev ED, Ben-Neriah Y, Gilon C (2009). Design and Synthesis of Backbone Cyclic Phosphopeptides: The IκB Model. Advances in Experimental Medicine and Biology, 611, 139-140.

 

2008

  • Qvit N#, Monderer-Rothkoff G, Ido A, Shalev ED, Amster-Choder O, Gilon C# (2008). Development of Bifunctional Photoactivatable Benzophenone Probes and their Application to Glycoside Substrates. Biopolymers, 90(4), 526-536. #Corresponding authors.
  • This article was chosen as one of the top 20 articles in the National Library of Medicine's since its publication (MEDLINE database, BioMedLib, http://bmlsearch.com/).
  • Qvit N, Reuveni H, Gazal S, Zundelevich A, Blum G, Niv YM, Feldstein A, Meushar S, Shalev ED, Friedler A, Gilon C (2008). Synthesis of Novel Macrocyclic Library: Discovery of an IGF-1R Inhibitor. Journal of Combinatorial Chemistry, 10(2), 256-266.
  • Nuti F, Qvit N, Rizzolo F, Hurevich M, Carotenuto A, Peroni E, Chelli M, Rovero P, Gilon C, Papini AM  (2008). Microwave-Assisted Solid Phase Synthesis of Backbone Cyclic Glycopeptide Libraries. Journal of Peptide Science, 14, 131.

 

2007

  • Qvit N, Barda Y, Shalev ED, Gilon C (2007). A Laboratory Preparation of Aspartame Analogs Using Simultaneous Multiple Parallel Synthesis Methodology. Journal of Chemical Education, 84(12), 1988-1991.

2006

  • Qvit N, Gilon C, Amster-Choder O, Monderer-Rothkoff G (2006). Using Novel Benzophenon-Glucosides to Study Microbial Sugar Recognition and Translocation by Photo-Affinity Labeling. Journal of Peptide Science, 12, 84.

 

2004

  • Qvit N, Reuveni H, Gazal S, Peretzman-Shemer A, Blum G, Niv YM, Feldstein A, Meushar S, Gilon C (2004). Novel Macrocyclic Libraries with Spatial Diversity (SIBs): Application for the Discovery of IGF-1R Inhibitor. Journal of Peptide Science, 10, 95.

 

 

 

קורסים

Medicinal Chemistry of Drug Discovery

כימיה רפואית של גילוי תרופות

 

Peptide therapeutics

פפטידים ופיתוח תרופות

 

Drug discovery and developments in developing countries

גילוי ופיתוח תרופות במדינות מתפתחות